PMID- 29497684 OWN - NLM STAT- PubMed-not-MEDLINE LR - 20220330 IS - 2364-3722 (Print) IS - 2196-9736 (Electronic) IS - 2196-9736 (Linking) VI - 6 IP - 3 DP - 2018 Mar TI - Multicenter experience from the UK and Ireland of use of lumen-apposing metal stent for transluminal drainage of pancreatic fluid collections. PG - E259-E265 LID - 10.1055/s-0043-125362 [doi] AB - BACKGROUND AND STUDY AIMS: Pancreatic fluid collection (PFC) is a common complication of pancreatitis for which endoscopic ultrasound-guided drainage is first-line treatment. A new single-device, lumen-apposing, covered self-expanding metal stent (LAMS) has been licensed for PFC drainage. We therefore present our multicenter experience with the LAMS for PFC drainage in a multicenter prospective case series to assess success and complication rates. PATIENTS AND METHODS: All adult patients from 11 tertiary centers who had LAMS placement for PFC from July 2015 to July 2016 were included. Data including indications, technical success, clinical success, collection resolution, stent removal, early and late adverse events (AEs), mortality and recurrence at 6 months were collected. RESULTS: 116 patients, median age 52.5 years (range 16 - 80) and 67 % male, were treated with a single LAMS in each case. The indication was walled off necrosis (WON) in 70 and pseudocyst in 46. Median size of the PFC was 11 cm (5 - 21 cm) and the estimated median necrotic volume in WON was 30 % (5 % - 90 %). Stent insertion was technically successful in 115 (99.1 %) and clinically successful in 109 (94 %). Early serious AEs (SAEs): n = 7 sepsis, n = 1 stent blockage with food, n = 1 stent migration requiring laparotomy, n = 1 stent dislodgement and n = 1 bleeding requiring emboliZation. Late AEs: n = 1 buried stent and n = 1 esophageal fistula. Non-procedure-related deaths: n = 3 (2.5 %). CONCLUSION: This multicenter case series demonstrates that use of the new LAMS is feasible, effective and relatively safe in draining PFC with a technical success rate of 99 % and cumulative SAE rate of 11.2 %. FAU - Venkatachalapathy, Suresh Vasan AU - Venkatachalapathy SV AD - Nottingham University Hospitals NHS Trust And University Of Nottingham - Nottingham Biomedical Research Centre and NIHR Nottingham Biomedical Research Centre, Nottingham, United Kingdom of Great Britain and Northern Ireland. FAU - Bekkali, Noor AU - Bekkali N AD - Freeman Hospital - HPB Unit, Newcastle upon Tyne, Newcastle upon Tyne, United Kingdom of Great Britain and Northern Ireland. FAU - Pereira, Stephen AU - Pereira S AD - University College London - UCL Institute of Hepatology, London, London, United Kingdom of Great Britain and Northern Ireland. AD - University College Hospitals NHS Foundation Trust - Department of Gastroenterology, London, London, United Kingdom of Great Britain and Northern Ireland. FAU - Johnson, Gavin AU - Johnson G AD - University College Hospitals NHS Foundation Trust - Department of Gastroenterology, London, London, United Kingdom of Great Britain and Northern Ireland. FAU - Oppong, Kofi AU - Oppong K AD - Freeman Hospital - HPB Unit, Newcastle upon Tyne, Newcastle upon Tyne, United Kingdom of Great Britain and Northern Ireland. FAU - Nayar, Manu AU - Nayar M AD - Freeman Hospital - HPB Unit, Newcastle upon Tyne, Newcastle upon Tyne, United Kingdom of Great Britain and Northern Ireland. FAU - Leeds, John AU - Leeds J AD - Freeman Hospital - HPB Unit, Newcastle upon Tyne, Newcastle upon Tyne, United Kingdom of Great Britain and Northern Ireland. FAU - Paranandi, Bharat AU - Paranandi B AD - Leeds Teaching Hospitals NHS Trust - Gastroenterology, Leeds, Leeds, United Kingdom of Great Britain and Northern Ireland. FAU - Penman, Ian AU - Penman I AD - Royal Infirmary of Edinburgh- Gastroenterology, Edinburgh, Edinburgh, United Kingdom of Great Britain and Northern Ireland. FAU - Carroll, Nicholas AU - Carroll N AD - Cambridge University Hospitals NHS Foundation Trust - Radiology, Cambridge, Cambridgeshire, United Kingdom of Great Britain and Northern Ireland. FAU - Godfrey, Edmund AU - Godfrey E AD - Cambridge University Hospitals NHS Foundation Trust - Radiology, Cambridge, Cambridgeshire, United Kingdom of Great Britain and Northern Ireland. FAU - James, Martin AU - James M AD - Nottingham University Hospitals NHS Trust And University Of Nottingham - Nottingham Biomedical Research Centre and NIHR Nottingham Biomedical Research Centre, Nottingham, United Kingdom of Great Britain and Northern Ireland. FAU - Aithal, Guruprasad AU - Aithal G AD - Nottingham University Hospitals NHS Trust And University Of Nottingham - Nottingham Biomedical Research Centre and NIHR Nottingham Biomedical Research Centre, Nottingham, United Kingdom of Great Britain and Northern Ireland. FAU - McKay, Colin AU - McKay C AD - Glasgow Royal Infirmary - Pancreatic Surgery, Glasgow, Glasgow, United Kingdom of Great Britain and Northern Ireland. FAU - Devlin, John AU - Devlin J AD - King's College Hospital NHS Foundation Trust - Hepatology, London, London, United Kingdom of Great Britain and Northern Ireland. FAU - Wong, Terry AU - Wong T AD - Guys and St Thomas' NHS Foundation Trust - Gastroenterology, London, United Kingdom of Great Britain and Northern Ireland. FAU - Makin, Alistair AU - Makin A AD - Central Manchester University Hospitals NHS Foundation Trust - Gastroenterology, Manchester, Greater Manchester, United Kingdom of Great Britain and Northern Ireland. FAU - Ryan, Barbara AU - Ryan B AD - Tallaght Hospital/Trinity College Dublin - Gastroenterology, Dublin, Ireland. FAU - Huggett, Matthew AU - Huggett M AD - Leeds Teaching Hospitals NHS Trust - Gastroenterology, Leeds, Leeds, United Kingdom of Great Britain and Northern Ireland. LA - eng GR - MR/N005953/1/MRC_/Medical Research Council/United Kingdom PT - Journal Article DEP - 20180228 PL - Germany TA - Endosc Int Open JT - Endoscopy international open JID - 101639919 PMC - PMC5829997 COIS- Competing interests None EDAT- 2018/03/03 06:00 MHDA- 2018/03/03 06:01 PMCR- 2018/03/01 CRDT- 2018/03/03 06:00 PHST- 2017/08/23 00:00 [received] PHST- 2017/11/22 00:00 [accepted] PHST- 2018/03/03 06:00 [entrez] PHST- 2018/03/03 06:00 [pubmed] PHST- 2018/03/03 06:01 [medline] PHST- 2018/03/01 00:00 [pmc-release] AID - 10.1055/s-0043-125362 [doi] PST - ppublish SO - Endosc Int Open. 2018 Mar;6(3):E259-E265. doi: 10.1055/s-0043-125362. Epub 2018 Feb 28.