PMID- 29491673
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220316
IS  - 0974-8520 (Print)
IS  - 0976-9382 (Electronic)
IS  - 0974-8520 (Linking)
VI  - 37
IP  - 3-4
DP  - 2016 Jul-Dec
TI  - Clinical validation of efficacy and safety of herbal cough formulation "Honitus 
      syrup" for symptomatic relief of acute non-productive cough and throat 
      irritation.
PG  - 206-214
LID - 10.4103/ayu.AYU_156_15 [doi]
AB  - BACKGROUND: Acute cough represents the most common illness evaluated in the 
      outpatient settings. Available remedies for its management are generally 
      allopathic combinations of antihistamines and decongestants that achieve 
      antitussive activity, but often with unpleasant side effects prompting the need 
      to explore safer and effective options. Honitus is an Ayurvedic proprietary 
      herbal cough syrup with benefits of honey, intended to provide relief in acute 
      nonproductive cough and throat irritation without causing drowsiness. This study 
      investigated the safety and efficacy of Honitus in reducing acute nonproductive 
      cough and throat irritation in comparison to a standard marketed allopathic cough 
      syrup intended for use in similar conditions. MATERIALS AND METHODS: This was a 
      randomized double-blind study conducted in 105 individuals who received orally 2 
      tsp (10 ml) of either Honitus or marketed cough syrup (MCS) four times a day for 
      3 days. Response to treatment was evaluated from baseline to the end of treatment 
      period on the basis of changes in day and night frequencies of cough, throat 
      irritation and development of adverse events (AEs). RESULTS: Honitus was found 
      safe and effective in reducing symptoms of acute nonproductive cough, throat 
      irritation, and comparable to MCS in reducing day and night frequencies of cough, 
      the time to relief from cough and throat irritation and the Physician's Global 
      Assessment of cough. Honitus showed comparably better results than MCS on throat 
      irritation, the duration of relief from cough and throat irritation without 
      causing drowsiness. No AEs related to study or study products were reported. 
      CONCLUSION: Honitus Syrup is safe and effective in reducing the symptoms of acute 
      nonproductive cough and throat irritation without causing drowsiness.
FAU - Gupta, Arun
AU  - Gupta A
AD  - Medical Affairs and Clinical Research Division, Principal Scientist - Healthcare 
      Research, Healthcare Research, Dabur Research and Development Centre, Dabur India 
      Limited, Sahibabad (Ghaziabad), UP, India.
FAU - Gaikwad, Vaijayanti
AU  - Gaikwad V
AD  - Medical Affairs and Clinical Research Division, Clinician and Independent 
      Researcher, Ghatkopar, Mumbai, India.
FAU - Kumar, Satyendra
AU  - Kumar S
AD  - Medical Affairs and Clinical Research Division, Principal Scientist - Healthcare 
      Research, Healthcare Research, Dabur Research and Development Centre, Dabur India 
      Limited, Sahibabad (Ghaziabad), UP, India.
FAU - Srivastava, Ruchi
AU  - Srivastava R
AD  - Medical Affairs and Clinical Research Division, Principal Scientist - Healthcare 
      Research, Healthcare Research, Dabur Research and Development Centre, Dabur India 
      Limited, Sahibabad (Ghaziabad), UP, India.
FAU - Sastry, Jln
AU  - Sastry J
AD  - Medical Affairs and Clinical Research Division, Principal Scientist - Healthcare 
      Research, Healthcare Research, Dabur Research and Development Centre, Dabur India 
      Limited, Sahibabad (Ghaziabad), UP, India.
LA  - eng
PT  - Journal Article
PL  - India
TA  - Ayu
JT  - Ayu
JID - 7605807
PMC - PMC5822975
OTO - NOTNLM
OT  - Acute nonproductive cough
OT  - Honitus
OT  - herbal
OT  - throat irritation
COIS- Some of the authors of the research article are currently employed with the 
      sponsor, Dabur India Limited, which is also marketing this product.
EDAT- 2016/07/01 00:00
MHDA- 2016/07/01 00:01
PMCR- 2016/07/01
CRDT- 2018/03/02 06:00
PHST- 2018/03/02 06:00 [entrez]
PHST- 2016/07/01 00:00 [pubmed]
PHST- 2016/07/01 00:01 [medline]
PHST- 2016/07/01 00:00 [pmc-release]
AID - AYU-37-206 [pii]
AID - 10.4103/ayu.AYU_156_15 [doi]
PST - ppublish
SO  - Ayu. 2016 Jul-Dec;37(3-4):206-214. doi: 10.4103/ayu.AYU_156_15.