PMID- 29497131
OWN - NLM
STAT- MEDLINE
DCOM- 20191029
LR  - 20191029
IS  - 2045-2322 (Electronic)
IS  - 2045-2322 (Linking)
VI  - 8
IP  - 1
DP  - 2018 Mar 1
TI  - PDE4D regulates Spine Plasticity and Memory in the Retrosplenial Cortex.
PG  - 3895
LID - 10.1038/s41598-018-22193-0 [doi]
LID - 3895
AB  - The retrosplenial cortex (RSC) plays a critical role in episodic memory, but the 
      molecular mechanisms governing plasticity in this structure are poorly 
      understood. Diverse studies have demonstrated a role for RSC in acquisition, 
      early consolidation and retrieval similar to the hippocampus (HC), as well as in 
      systems consolidation similar to the anterior cingulate cortex. Here, we asked 
      whether established molecular and structural substrates of memory consolidation 
      in the HC also engage in RSC shortly after learning. We show striking parallels 
      in training induced gene-activation in HC and RSC following contextual 
      conditioning, which is blocked by systemic administration of an NMDA receptor 
      antagonist. Long-term memory is enhanced by retrosplenial and hippocampal 
      knockdown (KD) of the cAMP specific phosphodiesterase Pde4d. However, while 
      training per se induces lasting spine changes in HC, this does not occur in RSC. 
      Instead, increases in the number of mature dendritic spines are found in the RSC 
      only if cAMP signaling is augmented by Pde4d KD, and spine changes are at least 
      partially independent of training. This research highlights parallels and 
      differences in spine plasticity mechanisms between HC and RSC, and provides 
      evidence for a functional dissociation of the two.
FAU - Baumgartel, Karsten
AU  - Baumgartel K
AD  - Dart Neuroscience, LLC, 12278, Scripps Summit Drive, San Diego, CA, 92131, USA.
FAU - Green, Andrea
AU  - Green A
AD  - Dart Neuroscience, LLC, 12278, Scripps Summit Drive, San Diego, CA, 92131, USA.
FAU - Hornberger, Diana
AU  - Hornberger D
AD  - Dart Neuroscience, LLC, 12278, Scripps Summit Drive, San Diego, CA, 92131, USA.
FAU - Lapira, Jennifer
AU  - Lapira J
AD  - Dart Neuroscience, LLC, 12278, Scripps Summit Drive, San Diego, CA, 92131, USA.
FAU - Rex, Christopher
AU  - Rex C
AD  - Afraxis Inc., 6605, Nancy Ridge Rd. Suite 224, San Diego, CA, 92121, USA.
FAU - Wheeler, Damian G
AU  - Wheeler DG
AD  - Dart Neuroscience, LLC, 12278, Scripps Summit Drive, San Diego, CA, 92131, USA.
FAU - Peters, Marco
AU  - Peters M
AD  - Dart Neuroscience, LLC, 12278, Scripps Summit Drive, San Diego, CA, 92131, USA. 
      dr.marco.peters@gmail.com.
LA  - eng
GR  - P30 NS047101/NS/NINDS NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
DEP - 20180301
PL  - England
TA  - Sci Rep
JT  - Scientific reports
JID - 101563288
RN  - 0 (Receptors, N-Methyl-D-Aspartate)
RN  - EC 3.1.4.17 (Cyclic Nucleotide Phosphodiesterases, Type 4)
RN  - EC 3.1.4.17 (PDE4D protein, mouse)
SB  - IM
MH  - Animals
MH  - Cerebral Cortex/*metabolism
MH  - Cyclic Nucleotide Phosphodiesterases, Type 4/*metabolism
MH  - Fear/physiology
MH  - Gyrus Cinguli/metabolism
MH  - Hippocampus/metabolism
MH  - Male
MH  - Memory/*physiology
MH  - Memory Consolidation/physiology
MH  - Memory, Long-Term/physiology
MH  - Mice
MH  - Mice, Inbred C57BL
MH  - Neuronal Plasticity/physiology
MH  - Receptors, N-Methyl-D-Aspartate/antagonists & inhibitors/metabolism
PMC - PMC5832851
COIS- The authors declare no competing interests.
EDAT- 2018/03/03 06:00
MHDA- 2019/10/30 06:00
PMCR- 2018/03/01
CRDT- 2018/03/03 06:00
PHST- 2017/08/17 00:00 [received]
PHST- 2018/02/16 00:00 [accepted]
PHST- 2018/03/03 06:00 [entrez]
PHST- 2018/03/03 06:00 [pubmed]
PHST- 2019/10/30 06:00 [medline]
PHST- 2018/03/01 00:00 [pmc-release]
AID - 10.1038/s41598-018-22193-0 [pii]
AID - 22193 [pii]
AID - 10.1038/s41598-018-22193-0 [doi]
PST - epublish
SO  - Sci Rep. 2018 Mar 1;8(1):3895. doi: 10.1038/s41598-018-22193-0.