PMID- 29496271
OWN - NLM
STAT- MEDLINE
DCOM- 20181024
LR  - 20181024
IS  - 1768-3122 (Electronic)
IS  - 0248-8663 (Linking)
VI  - 39
IP  - 5
DP  - 2018 May
TI  - [Antimalarial drug retinopathy].
PG  - 364-368
LID - S0248-8663(18)30049-3 [pii]
LID - 10.1016/j.revmed.2018.02.013 [doi]
AB  - INTRODUCTION: Antimalarial drugs are largely used for the treatment of various 
      systemic diseases. They can cause toxic retinopathy, which can lead to blindness. 
      OBSERVATION: We report the case of a 32-year-old male with a systemic lupus 
      erythematosus treated with hydroxychloroquine 400mg per day and then chloroquine 
      300mg per day during 8 and 9years respectively. Eighteen months after his latest 
      visual examination, the patient experienced bilateral vision loss. Fundus 
      examination revealed a bull's eye maculopathy. Additional tests including 
      multifocal electroretinogram showed severe bilateral functional impairment in the 
      parafoveal area leading to diagnosis of severe toxic retinopathy induced by 
      antimalarial drugs. DISCUSSION: In 2016, the American Academy of Ophthalmology 
      revised the previous 2011 recommendations concerning early retinal toxicity 
      screening strategy which should be first based on both automated 10-2 visual 
      fields and spectral-domain optical coherence tomography (SD OCT). Multifocal 
      electroretinogram can be more helpful for diagnostic confirmation rather than 
      screening. Although these recommendations are essential, they are not well known 
      in clinical practice.
CI  - Copyright (c) 2018 Societe Nationale Francaise de Medecine Interne (SNFMI). 
      Published by Elsevier SAS. All rights reserved.
FAU - Guiot, A
AU  - Guiot A
AD  - Hospices civils de Lyon, centre Hospitalier Lyon Sud, departement de 
      Rhumatologie, 69310 Pierre-Benite, France; Universite Lyon 1, Lyon, France. 
      Electronic address: anais.guiot@chu-lyon.fr.
FAU - Couturier, M
AU  - Couturier M
AD  - Hospices civils de Lyon, centre Hospitalier Lyon Sud, departement de 
      Rhumatologie, 69310 Pierre-Benite, France; Universite Lyon 1, Lyon, France.
FAU - Tebib, J G
AU  - Tebib JG
AD  - Hospices civils de Lyon, centre Hospitalier Lyon Sud, departement de 
      Rhumatologie, 69310 Pierre-Benite, France; Universite Lyon 1, Lyon, France.
FAU - Abouaf, L
AU  - Abouaf L
AD  - Hospices civils de Lyon, unite de neuro-ophtalmologie, hopital neurologique 
      Pierre-Wertheimer, groupement hospitalier Est, 69500 Bron, France.
FAU - Coury, F
AU  - Coury F
AD  - Hospices civils de Lyon, centre Hospitalier Lyon Sud, departement de 
      Rhumatologie, 69310 Pierre-Benite, France; Universite Lyon 1, Lyon, France.
LA  - fre
PT  - Case Reports
PT  - Journal Article
TT  - Retinopathie severe aux antipaludeens de synthese.
DEP - 20180226
PL  - France
TA  - Rev Med Interne
JT  - La Revue de medecine interne
JID - 8101383
RN  - 0 (Antimalarials)
RN  - 4QWG6N8QKH (Hydroxychloroquine)
RN  - 886U3H6UFF (Chloroquine)
SB  - IM
MH  - Adult
MH  - Antimalarials/*adverse effects
MH  - Chloroquine/*adverse effects
MH  - Electroretinography
MH  - Humans
MH  - Hydroxychloroquine/*adverse effects
MH  - Lupus Erythematosus, Systemic/drug therapy
MH  - Male
MH  - Retinal Diseases/*chemically induced
MH  - Tomography, Optical Coherence
MH  - Vision Disorders/*chemically induced
OTO - NOTNLM
OT  - Antimalarial drug
OT  - Antipaludeens de synthese
OT  - Electroretinogram
OT  - Lupus erythemateux systemique
OT  - Retinopathy
OT  - Retinopathie toxique
OT  - Systemic lupus erythematosus
OT  - Electroretinogramme
EDAT- 2018/03/03 06:00
MHDA- 2018/10/26 06:00
CRDT- 2018/03/03 06:00
PHST- 2017/05/23 00:00 [received]
PHST- 2018/01/23 00:00 [revised]
PHST- 2018/02/04 00:00 [accepted]
PHST- 2018/03/03 06:00 [pubmed]
PHST- 2018/10/26 06:00 [medline]
PHST- 2018/03/03 06:00 [entrez]
AID - S0248-8663(18)30049-3 [pii]
AID - 10.1016/j.revmed.2018.02.013 [doi]
PST - ppublish
SO  - Rev Med Interne. 2018 May;39(5):364-368. doi: 10.1016/j.revmed.2018.02.013. Epub 
      2018 Feb 26.