PMID- 29491777
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20200930
IS  - 1568-5551 (Electronic)
IS  - 1385-772X (Print)
IS  - 1385-772X (Linking)
VI  - 20
IP  - 1
DP  - 2017
TI  - One-step grafting of temperature-and pH-sensitive 
      (N-vinylcaprolactam-co-4-vinylpyridine) onto silicone rubber for drug delivery.
PG  - 33-41
LID - 10.1080/15685551.2016.1231033 [doi]
AB  - A one-step method was implemented to graft N-vinylcaprolactam (NVCL) and 
      4-vinylpyridine (4VP) onto silicone rubber (SR) films using gamma radiation in 
      order to endow the silicone surface with temperature- and pH-responsiveness, and 
      give it the ability to host and release diclofenac in a controlled manner and 
      thus prevent bacterial adhesion. The effects of radiation conditions (e.g., dose 
      and monomers concentration) on the grafting percentage were evaluated, and the 
      modified films were characterized by means of FTIR-ATR, Raman spectroscopy, 
      calorimetry techniques (DSC and TGA) and contact angle measurements. The films 
      responsiveness to stimuli was evaluated by recording the swelling degree of 
      pristine and modified SR in buffer solutions (critical pH point) and as a 
      function of changes in temperature (Upper Critical Solution Temperature, UCST). 
      The graft copolymers of SR-g-(NVCL-co-4VP) showed good cytocompatibility against 
      fibroblast cells for prolonged times, could host diclofenac and release it in a 
      sustained manner for up to 24 h, and exhibited bacteriostatic activity when 
      challenged against Escherichia coli.
FAU - Pino-Ramos, Victor H
AU  - Pino-Ramos VH
AD  - Departamento de Quimica de Radiaciones y Radioquimica, Instituto de Ciencias 
      Nucleares, Universidad Nacional Autonoma de Mexico, Circuito Exterior, Ciudad 
      Universitaria, MexicoDF 04510, Mexico.
FAU - Alvarez-Lorenzo, Carmen
AU  - Alvarez-Lorenzo C
AUID- ORCID: 0000-0002-8546-7085
AD  - Facultad de Farmacia, Departamento de Farmacia y Tecnologia Farmaceutica, R+D 
      Pharma Group (GI-1645), Universidade de Santiago de Compostela, Santiago de 
      Compostela, Spain.
FAU - Concheiro, Angel
AU  - Concheiro A
AUID- ORCID: 0000-0003-0507-049X
AD  - Facultad de Farmacia, Departamento de Farmacia y Tecnologia Farmaceutica, R+D 
      Pharma Group (GI-1645), Universidade de Santiago de Compostela, Santiago de 
      Compostela, Spain.
FAU - Bucio, Emilio
AU  - Bucio E
AUID- ORCID: 0000-0003-4853-125X
AD  - Departamento de Quimica de Radiaciones y Radioquimica, Instituto de Ciencias 
      Nucleares, Universidad Nacional Autonoma de Mexico, Circuito Exterior, Ciudad 
      Universitaria, MexicoDF 04510, Mexico.
LA  - eng
PT  - Journal Article
DEP - 20160920
PL  - England
TA  - Des Monomers Polym
JT  - Designed monomers and polymers
JID - 101239706
PMC - PMC5812122
OTO - NOTNLM
OT  - Dually responsive
OT  - bacteria adhesion
OT  - cytocompatibility
OT  - diclofenac sodium
OT  - drug-eluting device
OT  - silicone rubber
EDAT- 2016/09/20 00:00
MHDA- 2016/09/20 00:01
PMCR- 2016/09/20
CRDT- 2018/03/02 06:00
PHST- 2016/04/28 00:00 [received]
PHST- 2016/07/30 00:00 [accepted]
PHST- 2018/03/02 06:00 [entrez]
PHST- 2016/09/20 00:00 [pubmed]
PHST- 2016/09/20 00:01 [medline]
PHST- 2016/09/20 00:00 [pmc-release]
AID - 1231033 [pii]
AID - 10.1080/15685551.2016.1231033 [doi]
PST - epublish
SO  - Des Monomers Polym. 2016 Sep 20;20(1):33-41. doi: 10.1080/15685551.2016.1231033. 
      eCollection 2017.