PMID- 29492303
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20240315
IS  - 2058-5888 (Print)
IS  - 2058-5888 (Electronic)
IS  - 2058-5888 (Linking)
VI  - 3
IP  - 1
DP  - 2017 Jan
TI  - Association between DNA methylation profiles in leukocytes and serum levels of 
      persistent organic pollutants in Dutch men.
PG  - dvx001
LID - 10.1093/eep/dvx001 [doi]
LID - dvx001
AB  - Consumption of polluted fish may lead to high levels of persistent organic 
      pollutants (POPs) in humans, potentially causing adverse health effects. Altered 
      DNA methylation has been suggested as a possible contributor to a variety of 
      adverse health effects. The aim of this study was to evaluate the relationship 
      between serum POP levels (dioxins, polychlorobiphenyls, and perfluoroctane 
      sulphonate) and DNA methylation. We recruited a total of 80 Dutch men who 
      regularly consumed eel from either low- or high-polluted areas, and subsequently 
      had normal or elevated POP levels. Clinical parameters related to e.g. hormone 
      levels and liver enzymes were measured as biomarkers for adverse health effects. 
      The Infinium 450K BeadChip was used to assess DNA methylation in a representative 
      subset of 34 men. We identified multiple genes with differentially methylated 
      regions (DMRs; false discovery rate <0.05) related to POP levels. Several of 
      these genes are involved in carcinogenesis (e.g. BRCA1, MAGEE2, HOXA5), the 
      immune system (e.g. RNF39, HLA-DQB1), retinol homeostasis (DHRS4L2), or in 
      metabolism (CYP1A1). The DMRs in these genes show mean methylation differences up 
      to 7.4% when comparing low- and high-exposed men, with a mean difference up to 
      14.4% for single positions within a DMR. Clinical parameters were not 
      significantly associated with serum POP levels. This is the first explorative 
      study investigating extensive DNA methylation in relation to serum POP levels 
      among men. We observed that elevated POP levels are associated with aberrant DNA 
      methylation profiles in adult men who consumed high-polluted eel. These 
      preliminary findings warrant further confirmation in other populations.
FAU - van den Dungen, Myrthe W
AU  - van den Dungen MW
AD  - Division of Human Nutrition, Stippeneng 4, 6708 WE, Wageningen, Wageningen 
      University, The Netherlands.
AD  - Marine Animal Ecology Group, De Elst 1, 6708 WD, Wageningen, Wageningen 
      University, The Netherlands.
FAU - Murk, Albertinka J
AU  - Murk AJ
AD  - Marine Animal Ecology Group, De Elst 1, 6708 WD, Wageningen, Wageningen 
      University, The Netherlands.
FAU - Kampman, Ellen
AU  - Kampman E
AD  - Division of Human Nutrition, Stippeneng 4, 6708 WE, Wageningen, Wageningen 
      University, The Netherlands.
FAU - Steegenga, Wilma T
AU  - Steegenga WT
AD  - Division of Human Nutrition, Stippeneng 4, 6708 WE, Wageningen, Wageningen 
      University, The Netherlands.
FAU - Kok, Dieuwertje E
AU  - Kok DE
AD  - Division of Human Nutrition, Stippeneng 4, 6708 WE, Wageningen, Wageningen 
      University, The Netherlands.
LA  - eng
PT  - Journal Article
DEP - 20170227
PL  - England
TA  - Environ Epigenet
JT  - Environmental epigenetics
JID - 101675941
PMC - PMC5804541
OTO - NOTNLM
OT  - DNA methylation
OT  - Illumina 450K BeadChip
OT  - PCBs
OT  - PFOS
OT  - dioxins
OT  - persistent organic pollutants
EDAT- 2018/03/02 06:00
MHDA- 2018/03/02 06:01
PMCR- 2017/02/27
CRDT- 2018/03/02 06:00
PHST- 2016/10/16 00:00 [received]
PHST- 2017/01/07 00:00 [revised]
PHST- 2017/01/17 00:00 [accepted]
PHST- 2018/03/02 06:00 [entrez]
PHST- 2018/03/02 06:00 [pubmed]
PHST- 2018/03/02 06:01 [medline]
PHST- 2017/02/27 00:00 [pmc-release]
AID - dvx001 [pii]
AID - 10.1093/eep/dvx001 [doi]
PST - epublish
SO  - Environ Epigenet. 2017 Feb 27;3(1):dvx001. doi: 10.1093/eep/dvx001. eCollection 
      2017 Jan.