PMID- 29492204
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20191120
IS  - 1949-2553 (Electronic)
IS  - 1949-2553 (Linking)
VI  - 9
IP  - 9
DP  - 2018 Feb 2
TI  - Stromal versus tumoral inflammation differentially contribute to metastasis and 
      poor survival in laryngeal squamous cell carcinoma.
PG  - 8415-8426
LID - 10.18632/oncotarget.23865 [doi]
AB  - In solid tumors the biology and clinical course are strongly influenced by the 
      interaction of tumor cells and infiltrating stromal host cells. The aim of this 
      study was to assess the relative importance of stromal vs. tumoral inflammation 
      for metastasis and survival in patients with laryngeal squamous cell carcinoma 
      (LSCC). In 110 patients with tissues from histologically proven LSCC the 
      expression of CD45, CD11b, CD3, MMP-9 and COX-2 was semiquantitatively analyzed 
      in stromal regions and tumor nests. CD45, CD11b, CD3 and MMP-9 positive cells 
      were more abundant in stroma whereas COX-2 was predominantly expressed in 
      epithelial tumor nests. High expression of stromal CD45 and CD11b on immune cells 
      in tumor regions correlated with COX-2 expression on tumor cells. High levels of 
      CD45 in stroma as well as CD11b and COX-2 in tumor nests were associated with 
      increased metastasis. In contrast, high frequencies of CD3 cells in the tumor 
      core area were associated with reduced metastasis. Overall survival was reduced 
      in patients with high stromal CD45, high tumoral CD11b and high tumoral COX-2 
      expression. This is the first study which separately analyzes peritumoral stroma 
      and tumor core area in laryngeal squamous cell carcinoma in terms of CD45, CD11b, 
      CD3, MMP-9 and COX-2 expression. Our results indicate that stroma and tumor 
      islands need to be considered as two separate compartments in the inflammatory 
      tumor microenvironment. Inflammatory stromal leukocytes, abundant myeloid cells 
      in tumor regions and high expression of COX-2 on tumor cells are linked to 
      metastatic disease and poor overall survival.
FAU - Hoing, Benedikt
AU  - Hoing B
AD  - Department of Otorhinolaryngology, Head and Neck Surgery, University Hospital 
      Essen, Essen, Germany.
FAU - Kanaan, Oliver
AU  - Kanaan O
AD  - Department of Otorhinolaryngology, Head and Neck Surgery, University Hospital 
      Essen, Essen, Germany.
FAU - Altenhoff, Petra
AU  - Altenhoff P
AD  - Department of Otorhinolaryngology, Head and Neck Surgery, University Hospital 
      Essen, Essen, Germany.
FAU - Petri, Robert
AU  - Petri R
AD  - Department of Otorhinolaryngology, Head and Neck Surgery, University Hospital 
      Essen, Essen, Germany.
FAU - Thangavelu, Kruthika
AU  - Thangavelu K
AD  - Department of Otorhinolaryngology, Head and Neck Surgery, University Hospital 
      Essen, Essen, Germany.
FAU - Schluter, Anke
AU  - Schluter A
AD  - Department of Otorhinolaryngology, Head and Neck Surgery, University Hospital 
      Essen, Essen, Germany.
FAU - Lang, Stephan
AU  - Lang S
AD  - Department of Otorhinolaryngology, Head and Neck Surgery, University Hospital 
      Essen, Essen, Germany.
FAU - Bankfalvi, Agnes
AU  - Bankfalvi A
AD  - Institute of Pathology, University Hospital Essen, Essen, Germany.
FAU - Brandau, Sven
AU  - Brandau S
AD  - Department of Otorhinolaryngology, Head and Neck Surgery, University Hospital 
      Essen, Essen, Germany.
LA  - eng
PT  - Journal Article
DEP - 20180103
PL  - United States
TA  - Oncotarget
JT  - Oncotarget
JID - 101532965
PMC - PMC5823564
OTO - NOTNLM
OT  - cancer-related inflammation
OT  - head and neck cancer
OT  - leukocytes
OT  - nodal metastasis
OT  - tumor stroma
COIS- CONFLICTS OF INTEREST None.
EDAT- 2018/03/02 06:00
MHDA- 2018/03/02 06:01
PMCR- 2018/02/02
CRDT- 2018/03/02 06:00
PHST- 2017/05/30 00:00 [received]
PHST- 2017/11/16 00:00 [accepted]
PHST- 2018/03/02 06:00 [entrez]
PHST- 2018/03/02 06:00 [pubmed]
PHST- 2018/03/02 06:01 [medline]
PHST- 2018/02/02 00:00 [pmc-release]
AID - 23865 [pii]
AID - 10.18632/oncotarget.23865 [doi]
PST - epublish
SO  - Oncotarget. 2018 Jan 3;9(9):8415-8426. doi: 10.18632/oncotarget.23865. 
      eCollection 2018 Feb 2.