PMID- 29492426 OWN - NLM STAT- PubMed-not-MEDLINE LR - 20200930 IS - 2363-9024 (Electronic) IS - 2363-9024 (Linking) VI - 2 IP - 1 DP - 2016 TI - Therapeutic plasma exchange in heart transplantation: role of coagulation assessment with thromboelastometry. PG - 31 LID - 10.1186/s40981-016-0058-1 [doi] LID - 31 AB - Therapeutic plasma exchange (TPE) is a potentially life-saving procedure which effectively removes donor-specific human leukocyte antigen (HLA) antibodies from the bloodstream, allowing critically ill heart transplant recipients to receive a donor organ with less wait time, and reducing the risk of acute organ rejection. The bulk of coagulation factors is initially removed from the blood during TPE using albumin and is later replaced with allogeneic plasma. Coagulopathy may develop during TPE and then can persist due to intraoperative blood loss and hemodilution during surgery and cardiopulmonary bypass. We hereby describe the utility of rotational thromboelastometry to assess rapid coagulation changes during TPE and subsequent heart transplant (HT) surgery. FAU - Crabbe, Andrew AU - Crabbe A AD - Department of Anesthesiology, University of Maryland, 22 South Greene Street, Suite S8D12, Baltimore, MD 21201 USA. FAU - McNeil, John S AU - McNeil JS AD - Department of Anesthesiology, University of Virginia, Charlottesville, VA USA. FAU - Deshpande, Seema P AU - Deshpande SP AD - Department of Anesthesiology, University of Maryland, 22 South Greene Street, Suite S8D12, Baltimore, MD 21201 USA. FAU - Kon, Zachary AU - Kon Z AD - Department of Surgery, Division of Cardiothoracic Surgery, University of Maryland, Baltimore, MD USA. FAU - Pham, Si M AU - Pham SM AD - Department of Surgery, Division of Cardiothoracic Surgery, University of Maryland, Baltimore, MD USA. FAU - Tanaka, Kenichi A AU - Tanaka KA AD - Department of Anesthesiology, University of Maryland, 22 South Greene Street, Suite S8D12, Baltimore, MD 21201 USA. LA - eng PT - Journal Article DEP - 20161019 PL - Germany TA - JA Clin Rep JT - JA clinical reports JID - 101682121 PMC - PMC5814793 OTO - NOTNLM OT - Coagulation OT - Coagulation factor deficiency OT - Fresh frozen plasma OT - Heart transplantation OT - Plasma exchange EDAT- 2016/01/01 00:00 MHDA- 2016/01/01 00:01 PMCR- 2016/10/19 CRDT- 2018/03/02 06:00 PHST- 2016/06/08 00:00 [received] PHST- 2016/10/11 00:00 [accepted] PHST- 2018/03/02 06:00 [entrez] PHST- 2016/01/01 00:00 [pubmed] PHST- 2016/01/01 00:01 [medline] PHST- 2016/10/19 00:00 [pmc-release] AID - 58 [pii] AID - 10.1186/s40981-016-0058-1 [doi] PST - ppublish SO - JA Clin Rep. 2016;2(1):31. doi: 10.1186/s40981-016-0058-1. Epub 2016 Oct 19.