PMID- 29494605
OWN - NLM
STAT- MEDLINE
DCOM- 20180629
LR  - 20181114
IS  - 1932-6203 (Electronic)
IS  - 1932-6203 (Linking)
VI  - 13
IP  - 3
DP  - 2018
TI  - Copolymer-1 enhances cognitive performance in young adult rats.
PG  - e0192885
LID - 10.1371/journal.pone.0192885 [doi]
LID - e0192885
AB  - Cognitive impairment is a dysfunction observed as a sequel of various 
      neurodegenerative diseases, as well as a concomitant element in the elderly 
      stages of life. In clinical settings, this malfunction is identified as mild 
      cognitive impairment. Previous studies have suggested that cognitive impairment 
      could be the result of a reduction in the expression of brain-derived 
      neurotrophic factor (BDNF) and/or immune dysfunction. Copolymer-1 (Cop-1) is an 
      FDA-approved synthetic peptide capable of inducing the activation of Th2/3 cells, 
      which are able to release BDNF, as well as to migrate and accumulate in the 
      brain. In this study, we evaluated the effect of Cop-1 immunization on 
      improvement of cognition in adult rats. For this purpose, we performed four 
      experiments. We evaluated the effect of Cop-1 immunization on learning/memory 
      using the Morris water maze for spatial memory and autoshaping for associative 
      memory in 3- or 6-month-old rats. BDNF concentrations at the hippocampus were 
      determined by ELISA. Cop-1 immunization induced a significant improvement of 
      spatial memory and associative memory in 6-month-old rats. Likewise, Cop-1 
      improved spatial memory and associative memory when animals were immunized at 3 
      months and evaluated at 6 months old. Additionally, Cop-1 induced a significant 
      increase in BDNF levels at the hippocampus. To our knowledge, the present 
      investigation reports the first instance of Cop-1 treatment enhancing cognitive 
      function in normal young adult rats, suggesting that Cop-1 may be a practical 
      therapeutic strategy potentially useful for age- or disease-related cognitive 
      impairment.
FAU - Nieto-Vera, Rossana
AU  - Nieto-Vera R
AD  - Centro de Investigacion en Ciencias de la Salud (CICSA), Facultad de Ciencias de 
      la Salud, Universidad Anahuac Mexico Campus Norte; Av. Universidad Anahuac No. 
      46, Lomas Anahuac, Huixquilucan, Estado de Mexico, Mexico.
FAU - Kahuam-Lopez, Nicolas
AU  - Kahuam-Lopez N
AD  - Centro de Investigacion en Ciencias de la Salud (CICSA), Facultad de Ciencias de 
      la Salud, Universidad Anahuac Mexico Campus Norte; Av. Universidad Anahuac No. 
      46, Lomas Anahuac, Huixquilucan, Estado de Mexico, Mexico.
FAU - Meneses, Alfredo
AU  - Meneses A
AD  - Departamento de Farmacobiologia, CINVESTAV-IPN, Mexico City, Mexico.
FAU - Cruz-Martinez, Yolanda
AU  - Cruz-Martinez Y
AD  - Centro de Investigacion en Ciencias de la Salud (CICSA), Facultad de Ciencias de 
      la Salud, Universidad Anahuac Mexico Campus Norte; Av. Universidad Anahuac No. 
      46, Lomas Anahuac, Huixquilucan, Estado de Mexico, Mexico.
FAU - Anaya-Jimenez, Rosa Maria
AU  - Anaya-Jimenez RM
AD  - Departamento de Farmacobiologia, CINVESTAV-IPN, Mexico City, Mexico.
FAU - Liy-Salmeron, Gustavo
AU  - Liy-Salmeron G
AD  - Centro de Investigacion en Ciencias de la Salud (CICSA), Facultad de Ciencias de 
      la Salud, Universidad Anahuac Mexico Campus Norte; Av. Universidad Anahuac No. 
      46, Lomas Anahuac, Huixquilucan, Estado de Mexico, Mexico.
FAU - Carvajal, Horacio Guillermo
AU  - Carvajal HG
AD  - Centro de Investigacion en Ciencias de la Salud (CICSA), Facultad de Ciencias de 
      la Salud, Universidad Anahuac Mexico Campus Norte; Av. Universidad Anahuac No. 
      46, Lomas Anahuac, Huixquilucan, Estado de Mexico, Mexico.
FAU - Ponce-Lopez, Maria Teresa
AU  - Ponce-Lopez MT
AD  - Centro de Investigacion en Ciencias de la Salud (CICSA), Facultad de Ciencias de 
      la Salud, Universidad Anahuac Mexico Campus Norte; Av. Universidad Anahuac No. 
      46, Lomas Anahuac, Huixquilucan, Estado de Mexico, Mexico.
FAU - Ibarra, Antonio
AU  - Ibarra A
AUID- ORCID: 0000-0003-2489-4689
AD  - Centro de Investigacion en Ciencias de la Salud (CICSA), Facultad de Ciencias de 
      la Salud, Universidad Anahuac Mexico Campus Norte; Av. Universidad Anahuac No. 
      46, Lomas Anahuac, Huixquilucan, Estado de Mexico, Mexico.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20180301
PL  - United States
TA  - PLoS One
JT  - PloS one
JID - 101285081
RN  - 0 (Adjuvants, Immunologic)
RN  - 0 (Nootropic Agents)
RN  - 0 (Peptides)
SB  - IM
MH  - Adjuvants, Immunologic/administration & dosage/therapeutic use
MH  - Animals
MH  - Cognition/*drug effects
MH  - Cognition Disorders/etiology/prevention & control
MH  - Hippocampus/drug effects/physiology
MH  - Learning/drug effects
MH  - Male
MH  - Maze Learning/drug effects
MH  - Nootropic Agents/administration & dosage/*therapeutic use
MH  - Peptides/administration & dosage/*therapeutic use
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Spatial Memory/*drug effects
PMC - PMC5832204
COIS- Competing Interests: The authors have declared that no competing interests exist.
EDAT- 2018/03/02 06:00
MHDA- 2018/06/30 06:00
PMCR- 2018/03/01
CRDT- 2018/03/02 06:00
PHST- 2017/12/06 00:00 [received]
PHST- 2018/01/31 00:00 [accepted]
PHST- 2018/03/02 06:00 [entrez]
PHST- 2018/03/02 06:00 [pubmed]
PHST- 2018/06/30 06:00 [medline]
PHST- 2018/03/01 00:00 [pmc-release]
AID - PONE-D-17-42850 [pii]
AID - 10.1371/journal.pone.0192885 [doi]
PST - epublish
SO  - PLoS One. 2018 Mar 1;13(3):e0192885. doi: 10.1371/journal.pone.0192885. 
      eCollection 2018.