PMID- 29496614 OWN - NLM STAT- MEDLINE DCOM- 20190125 LR - 20190125 IS - 1095-9572 (Electronic) IS - 1053-8119 (Linking) VI - 173 DP - 2018 Jun TI - Segregation of the human basal forebrain using resting state functional MRI. PG - 287-297 LID - S1053-8119(18)30139-3 [pii] LID - 10.1016/j.neuroimage.2018.02.042 [doi] AB - The basal forebrain (BF) is poised to play an important neuromodulatory role in brain regions important to cognition due to its broad projections and complex neurochemistry. While significant in vivo work has been done to elaborate BF function in nonhuman rodents and primates, comparatively limited work has examined the in vivo function of the human BF. In the current study we used multi-echo resting state functional magnetic resonance imaging (rs-fMRI) from 100 young adults (18-34 years) to assess the potential segregation of human BF nuclei as well as their associated projections. Multi-echo processing provided significant gains in SNR throughout the brain as compared to traditional single-echo processing, with some of the largest increases observed in the BF. Bottom-up clustering of voxel-wise BF functional connectivity maps yielded adjacent functional clusters within the BF that closely aligned with the distinct, hypothesized nuclei important to cognition: the nucleus basalis of Meynert (NBM) and the medial septum/diagonal band of Broca (MS/DB). Examining their separate functional connections, the NBM and MS/DB revealed distinct projection patterns, suggesting a conservation of nuclei-specific functional connectivity with homologous regions known to be anatomically innervated by the BF. Specifically, the NBM demonstrated coupling with a widespread cortical network as well as the amygdala, whereas the MS/DB revealed coupling with a more circumscribed network, including the orbitofrontal cortex and hippocampal complex. Collectively, these in vivo rs-fMRI data demonstrate that the human BF nuclei support distinct aspects of resting-state functional networks, suggesting that the human BF may be a neuromodulatory hub important for orchestrating network dynamics. CI - Copyright (c) 2018 The Authors. Published by Elsevier Inc. All rights reserved. FAU - Markello, Ross D AU - Markello RD AD - Department of Human Development, Cornell University, Ithaca, NY, USA; Human Neuroscience Institute, Cornell University, Ithaca, NY, USA; Montreal Neurological Institute, Department of Neurology and Neurosurgery, McGill University, Montreal, QC, Canada. Electronic address: rossmarkello@gmail.com. FAU - Spreng, R Nathan AU - Spreng RN AD - Department of Human Development, Cornell University, Ithaca, NY, USA; Human Neuroscience Institute, Cornell University, Ithaca, NY, USA; Montreal Neurological Institute, Department of Neurology and Neurosurgery, McGill University, Montreal, QC, Canada. FAU - Luh, Wen-Ming AU - Luh WM AD - Cornell MRI Facility, Cornell University, Ithaca, NY, USA. FAU - Anderson, Adam K AU - Anderson AK AD - Department of Human Development, Cornell University, Ithaca, NY, USA; Human Neuroscience Institute, Cornell University, Ithaca, NY, USA. FAU - De Rosa, Eve AU - De Rosa E AD - Department of Human Development, Cornell University, Ithaca, NY, USA; Human Neuroscience Institute, Cornell University, Ithaca, NY, USA. Electronic address: edd56@cornell.edu. LA - eng GR - 1S10RR025145/NH/NIH HHS/United States PT - Journal Article PT - Research Support, N.I.H., Extramural PT - Research Support, Non-U.S. Gov't DEP - 20180226 PL - United States TA - Neuroimage JT - NeuroImage JID - 9215515 SB - IM MH - Adolescent MH - Adult MH - Basal Forebrain/*anatomy & histology MH - Female MH - Humans MH - Image Processing, Computer-Assisted/*methods MH - Magnetic Resonance Imaging/*methods MH - Male MH - Neural Pathways/*anatomy & histology MH - Young Adult OTO - NOTNLM OT - Basal forebrain OT - Functional networks OT - Multi-echo OT - Resting state functional MRI EDAT- 2018/03/03 06:00 MHDA- 2019/01/27 06:00 CRDT- 2018/03/03 06:00 PHST- 2017/10/30 00:00 [received] PHST- 2018/02/19 00:00 [revised] PHST- 2018/02/21 00:00 [accepted] PHST- 2018/03/03 06:00 [pubmed] PHST- 2019/01/27 06:00 [medline] PHST- 2018/03/03 06:00 [entrez] AID - S1053-8119(18)30139-3 [pii] AID - 10.1016/j.neuroimage.2018.02.042 [doi] PST - ppublish SO - Neuroimage. 2018 Jun;173:287-297. doi: 10.1016/j.neuroimage.2018.02.042. Epub 2018 Feb 26.