PMID- 29494492
OWN - NLM
STAT- MEDLINE
DCOM- 20180827
LR  - 20211204
IS  - 1422-0067 (Electronic)
IS  - 1422-0067 (Linking)
VI  - 19
IP  - 3
DP  - 2018 Mar 1
TI  - Importance of ERK1/2 in Regulation of Protein Translation during Oocyte Meiosis.
LID - 10.3390/ijms19030698 [doi]
LID - 698
AB  - Although the involvement of the extracellular signal-regulated kinases 1 and 2 
      (ERK1/2) pathway in the regulation of cytostatic factor (CSF) activity; as well 
      as in microtubules organization during meiotic maturation of oocytes; has already 
      been described in detail; rather less attention has been paid to the role of 
      ERK1/2 in the regulation of mRNA translation. However; important data on the role 
      of ERK1/2 in translation during oocyte meiosis have been documented. This review 
      focuses on recent findings regarding the regulation of translation and the role 
      of ERK1/2 in this process in the meiotic cycle of mammalian oocytes. The specific 
      role of ERK1/2 in the regulation of mammalian target of rapamycin (mTOR); 
      eukaryotic translation initiation factor 4E (eIF4E) and cytoplasmic 
      polyadenylation element binding protein 1 (CPEB1) activity is addressed along 
      with additional focus on the other key players involved in protein translation.
FAU - Kalous, Jaroslav
AU  - Kalous J
AD  - Institute of Animal Physiology and Genetics, Academy of Sciences of the Czech 
      Republic, Rumburska 89, 27721 Libechov, Czech Republic. Kalous@iapg.cas.cz.
FAU - Tetkova, Anna
AU  - Tetkova A
AUID- ORCID: 0000-0003-4334-3268
AD  - Institute of Animal Physiology and Genetics, Academy of Sciences of the Czech 
      Republic, Rumburska 89, 27721 Libechov, Czech Republic. Tetkova@iapg.cas.cz.
AD  - Department of Cell Biology, Faculty of Science, Charles University in Prague, 
      Albertov 6, 12843 Prague 2, Czech Republic. Tetkova@iapg.cas.cz.
FAU - Kubelka, Michal
AU  - Kubelka M
AD  - Institute of Animal Physiology and Genetics, Academy of Sciences of the Czech 
      Republic, Rumburska 89, 27721 Libechov, Czech Republic. Kubelka@iapg.cas.cz.
FAU - Susor, Andrej
AU  - Susor A
AUID- ORCID: 0000-0003-2926-4096
AD  - Institute of Animal Physiology and Genetics, Academy of Sciences of the Czech 
      Republic, Rumburska 89, 27721 Libechov, Czech Republic. Susor@iapg.cas.cz.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20180301
PL  - Switzerland
TA  - Int J Mol Sci
JT  - International journal of molecular sciences
JID - 101092791
RN  - 0 (Eukaryotic Initiation Factor-4E)
RN  - 0 (RNA, Messenger)
RN  - 0 (mRNA Cleavage and Polyadenylation Factors)
RN  - EC 2.7.11.1 (TOR Serine-Threonine Kinases)
RN  - EC 2.7.11.24 (Mitogen-Activated Protein Kinase 1)
RN  - EC 2.7.11.24 (Mitogen-Activated Protein Kinase 3)
RN  - EC 2.7.11.24 (Mitogen-Activated Protein Kinases)
SB  - IM
MH  - Animals
MH  - Cytoplasm/genetics/metabolism
MH  - Eukaryotic Initiation Factor-4E/metabolism
MH  - Gene Expression Regulation, Developmental
MH  - Humans
MH  - *Meiosis
MH  - Mitogen-Activated Protein Kinase 1/*metabolism
MH  - Mitogen-Activated Protein Kinase 3/*metabolism
MH  - Mitogen-Activated Protein Kinases/metabolism
MH  - Oocytes/*metabolism
MH  - Phosphatidylinositol 3-Kinases/metabolism
MH  - Polyadenylation
MH  - Protein Binding
MH  - *Protein Biosynthesis
MH  - RNA, Messenger/genetics/metabolism
MH  - Signal Transduction
MH  - TOR Serine-Threonine Kinases/metabolism
MH  - mRNA Cleavage and Polyadenylation Factors/metabolism
PMC - PMC5877559
OTO - NOTNLM
OT  - CPEB1
OT  - ERK1/2
OT  - MAP kinase
OT  - eIF4E
OT  - mTOR
OT  - oocyte
OT  - translation
COIS- The authors declare no conflict of interest.
EDAT- 2018/03/02 06:00
MHDA- 2018/08/28 06:00
PMCR- 2018/03/01
CRDT- 2018/03/02 06:00
PHST- 2018/01/31 00:00 [received]
PHST- 2018/02/23 00:00 [revised]
PHST- 2018/02/26 00:00 [accepted]
PHST- 2018/03/02 06:00 [entrez]
PHST- 2018/03/02 06:00 [pubmed]
PHST- 2018/08/28 06:00 [medline]
PHST- 2018/03/01 00:00 [pmc-release]
AID - ijms19030698 [pii]
AID - ijms-19-00698 [pii]
AID - 10.3390/ijms19030698 [doi]
PST - epublish
SO  - Int J Mol Sci. 2018 Mar 1;19(3):698. doi: 10.3390/ijms19030698.