PMID- 29496054
OWN - NLM
STAT- MEDLINE
DCOM- 20191213
LR  - 20191217
IS  - 1879-0593 (Electronic)
IS  - 1368-8375 (Linking)
VI  - 78
DP  - 2018 Mar
TI  - Influence of anemia and BMI on prognosis of laryngeal squamous cell carcinoma: 
      Development of an updated prognostic model.
PG  - 25-30
LID - S1368-8375(18)30001-0 [pii]
LID - 10.1016/j.oraloncology.2018.01.001 [doi]
AB  - OBJECTIVE: evaluating the impact of anemia and body mass index (BMI) on survival, 
      and development of a prognostic model for overall survival for patients with 
      laryngeal squamous cell carcinoma (LSCC). MATERIALS AND METHODS: A retrospective 
      cohort study was performed including all consecutive patients with LSCC diagnosed 
      and treated at the Erasmus Medical Center between January 2006 and December 2013. 
      Patient- and tumor-specific data were collected using data from the Netherlands 
      Comprehensive Cancer Organization and supplemented with data from patient records 
      available in the Erasmus MC. All comorbidities were scored at the time of 
      diagnosis. RESULTS: in total 788 patients were included. Mean follow-up time was 
      50 months (SD: +/-30), during which 298 patients (37.8%) died. In both univariate 
      and multivariate analysis BMI and anemia were significant predictors for overall 
      survival. Multivariate analysis was performed using known predictors such as age, 
      TNM-stage and comorbidity (ACE-27). The hazard ratio of anemia was 1.41 (95% CI: 
      1.05-1.90) and of BMI was 0.97 (95% CI: 0.94-0.99). BMI had an inverse 
      association with overall survival in both univariate and multivariate survival 
      analysis. Updating and validating an existing prognostic model with addition of 
      anemia and BMI enhanced the performance of the prognostic model (C-statistic) 
      from 0.77 (95% CI: 0.74-0.79) to 0.79 (95% CI: 0.77-0.82). CONCLUSION: anemia and 
      BMI are predictors of overall survival for LSCC, independent of other known 
      predictors of overall survival. Adding anemia and BMI to an existing prognostic 
      model provides better prediction of overall survival.
CI  - Copyright (c) 2018 Elsevier Ltd. All rights reserved.
FAU - Te Riele, R J L M
AU  - Te Riele RJLM
AD  - Department of Otorhinolaryngology and Head and Neck Surgery, Erasmus MC Cancer 
      Institute, The Netherlands.
FAU - Dronkers, E A C
AU  - Dronkers EAC
AD  - Department of Otorhinolaryngology and Head and Neck Surgery, Erasmus MC Cancer 
      Institute, The Netherlands. Electronic address: e.dronkers@erasmusmc.nl.
FAU - Wieringa, M H
AU  - Wieringa MH
AD  - Department of Otorhinolaryngology and Head and Neck Surgery, Erasmus MC Cancer 
      Institute, The Netherlands.
FAU - De Herdt, M J
AU  - De Herdt MJ
AD  - Department of Otorhinolaryngology and Head and Neck Surgery, Erasmus MC Cancer 
      Institute, The Netherlands.
FAU - Sewnaik, A
AU  - Sewnaik A
AD  - Department of Otorhinolaryngology and Head and Neck Surgery, Erasmus MC Cancer 
      Institute, The Netherlands.
FAU - Hardillo, J A
AU  - Hardillo JA
AD  - Department of Otorhinolaryngology and Head and Neck Surgery, Erasmus MC Cancer 
      Institute, The Netherlands.
FAU - Baatenburg de Jong, R J
AU  - Baatenburg de Jong RJ
AD  - Department of Otorhinolaryngology and Head and Neck Surgery, Erasmus MC Cancer 
      Institute, The Netherlands.
LA  - eng
PT  - Journal Article
DEP - 20180111
PL  - England
TA  - Oral Oncol
JT  - Oral oncology
JID - 9709118
SB  - IM
MH  - Adult
MH  - Aged
MH  - Anemia/*pathology
MH  - *Body Mass Index
MH  - Carcinoma, Squamous Cell/*pathology
MH  - Female
MH  - Humans
MH  - Laryngeal Neoplasms/*pathology
MH  - Male
MH  - Middle Aged
MH  - *Models, Biological
MH  - Prognosis
MH  - Retrospective Studies
MH  - Survival Analysis
OTO - NOTNLM
OT  - ACE27 comorbidity index
OT  - Anemia
OT  - Body mass index
OT  - Comorbidity
OT  - Head and neck carcinoma
OT  - Laryngeal carcinoma
OT  - Overall survival
OT  - Prognostic model
OT  - Weight loss
EDAT- 2018/03/03 06:00
MHDA- 2019/12/18 06:00
CRDT- 2018/03/03 06:00
PHST- 2017/09/18 00:00 [received]
PHST- 2017/12/06 00:00 [revised]
PHST- 2018/01/06 00:00 [accepted]
PHST- 2018/03/03 06:00 [entrez]
PHST- 2018/03/03 06:00 [pubmed]
PHST- 2019/12/18 06:00 [medline]
AID - S1368-8375(18)30001-0 [pii]
AID - 10.1016/j.oraloncology.2018.01.001 [doi]
PST - ppublish
SO  - Oral Oncol. 2018 Mar;78:25-30. doi: 10.1016/j.oraloncology.2018.01.001. Epub 2018 
      Jan 11.