PMID- 29498492
OWN - NLM
STAT- MEDLINE
DCOM- 20180504
LR  - 20191210
IS  - 1332-8166 (Electronic)
IS  - 0353-9504 (Print)
IS  - 0353-9504 (Linking)
VI  - 59
IP  - 1
DP  - 2018 Feb 28
TI  - Disease characteristics and causes of early and late death in a group of Croatian 
      patients with systemic lupus erythematosus deceased over a 10-year period.
PG  - 3-12
AB  - AIM: To assess the causes of early death (ED) and late death (LD) in patients 
      with systemic lupus erythematosus (SLE) and determine the features of deceased 
      SLE patients followed-up in a single Croatian tertiary hospital center, because 
      little if any data on causes of death (CODs) in SLE patients are available for 
      Croatia. METHOD: We identified SLE patients regularly followed-up at the Division 
      of Clinical Immunology and Rheumatology, University Hospital Center Zagreb, who 
      died from 2002 to 2011. Death was ascertained by matching our institutional 
      records with the Croatian National Death Database. Patients were grouped 
      according to their disease duration to ED and LD and compared by demographic 
      characteristics, classification criteria, organ damage, and CODs. RESULTS: We 
      identified 90 patients (68 women), who died at the age of 58+/-15 years. The most 
      frequent COD category was cardiovascular diseases (40%), followed by infections 
      (33%), active SLE (29%), and malignancies (17%). No significant difference was 
      found between the frequencies of causes of ED and LD, except for stroke, which 
      caused only LD>/=10 years after the diagnosis. SLE was reported in death 
      certificates of only 41 of 90 patients. CONCLUSION: Although stroke occurred both 
      in the early and late disease course, it was primarily associated with LD. Given 
      the low proportion of SLE recorded in death certificates of deceased SLE 
      patients, matching of institutional and vital statistics records may be required 
      to assess the true impact of SLE on mortality.
FAU - Padjen, Ivan
AU  - Padjen I
AD  - Ivan Padjen, Division of Clinical Immunology and Rheumatology, Department of 
      Internal Medicine, University Hospital Center Zagreb and University of Zagreb 
      School of Medicine, Kispaticeva 12, 10000 Zagreb, Croatia, ivan_padjen@yahoo.ca.
FAU - Cerovec, Mislav
AU  - Cerovec M
FAU - Erceg, Marijan
AU  - Erceg M
FAU - Mayer, Miroslav
AU  - Mayer M
FAU - Stevanovic, Ranko
AU  - Stevanovic R
FAU - Anic, Branimir
AU  - Anic B
LA  - eng
PT  - Journal Article
PL  - Croatia
TA  - Croat Med J
JT  - Croatian medical journal
JID - 9424324
SB  - IM
MH  - Adult
MH  - Aged
MH  - Cardiovascular Diseases/epidemiology
MH  - *Cause of Death
MH  - Croatia/epidemiology
MH  - Death Certificates
MH  - Disease Progression
MH  - Female
MH  - Humans
MH  - Infections/epidemiology
MH  - Lupus Erythematosus, Systemic/*mortality
MH  - Male
MH  - Middle Aged
PMC - PMC5833101
EDAT- 2018/03/03 06:00
MHDA- 2018/05/05 06:00
PMCR- 2018/02/01
CRDT- 2018/03/03 06:00
PHST- 2018/03/03 06:00 [entrez]
PHST- 2018/03/03 06:00 [pubmed]
PHST- 2018/05/05 06:00 [medline]
PHST- 2018/02/01 00:00 [pmc-release]
AID - CroatMedJ_59_0003 [pii]
AID - 10.3325/cmj.2018.59.3 [doi]
PST - ppublish
SO  - Croat Med J. 2018 Feb 28;59(1):3-12. doi: 10.3325/cmj.2018.59.3.