PMID- 29492224
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20230919
IS  - 1949-2553 (Electronic)
IS  - 1949-2553 (Linking)
VI  - 9
IP  - 9
DP  - 2018 Feb 2
TI  - Remote ischemic conditioning improves myocardial parameters and clinical outcomes 
      during primary percutaneous coronary intervention: a meta-analysis of randomized 
      controlled trials.
PG  - 8653-8664
LID - 10.18632/oncotarget.23818 [doi]
AB  - We conducted a systematic review and meta-analysis to evaluate the effects of 
      remote ischemic conditioning on myocardial parameters and clinical outcomes in ST 
      segment elevation acute myocardial infarction (STEMI) patients undergoing primary 
      percutaneous coronary intervention. Ten eligible randomized controlled trials 
      with 1006 STEMI patients were identified. Compared with controls, remote ischemic 
      conditioning reduced the myocardial enzyme levels (standardized mean difference 
      =-0.86; 95% CI: -1.44 to -0.28; P = 0.004; I(2) = 94.5%), and increased the 
      incidence of complete ST-segment resolution [odds ratio (OR) = 1.74; 95% CI: 1.09 
      to 2.77; P = 0.02; I(2) = 47.9%]. Remote ischemic conditioning patients had a 
      lower risk of all-cause mortality (OR = 0.27; 95% CI: 0.12 to 0.62; P = 0.002; 
      I(2) = 0.0%) and lower major adverse cardiovascular and cerebrovascular events 
      rate (OR=0.45; 95% CI: 0.27 to 0.75; P = 0.002; I(2) = 0.0%). Meta-analysis 
      suggested that remote ischemic conditioning conferred cardioprotection by 
      reducing myocardial enzymes and increasing the incidence of complete ST-segment 
      resolution in patients after STEMI. As a result, clinical outcomes were improved 
      in terms of mortality and incidence of major adverse cardiovascular and 
      cerebrovascular events.
FAU - Liu, Hai
AU  - Liu H
AD  - Third Department of Cardiac Surgery, First Affiliated Hospital of Zhengzhou 
      University, Zhengzhou 450052, Henan, China.
FAU - Fu, Li
AU  - Fu L
AD  - Institute of Clinical Medicine, Department of Endocrinology, The Central Hospital 
      of Loudi Affiliated to the University of South China, Loudi 417000, China.
FAU - Sun, Xiangke
AU  - Sun X
AD  - Department of Cardiology, The Central Hospital of Loudi Affiliated to the 
      University of South China, Loudi 417000, China.
FAU - Peng, Wei
AU  - Peng W
AD  - Department of Cardiology, The Central Hospital of Loudi Affiliated to the 
      University of South China, Loudi 417000, China.
FAU - Chen, Zhiwei
AU  - Chen Z
AD  - Department of Cardiology, The Central Hospital of Loudi Affiliated to the 
      University of South China, Loudi 417000, China.
FAU - Li, Yiliang
AU  - Li Y
AD  - Department of Neurology, The Third Xiangya Hospital, Central South University, 
      Changsha, Hunan 410013, China.
AD  - Postdoctoral Research Workstation of Neurology, Clinical Medicine, The Third 
      Xiangya Hospital, Central South University, Changsha 410013, China.
LA  - eng
PT  - Journal Article
DEP - 20171222
PL  - United States
TA  - Oncotarget
JT  - Oncotarget
JID - 101532965
PMC - PMC5823569
OTO - NOTNLM
OT  - cardioprotection
OT  - clinical outcome
OT  - primary percutaneous coronary intervention
OT  - remote ischemic conditioning
COIS- CONFLICTS OF INTEREST None.
EDAT- 2018/03/02 06:00
MHDA- 2018/03/02 06:01
PMCR- 2018/02/02
CRDT- 2018/03/02 06:00
PHST- 2017/07/10 00:00 [received]
PHST- 2017/12/04 00:00 [accepted]
PHST- 2018/03/02 06:00 [entrez]
PHST- 2018/03/02 06:00 [pubmed]
PHST- 2018/03/02 06:01 [medline]
PHST- 2018/02/02 00:00 [pmc-release]
AID - 23818 [pii]
AID - 10.18632/oncotarget.23818 [doi]
PST - epublish
SO  - Oncotarget. 2017 Dec 22;9(9):8653-8664. doi: 10.18632/oncotarget.23818. 
      eCollection 2018 Feb 2.