PMID- 29498254
OWN - NLM
STAT- MEDLINE
DCOM- 20190715
LR  - 20190715
IS  - 1827-1928 (Electronic)
IS  - 0022-4707 (Linking)
VI  - 59
IP  - 2
DP  - 2019 Feb
TI  - Type 2 diabetes mellitus risk and exercise: is resistin involved?
PG  - 290-297
LID - 10.23736/S0022-4707.18.08258-0 [doi]
AB  - Obesity and associated disorders such as type 2 diabetes mellitus (T2DM) pose an 
      increasing risk to the health of both individuals and society. Adipose tissue is 
      an active endocrine organ, secreting many hormones, known as adipokines. Evidence 
      suggests that one suggest adipokine, resistin, may be elevated in the plasma of 
      individuals with T2DM, and early reports indicated that this may contribute to 
      the impaired glucose tolerance and insulin resistance observed in T2DM, hence its 
      name, resistin, however subsequent evidence suggests it may have a 
      proinflammatory role. Performing regular exercise and dietary interventions 
      improve insulin sensitivity and glucose tolerance in the majority of individuals 
      with T2DM, and we hypothesized that plasma resistin levels may drop in 
      individuals following a long term aerobic and/or resistance exercise intervention 
      program. Articles analyzing the effects of exercise on serum resistin levels were 
      therefore analyzed. Articles were selected and analyzed based on a minimum 
      aerobic and/or resistance training program of 2 sessions per week for 12 weeks. 
      Plasma resistin levels decreased following either endurance aerobic exercise 
      and/or resistance training plans in individuals with obesity and/or insulin 
      resistance, although this was not related to BMI change. Exercise intervention 
      programs generally showed potentially beneficial changes in plasma resistin 
      concentrations. It is possible these effects are mediated through 
      exercise-induced decreases in inflammation via anti-inflammatory cytokine release 
      rather than alterations in glucose metabolism and reductions in BMI per se. A 
      possible link between resistin, exercise and T2DM is discussed.
FAU - Cobbold, Christian
AU  - Cobbold C
AD  - School of Medicine, Griffith University, Sunshine Coast, Birtinya, Australia - 
      christian.cobbold@griffith.edu.au.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20180301
PL  - Italy
TA  - J Sports Med Phys Fitness
JT  - The Journal of sports medicine and physical fitness
JID - 0376337
RN  - 0 (RETN protein, human)
RN  - 0 (Resistin)
SB  - IM
MH  - Diabetes Mellitus, Type 2/*blood
MH  - Exercise/*physiology
MH  - Female
MH  - Humans
MH  - Male
MH  - Resistance Training/statistics & numerical data
MH  - Resistin/*blood
EDAT- 2018/03/03 06:00
MHDA- 2019/07/16 06:00
CRDT- 2018/03/03 06:00
PHST- 2018/03/03 06:00 [pubmed]
PHST- 2019/07/16 06:00 [medline]
PHST- 2018/03/03 06:00 [entrez]
AID - S0022-4707.18.08258-0 [pii]
AID - 10.23736/S0022-4707.18.08258-0 [doi]
PST - ppublish
SO  - J Sports Med Phys Fitness. 2019 Feb;59(2):290-297. doi: 
      10.23736/S0022-4707.18.08258-0. Epub 2018 Mar 1.