PMID- 29489865
OWN - NLM
STAT- MEDLINE
DCOM- 20180528
LR  - 20210925
IS  - 1932-6203 (Electronic)
IS  - 1932-6203 (Linking)
VI  - 13
IP  - 2
DP  - 2018
TI  - Evaluation of the INTERGROWTH-21st Neurodevelopment Assessment (INTER-NDA) in 2 
      year-old children.
PG  - e0193406
LID - 10.1371/journal.pone.0193406 [doi]
LID - e0193406
AB  - BACKGROUND: The INTER-NDA is a novel assessment of early child development 
      measuring cognition, language, motor skills, behaviour, attention, and 
      socio-emotional reactivity in 2 year olds in 15 minutes. Here, we present the 
      results of an evaluation of the INTER-NDA against the Bayley Scales of Infant 
      Development III edition (BSID-III), its sensitivity and specificity and its 
      psychometric properties. METHODS: Eighty-one infants from Oxford, UK, aged 
      23.1-28.3 months, were evaluated using the INTER-NDA and the BSID-III. The 
      agreement between the INTER-NDA and the BSID-III was assessed using interclass 
      correlations (for absolute agreement), Bland-Altman analyses (for bias and limits 
      of agreement), and sensitivity and specificity analyses (for accuracy). The 
      internal consistency of the INTER-NDA and uni-dimensionality of its subscales 
      were also determined. RESULTS: The interclass correlation coefficients between 
      the BSID-III and the INTER-NDA cognitive, motor and behaviour scores ranged 
      between 0.745 and 0.883 (p<0.001). The Bland-Altman analysis showed little to no 
      bias in the aforementioned subscales. The sensitivity and specificity of 
      INTER-NDA cognitive scores </=1 SD below the mean are 66.7% and 98.6% respectively, 
      with moderate agreement between INTER-NDA and BSID-III classifications (kappa = 0.72, 
      p<0.001). The sensitivity and specificity of INTER-NDA scores <2 SD below the 
      mean, in predicting low BSID-III scores (<70), are 100% each for cognition, and 
      25% and 100% respectively for language. More than 97% of children who scored in 
      the normal range of the INTER-NDA (<1SD below mean) also scored in the normal 
      range in the BSID-III (>/=85). The INTER-NDA demonstrates satisfactory internal 
      consistency and its subscales demonstrate good unidimensionality. CONCLUSION: The 
      INTER-NDA shows good agreement with the BSID-III, and demonstrates satisfactory 
      psychometric properties, for the assessment of ECD at 22-28 months.
FAU - Murray, Elizabeth
AU  - Murray E
AD  - Department of Psychiatry, Warneford Hospital, University of Oxford, Oxford, 
      United Kingdom.
FAU - Fernandes, Michelle
AU  - Fernandes M
AUID- ORCID: 0000-0002-0051-3389
AD  - Nuffield Department of Obstetrics & Gynaecology, John Radcliffe Hospital, 
      University of Oxford, Oxford, United Kingdom.
AD  - Oxford Maternal & Perinatal Health Institute, Green Templeton College, University 
      of Oxford, Oxford, United Kingdom.
AD  - Department of Paediatrics, Southampton General Hospital, University of 
      Southampton, Southampton, United Kingdom.
FAU - Newton, Charles R J
AU  - Newton CRJ
AD  - Department of Psychiatry, Warneford Hospital, University of Oxford, Oxford, 
      United Kingdom.
FAU - Abubakar, Amina
AU  - Abubakar A
AD  - Department of Psychiatry, Warneford Hospital, University of Oxford, Oxford, 
      United Kingdom.
AD  - Department of Psychology, Lancaster University, Lancaster, United Kingdom.
FAU - Kennedy, Stephen H
AU  - Kennedy SH
AD  - Nuffield Department of Obstetrics & Gynaecology, John Radcliffe Hospital, 
      University of Oxford, Oxford, United Kingdom.
AD  - Oxford Maternal & Perinatal Health Institute, Green Templeton College, University 
      of Oxford, Oxford, United Kingdom.
FAU - Villar, Jose
AU  - Villar J
AD  - Nuffield Department of Obstetrics & Gynaecology, John Radcliffe Hospital, 
      University of Oxford, Oxford, United Kingdom.
AD  - Oxford Maternal & Perinatal Health Institute, Green Templeton College, University 
      of Oxford, Oxford, United Kingdom.
FAU - Stein, Alan
AU  - Stein A
AD  - Department of Psychiatry, Warneford Hospital, University of Oxford, Oxford, 
      United Kingdom.
LA  - eng
GR  - WT_/Wellcome Trust/United Kingdom
GR  - 090139/WT_/Wellcome Trust/United Kingdom
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20180228
PL  - United States
TA  - PLoS One
JT  - PloS one
JID - 101285081
SB  - IM
MH  - Behavior
MH  - *Child Development
MH  - Child, Preschool
MH  - Cognition
MH  - Female
MH  - Humans
MH  - Infant
MH  - Language
MH  - Male
MH  - Reproducibility of Results
PMC - PMC5831101
COIS- Competing Interests: The authors have declared that no competing interests exist.
EDAT- 2018/03/01 06:00
MHDA- 2018/05/29 06:00
PMCR- 2018/02/28
CRDT- 2018/03/01 06:00
PHST- 2017/07/09 00:00 [received]
PHST- 2018/02/09 00:00 [accepted]
PHST- 2018/03/01 06:00 [entrez]
PHST- 2018/03/01 06:00 [pubmed]
PHST- 2018/05/29 06:00 [medline]
PHST- 2018/02/28 00:00 [pmc-release]
AID - PONE-D-17-25814 [pii]
AID - 10.1371/journal.pone.0193406 [doi]
PST - epublish
SO  - PLoS One. 2018 Feb 28;13(2):e0193406. doi: 10.1371/journal.pone.0193406. 
      eCollection 2018.