PMID- 29492311
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20200930
IS  - 2058-5888 (Print)
IS  - 2058-5888 (Electronic)
IS  - 2058-5888 (Linking)
VI  - 3
IP  - 2
DP  - 2017 May
TI  - An emerging role for epigenetic regulation of Pgc-1alpha expression in 
      environmentally stimulated brown adipose thermogenesis.
PG  - dvx009
LID - 10.1093/eep/dvx009 [doi]
LID - dvx009
AB  - Metabolic disease is a leading cause of death worldwide, and obesity, a central 
      risk factor, is reaching epidemic proportions. Energy expenditure and brown 
      adipose tissue (BAT) thermogenesis are implicated in metabolic disease, and it is 
      becoming evident that impaired BAT activity is regulated by gene/environment 
      interactions. Peroxisome proliferator-activated receptor gamma coactivator 1alpha 
      (Pgc-1alpha) is a critical regulator of BAT thermogenesis, which is highly inducible 
      by environmental stimuli such as cold and diet. This review focuses on the 
      environmentally mediated epigenetic and transcriptional regulation of Pgc-1alpha gene 
      expression during BAT thermogenesis. We illustrate interactions between histone 
      modifications and transcription factors at the Pgc-1alpha promoter that cause BAT 
      Pgc-1alpha transcription in response to cold. Histone modifications also modulate BAT 
      Pgc-1alpha transcription in response to nutrients though diet has been less 
      characterized than cold with respect to regulation of Pgc-1alpha transcription. 
      Pgc-1alpha DNA methylation and RNA expression were also correlated to indicators of 
      adiposity and glucose homeostasis across numerous human tissues. Although 
      post-translational modification of Pgc-1alpha protein has been well-characterized 
      across diverse tissues and environments, comparatively little is known of the 
      epigenetic mechanisms regulating Pgc-1alpha transcription, particularly in BAT 
      thermogenesis.
FAU - Gill, J A
AU  - Gill JA
AD  - Department of Environmental Toxicology, Genome Center, and Integrated Genetics 
      and Genomics Graduate Group, University of California, Davis, CA, USA.
FAU - La Merrill, Michele A
AU  - La Merrill MA
AD  - Department of Environmental Toxicology, Genome Center, and Integrated Genetics 
      and Genomics Graduate Group, University of California, Davis, CA, USA.
LA  - eng
GR  - R01 ES024946/ES/NIEHS NIH HHS/United States
PT  - Journal Article
PT  - Review
DEP - 20170630
PL  - England
TA  - Environ Epigenet
JT  - Environmental epigenetics
JID - 101675941
PMC - PMC5804549
OTO - NOTNLM
OT  - brown adipose tissue
OT  - coactivator 1alpha
OT  - epigenetics
OT  - gene regulation
OT  - peroxisome proliferator-activated receptor gamma
OT  - thermogenesis
EDAT- 2018/03/02 06:00
MHDA- 2018/03/02 06:01
PMCR- 2017/06/30
CRDT- 2018/03/02 06:00
PHST- 2016/12/30 00:00 [received]
PHST- 2017/04/02 00:00 [revised]
PHST- 2017/04/20 00:00 [accepted]
PHST- 2018/03/02 06:00 [entrez]
PHST- 2018/03/02 06:00 [pubmed]
PHST- 2018/03/02 06:01 [medline]
PHST- 2017/06/30 00:00 [pmc-release]
AID - dvx009 [pii]
AID - 10.1093/eep/dvx009 [doi]
PST - epublish
SO  - Environ Epigenet. 2017 Jun 30;3(2):dvx009. doi: 10.1093/eep/dvx009. eCollection 
      2017 May.