PMID- 29496189
OWN - NLM
STAT- MEDLINE
DCOM- 20180403
LR  - 20181202
IS  - 1873-3778 (Electronic)
IS  - 0021-9673 (Linking)
VI  - 1542
DP  - 2018 Mar 23
TI  - Optimization and application of parallel solid-phase extraction coupled with 
      ultra-high performance liquid chromatography-tandem mass spectrometry for the 
      determination of 11 aminoglycoside residues in honey and royal jelly.
PG  - 28-36
LID - S0021-9673(18)30211-5 [pii]
LID - 10.1016/j.chroma.2018.02.029 [doi]
AB  - A robust and sensitive method of solid-phase extraction followed by liquid 
      chromatography-tandem mass spectrometry (LC-MS/MS) was established and performed 
      for the simultaneous determination of eleven aminoglycosides (AGs) in royal jelly 
      and honey. After sample extraction by a phosphate buffer containing 
      trichloroacetic acid (TCA) and ethylenediaminetetracetic acid disodium salt 
      (Na(2)EDTA), the extraction solution was subjected to a parallel solid-phase 
      extraction for clean-up prior to the LC-MS/MS analysis. The same method was 
      applied to analyze two completely different matrices, honey and royal jelly. Good 
      sensitivity, repeatability, and recovery were obtained by using the mobile phase 
      without an ion-pairing reagent such as heptafluorobutyric acid (HFBA) or sodium 
      heptanesulfonate. The calibration curves of the honey and royal jelly samples 
      exhibited a good linear response (R(2) > 0.99) at six concentrations in the range 
      of 10-1000 mug/mL. The limit of quantification (LOQ) of the AGs ranged from 10 to 
      25 mug/kg in the honey and from 12.5 to 25 mug/kg in the royal jelly. The 
      recoveries of the AGs for the honey and royal jelly samples were in the range of 
      79.48% to 108.95% and 74.61% to 113.70% respectively and the relative standard 
      deviations (RSDs) were between 1.23% and 9.59%, and between 1.51% and 9.98%, 
      respectively. The proposed approach has been allowed in China as a reference 
      method for the simultaneous determination of eleven AGs in honey and royal jelly.
CI  - Copyright (c) 2018 Elsevier B.V. All rights reserved.
FAU - Wang, Xinran
AU  - Wang X
AD  - Institute of Apicultural Research, Chinese Academy of Agricultural Sciences, 
      Beijing 100093, PR China.
FAU - Yang, Shupeng
AU  - Yang S
AD  - Institute of Apicultural Research, Chinese Academy of Agricultural Sciences, 
      Beijing 100093, PR China; Laboratory of Risk Assessment for Quality and Safety of 
      Bee Products, Ministry of Agriculture, Beijing 100093, PR China; Key Laboratory 
      of Bee Products for Quality and Safety Control, Ministry of Agriculture, Beijing 
      100093, PR China; Bee Product Quality Supervision and Testing Centre, Ministry of 
      Agriculture, Beijing 100093, PR China.
FAU - Li, Yi
AU  - Li Y
AD  - Institute of Apicultural Research, Chinese Academy of Agricultural Sciences, 
      Beijing 100093, PR China; Laboratory of Risk Assessment for Quality and Safety of 
      Bee Products, Ministry of Agriculture, Beijing 100093, PR China; Key Laboratory 
      of Bee Products for Quality and Safety Control, Ministry of Agriculture, Beijing 
      100093, PR China; Bee Product Quality Supervision and Testing Centre, Ministry of 
      Agriculture, Beijing 100093, PR China.
FAU - Zhang, Jinzhen
AU  - Zhang J
AD  - Institute of Apicultural Research, Chinese Academy of Agricultural Sciences, 
      Beijing 100093, PR China; Laboratory of Risk Assessment for Quality and Safety of 
      Bee Products, Ministry of Agriculture, Beijing 100093, PR China; Key Laboratory 
      of Bee Products for Quality and Safety Control, Ministry of Agriculture, Beijing 
      100093, PR China; Bee Product Quality Supervision and Testing Centre, Ministry of 
      Agriculture, Beijing 100093, PR China.
FAU - Jin, Yue
AU  - Jin Y
AD  - Institute of Apicultural Research, Chinese Academy of Agricultural Sciences, 
      Beijing 100093, PR China; Laboratory of Risk Assessment for Quality and Safety of 
      Bee Products, Ministry of Agriculture, Beijing 100093, PR China; Key Laboratory 
      of Bee Products for Quality and Safety Control, Ministry of Agriculture, Beijing 
      100093, PR China; Bee Product Quality Supervision and Testing Centre, Ministry of 
      Agriculture, Beijing 100093, PR China.
FAU - Zhao, Wen
AU  - Zhao W
AD  - Institute of Apicultural Research, Chinese Academy of Agricultural Sciences, 
      Beijing 100093, PR China; Laboratory of Risk Assessment for Quality and Safety of 
      Bee Products, Ministry of Agriculture, Beijing 100093, PR China; Key Laboratory 
      of Bee Products for Quality and Safety Control, Ministry of Agriculture, Beijing 
      100093, PR China; Bee Product Quality Supervision and Testing Centre, Ministry of 
      Agriculture, Beijing 100093, PR China.
FAU - Zhang, Yongxin
AU  - Zhang Y
AD  - Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, 
      Beijing 100700, PR China.
FAU - Huang, Jingping
AU  - Huang J
AD  - Institute of Apicultural Research, Chinese Academy of Agricultural Sciences, 
      Beijing 100093, PR China; Laboratory of Risk Assessment for Quality and Safety of 
      Bee Products, Ministry of Agriculture, Beijing 100093, PR China; Key Laboratory 
      of Bee Products for Quality and Safety Control, Ministry of Agriculture, Beijing 
      100093, PR China; Bee Product Quality Supervision and Testing Centre, Ministry of 
      Agriculture, Beijing 100093, PR China.
FAU - Wang, Peng
AU  - Wang P
AD  - Institute of Apicultural Research, Chinese Academy of Agricultural Sciences, 
      Beijing 100093, PR China; Laboratory of Risk Assessment for Quality and Safety of 
      Bee Products, Ministry of Agriculture, Beijing 100093, PR China; Key Laboratory 
      of Bee Products for Quality and Safety Control, Ministry of Agriculture, Beijing 
      100093, PR China; Bee Product Quality Supervision and Testing Centre, Ministry of 
      Agriculture, Beijing 100093, PR China.
FAU - Wu, Cuiling
AU  - Wu C
AD  - Agilent Technologies Inc., Beijing 100102, PR China.
FAU - Zhou, Jinhui
AU  - Zhou J
AD  - Institute of Apicultural Research, Chinese Academy of Agricultural Sciences, 
      Beijing 100093, PR China; Laboratory of Risk Assessment for Quality and Safety of 
      Bee Products, Ministry of Agriculture, Beijing 100093, PR China; Key Laboratory 
      of Bee Products for Quality and Safety Control, Ministry of Agriculture, Beijing 
      100093, PR China; Bee Product Quality Supervision and Testing Centre, Ministry of 
      Agriculture, Beijing 100093, PR China. Electronic address: zhoujinhui@caas.cn.
LA  - eng
PT  - Journal Article
DEP - 20180219
PL  - Netherlands
TA  - J Chromatogr A
JT  - Journal of chromatography. A
JID - 9318488
RN  - 0 (Aminoglycosides)
RN  - 0 (Fatty Acids)
RN  - L497I37F0C (royal jelly)
SB  - IM
MH  - Aminoglycosides/*analysis
MH  - China
MH  - *Chromatography, High Pressure Liquid
MH  - Fatty Acids/*chemistry
MH  - Food Analysis/*methods
MH  - Honey/*analysis
MH  - Limit of Detection
MH  - *Solid Phase Extraction
MH  - *Tandem Mass Spectrometry
OTO - NOTNLM
OT  - Aminoglycosides
OT  - Honey and royal jelly
OT  - LC-MS/MS
OT  - Parallel solid-phase extraction
EDAT- 2018/03/03 06:00
MHDA- 2018/04/04 06:00
CRDT- 2018/03/03 06:00
PHST- 2017/12/04 00:00 [received]
PHST- 2018/02/07 00:00 [revised]
PHST- 2018/02/17 00:00 [accepted]
PHST- 2018/03/03 06:00 [pubmed]
PHST- 2018/04/04 06:00 [medline]
PHST- 2018/03/03 06:00 [entrez]
AID - S0021-9673(18)30211-5 [pii]
AID - 10.1016/j.chroma.2018.02.029 [doi]
PST - ppublish
SO  - J Chromatogr A. 2018 Mar 23;1542:28-36. doi: 10.1016/j.chroma.2018.02.029. Epub 
      2018 Feb 19.