PMID- 29497582
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220316
IS  - 2164-2591 (Print)
IS  - 2164-2591 (Electronic)
IS  - 2164-2591 (Linking)
VI  - 7
IP  - 1
DP  - 2018 Feb
TI  - New Normative Database of Inner Macular Layer Thickness Measured by Spectralis 
      OCT Used as Reference Standard for Glaucoma Detection.
PG  - 20
LID - 10.1167/tvst.7.1.20 [doi]
LID - 20
AB  - PURPOSE: This study examines the capacity to detect glaucoma of inner macular 
      layer thickness measured by spectral-domain optical coherence tomography (SD-OCT) 
      using a new normative database as the reference standard. METHODS: Participants 
      (N = 148) were recruited from Leuven (Belgium) and Zaragoza (Spain): 74 patients 
      with early/moderate glaucoma and 74 age-matched healthy controls. One eye was 
      randomly selected for a macular scan using the Spectralis SD-OCT. The variables 
      measured with the instrument's segmentation software were: macular nerve fiber 
      layer (mRNFL), ganglion cell layer (GCL), and inner plexiform layer (IPL) volume 
      and thickness along with circumpapillary RNFL thickness (cpRNFL). The new 
      normative database of macular variables was used to define the cutoff of 
      normality as the fifth percentile by age group. Sensitivity, specificity, and 
      area under the receiver operating characteristic curve (AUROC) of each macular 
      measurement and of cpRNFL were used to distinguish between patients and controls. 
      RESULTS: Overall sensitivity and specificity to detect early-moderate glaucoma 
      were 42.2% and 88.9% for mRNFL, 42.4% and 95.6% for GCL, 42.2% and 94.5% for IPL, 
      and 53% and 94.6% for RNFL, respectively. The best macular variable to 
      discriminate between the two groups of subjects was outer temporal GCL thickness 
      as indicated by an AUROC of 0.903. This variable performed similarly to mean 
      cpRNFL thickness (AUROC = 0.845; P = 0.29). CONCLUSIONS: Using our normative 
      database as reference, the diagnostic power of inner macular layer thickness 
      proved comparable to that of peripapillary RNFL thickness. TRANSLATIONAL 
      RELEVANCE: Spectralis SD-OCT, cpRNFL thickness, and individual macular inner 
      layer thicknesses show comparable diagnostic capacity for glaucoma and RNFL, GCL, 
      and IPL thickness may be useful as an alternative diagnostic test when the 
      measure of cpRNFL shows artifacts.
FAU - Nieves-Moreno, Maria
AU  - Nieves-Moreno M
AD  - Ophthalmology Unit, Hospital Clinico San Carlos, Department of Ophthalmology, 
      Universidad Complutense de Madrid, Madrid, Spain.
AD  - Health Research Institute of the Hospital Clinico San Carlos, Madrid, Spain.
FAU - Martinez-de-la-Casa, Jose M
AU  - Martinez-de-la-Casa JM
AD  - Ophthalmology Unit, Hospital Clinico San Carlos, Department of Ophthalmology, 
      Universidad Complutense de Madrid, Madrid, Spain.
AD  - Health Research Institute of the Hospital Clinico San Carlos, Madrid, Spain.
FAU - Bambo, Maria P
AU  - Bambo MP
AD  - Ophthalmology Unit, Hospital Miguel Servet, Zaragoza, Spain.
FAU - Morales-Fernandez, Laura
AU  - Morales-Fernandez L
AD  - Ophthalmology Unit, Hospital Clinico San Carlos, Department of Ophthalmology, 
      Universidad Complutense de Madrid, Madrid, Spain.
AD  - Health Research Institute of the Hospital Clinico San Carlos, Madrid, Spain.
FAU - Van Keer, Karel
AU  - Van Keer K
AD  - Glaucoma Clinic UZ Leuven, Ophthalmology Research Group KU Leuven, Belgium.
FAU - Vandewalle, Evelien
AU  - Vandewalle E
AD  - Glaucoma Clinic UZ Leuven, Ophthalmology Research Group KU Leuven, Belgium.
FAU - Stalmans, Ingeborg
AU  - Stalmans I
AD  - Glaucoma Clinic UZ Leuven, Ophthalmology Research Group KU Leuven, Belgium.
FAU - Garcia-Feijoo, Julian
AU  - Garcia-Feijoo J
AD  - Ophthalmology Unit, Hospital Clinico San Carlos, Department of Ophthalmology, 
      Universidad Complutense de Madrid, Madrid, Spain.
AD  - Health Research Institute of the Hospital Clinico San Carlos, Madrid, Spain.
LA  - eng
PT  - Journal Article
DEP - 20180228
PL  - United States
TA  - Transl Vis Sci Technol
JT  - Translational vision science & technology
JID - 101595919
PMC - PMC5829952
OTO - NOTNLM
OT  - Spectralis-OCT
OT  - ganglion cell layer
OT  - inner plexiform layer
OT  - retinal nerve fiber layer
EDAT- 2018/03/03 06:00
MHDA- 2018/03/03 06:01
PMCR- 2018/02/28
CRDT- 2018/03/03 06:00
PHST- 2017/10/17 00:00 [received]
PHST- 2018/01/04 00:00 [accepted]
PHST- 2018/03/03 06:00 [entrez]
PHST- 2018/03/03 06:00 [pubmed]
PHST- 2018/03/03 06:01 [medline]
PHST- 2018/02/28 00:00 [pmc-release]
AID - TVST-17-0630R1 [pii]
AID - 10.1167/tvst.7.1.20 [doi]
PST - epublish
SO  - Transl Vis Sci Technol. 2018 Feb 28;7(1):20. doi: 10.1167/tvst.7.1.20. 
      eCollection 2018 Feb.