PMID- 29498691
OWN - NLM
STAT- MEDLINE
DCOM- 20180904
LR  - 20220408
IS  - 2072-6643 (Electronic)
IS  - 2072-6643 (Linking)
VI  - 10
IP  - 3
DP  - 2018 Mar 2
TI  - Regulation of Muscle Glycogen Metabolism during Exercise: Implications for 
      Endurance Performance and Training Adaptations.
LID - 10.3390/nu10030298 [doi]
LID - 298
AB  - Since the introduction of the muscle biopsy technique in the late 1960s, our 
      understanding of the regulation of muscle glycogen storage and metabolism has 
      advanced considerably. Muscle glycogenolysis and rates of carbohydrate (CHO) 
      oxidation are affected by factors such as exercise intensity, duration, training 
      status and substrate availability. Such changes to the global exercise stimulus 
      exert regulatory effects on key enzymes and transport proteins via both hormonal 
      control and local allosteric regulation. Given the well-documented effects of 
      high CHO availability on promoting exercise performance, elite endurance athletes 
      are typically advised to ensure high CHO availability before, during and after 
      high-intensity training sessions or competition. Nonetheless, in recognition that 
      the glycogen granule is more than a simple fuel store, it is now also accepted 
      that glycogen is a potent regulator of the molecular cell signaling pathways that 
      regulate the oxidative phenotype. Accordingly, the concept of deliberately 
      training with low CHO availability has now gained increased popularity amongst 
      athletic circles. In this review, we present an overview of the regulatory 
      control of CHO metabolism during exercise (with a specific emphasis on muscle 
      glycogen utilization) in order to discuss the effects of both high and low CHO 
      availability on modulating exercise performance and training adaptations, 
      respectively.
FAU - Hearris, Mark A
AU  - Hearris MA
AD  - Research Institute for Sport & Exercise Sciences, Liverpool John Moores 
      University, Liverpool L3 3AF, UK. M.Hearris@2014.ljmu.ac.uk.
FAU - Hammond, Kelly M
AU  - Hammond KM
AD  - Research Institute for Sport & Exercise Sciences, Liverpool John Moores 
      University, Liverpool L3 3AF, UK. K.M.Hammond@2009.ljmu.ac.uk.
FAU - Fell, J Marc
AU  - Fell JM
AD  - Research Institute for Sport & Exercise Sciences, Liverpool John Moores 
      University, Liverpool L3 3AF, UK. J.M.Fell@2015.ljmu.ac.uk.
FAU - Morton, James P
AU  - Morton JP
AD  - Research Institute for Sport & Exercise Sciences, Liverpool John Moores 
      University, Liverpool L3 3AF, UK. J.P.Morton@ljmu.ac.uk.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20180302
PL  - Switzerland
TA  - Nutrients
JT  - Nutrients
JID - 101521595
RN  - 0 (Dietary Carbohydrates)
RN  - 9005-79-2 (Glycogen)
SB  - IM
MH  - Adaptation, Physiological
MH  - Animals
MH  - *Diet, Carbohydrate-Restricted
MH  - Dietary Carbohydrates/*metabolism
MH  - *Energy Metabolism
MH  - Glycogen/*metabolism
MH  - Humans
MH  - *Muscle Contraction
MH  - Muscle, Skeletal/*metabolism
MH  - Oxidation-Reduction
MH  - Phenotype
MH  - *Physical Endurance
MH  - Signal Transduction
PMC - PMC5872716
OTO - NOTNLM
OT  - athletes
OT  - glucose
OT  - muscle glycogen
OT  - train-low
COIS- The authors declare no conflict of interest.
EDAT- 2018/03/03 06:00
MHDA- 2018/09/05 06:00
PMCR- 2018/03/01
CRDT- 2018/03/03 06:00
PHST- 2018/01/09 00:00 [received]
PHST- 2018/02/23 00:00 [revised]
PHST- 2018/02/27 00:00 [accepted]
PHST- 2018/03/03 06:00 [entrez]
PHST- 2018/03/03 06:00 [pubmed]
PHST- 2018/09/05 06:00 [medline]
PHST- 2018/03/01 00:00 [pmc-release]
AID - nu10030298 [pii]
AID - nutrients-10-00298 [pii]
AID - 10.3390/nu10030298 [doi]
PST - epublish
SO  - Nutrients. 2018 Mar 2;10(3):298. doi: 10.3390/nu10030298.