PMID- 29491100
OWN - NLM
STAT- MEDLINE
DCOM- 20180312
LR  - 20181202
IS  - 1791-7530 (Electronic)
IS  - 0250-7005 (Linking)
VI  - 38
IP  - 3
DP  - 2018 Mar
TI  - A Retrospective Multicenter Study of Carbon Ion Radiotherapy for Locally Advanced 
      Olfactory Neuroblastomas.
PG  - 1665-1670
AB  - The purpose was to evaluate efficacy and safety of carbon ion radiotherapy (C-ion 
      RT) in patients with locally advanced olfactory neuroblastomas (ONBs). This study 
      was a sub-analysis of the Japan Carbon-Ion Radiation Oncology Study Group Study 
      (1402 HN, UMIN000024473). Clinical data of T4 ONBs treated with C-ion RT at four 
      Institutions between November 2003 and December 2014 were retrospectively 
      reviewed. Twenty-one patients underwent C-ion RT. Seven patients had T4a and 14 
      had T4b tumours without cervical node metastases. The median follow-up period was 
      39 (range=5-111) months. The 3-year overall survival and local control rates were 
      88.4% and 83.0%, respectively. Grade 4 late toxicity was observed in three 
      patients, including ipsilateral optic nerve disorder (n=2) and ipsilateral 
      retinopathy (n=1). C-Ion RT is effective and can be a curative modality for T4 
      ONBs. Prospective multicenter studies are warranted to confirm these findings.
CI  - Copyright(c) 2018, International Institute of Anticancer Research (Dr. George J. 
      Delinasios), All rights reserved.
FAU - Suefuji, Hiroaki
AU  - Suefuji H
AD  - Ion Beam Therapy Center, SAGA-HIMAT Foundation, Tosu, Japan sufg@saga-himat.jp.
FAU - Koto, Masashi
AU  - Koto M
AD  - Hospital of the National Institute of Radiological Science, National Institutes 
      for Quantum and Radiological Sciences and Technology, Chiba, Japan.
FAU - Demizu, Yusuke
AU  - Demizu Y
AD  - Department of Radiology, Hyogo Ion Beam Medical Center, Tatsuno, Japan.
FAU - Saitoh, Jun-Ichi
AU  - Saitoh JI
AD  - Gunma University Heavy Ion Medical Center, Maebashi, Japan.
FAU - Shioyama, Yoshiyuki
AU  - Shioyama Y
AD  - Ion Beam Therapy Center, SAGA-HIMAT Foundation, Tosu, Japan.
FAU - Tsuji, Hiroshi
AU  - Tsuji H
AD  - Hospital of the National Institute of Radiological Science, National Institutes 
      for Quantum and Radiological Sciences and Technology, Chiba, Japan.
FAU - Okimoto, Tomoaki
AU  - Okimoto T
AD  - Department of Radiology, Hyogo Ion Beam Medical Center, Tatsuno, Japan.
FAU - Ohno, Tatsuya
AU  - Ohno T
AD  - Gunma University Heavy Ion Medical Center, Maebashi, Japan.
FAU - Nemoto, Kenji
AU  - Nemoto K
AD  - Department of Radiation Oncology, Yamagata University Faculty of Medicine, 
      Yamagata, Japan.
FAU - Nakano, Takashi
AU  - Nakano T
AD  - Gunma University Heavy Ion Medical Center, Maebashi, Japan.
FAU - Kamada, Tadashi
AU  - Kamada T
AD  - Hospital of the National Institute of Radiological Science, National Institutes 
      for Quantum and Radiological Sciences and Technology, Chiba, Japan.
LA  - eng
PT  - Journal Article
PT  - Multicenter Study
PL  - Greece
TA  - Anticancer Res
JT  - Anticancer research
JID - 8102988
SB  - IM
MH  - Adult
MH  - Aged
MH  - Disease-Free Survival
MH  - Dose Fractionation, Radiation
MH  - Esthesioneuroblastoma, Olfactory/*radiotherapy
MH  - Female
MH  - Heavy Ion Radiotherapy/adverse effects/*methods
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Mucositis/etiology
MH  - Nasal Cavity/pathology/*radiation effects
MH  - Nose Neoplasms/*radiotherapy
MH  - Optic Nerve Diseases/etiology
MH  - Retrospective Studies
MH  - Treatment Outcome
OTO - NOTNLM
OT  - Olfactory neuroblastoma
OT  - cancer of the head and neck
OT  - carbon ion radiotherapy
OT  - multicenter study
OT  - radiotherapy
EDAT- 2018/03/02 06:00
MHDA- 2018/03/13 06:00
CRDT- 2018/03/02 06:00
PHST- 2017/11/27 00:00 [received]
PHST- 2017/12/14 00:00 [revised]
PHST- 2017/12/18 00:00 [accepted]
PHST- 2018/03/02 06:00 [entrez]
PHST- 2018/03/02 06:00 [pubmed]
PHST- 2018/03/13 06:00 [medline]
AID - 38/3/1665 [pii]
AID - 10.21873/anticanres.12399 [doi]
PST - ppublish
SO  - Anticancer Res. 2018 Mar;38(3):1665-1670. doi: 10.21873/anticanres.12399.