PMID- 29499077
OWN - NLM
STAT- MEDLINE
DCOM- 20190812
LR  - 20190812
IS  - 1399-0012 (Electronic)
IS  - 0902-0063 (Linking)
VI  - 32
IP  - 4
DP  - 2018 Apr
TI  - Human leukocyte antigen compatibility and lymphocyte cross-matching play no 
      significant role in the current adult-to-adult living donor liver 
      transplantation.
PG  - e13234
LID - 10.1111/ctr.13234 [doi]
AB  - BACKGROUND: The impact of human leukocyte antigen (HLA) compatibility and 
      positive lymphocyte cross-match (LCM) on organ transplantation is well-recognized 
      particularly in kidney and heart transplantation; however, it is still debatable 
      in liver transplantation (LT). So, the aim of this study was to evaluate the 
      impact of HLA mismatch and positive LCM on the outcome of LT. METHODS: We 
      retrospectively analyzed the data of all adult recipients who underwent living 
      donor LT at our institute between January 2010 and July 2016. We excluded all ABO 
      blood group incompatible LDLT patients and patients with incomplete data 
      regarding HLA genotyping (n = 134). The type and degree of HLA-A, HLA-B, HLA-C, 
      HLA-DR, HLA-DQ mismatch and LCM were assessed in each donor-recipient pair and 
      their relationship to the occurrence of rejection, CMV infection and graft 
      survival was evaluated. RESULTS: A higher percentage (>50%) of donor-recipient 
      pairs had 1 HLA mismatch at each locus in the host-vs-graft direction and 
      seventeen recipients (13%) had positive LCM. Human leukocyte antigen mismatch and 
      positive LCM were not correlated with increased incidence of acute rejection 
      (P = .37, P = .6, respectively), CMV infection post-transplant (P = .52, P = .76, 
      respectively), or graft failure (HR 1.22, P = .68 and HR 1.73, P = .34, 
      respectively). CONCLUSION: Positive LCM and HLA mismatches did not affect the 
      overall graft survival after adult-to-adult LDLT and should not be considered as 
      contraindications for liver transplantation.
CI  - (c) 2018 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.
FAU - Badawy, Amr
AU  - Badawy A
AUID- ORCID: 0000-0001-9298-792X
AD  - Hepato-Biliary-Pancreatic Surgery and Transplantation department, Kyoto 
      University, Kyoto, Japan.
AD  - General Surgery department, Alexandria University, Alexandria, Egypt.
FAU - Kaido, Toshimi
AU  - Kaido T
AD  - Hepato-Biliary-Pancreatic Surgery and Transplantation department, Kyoto 
      University, Kyoto, Japan.
FAU - Yoshizawa, Atsushi
AU  - Yoshizawa A
AD  - Hepato-Biliary-Pancreatic Surgery and Transplantation department, Kyoto 
      University, Kyoto, Japan.
FAU - Yagi, Shintaro
AU  - Yagi S
AD  - Hepato-Biliary-Pancreatic Surgery and Transplantation department, Kyoto 
      University, Kyoto, Japan.
FAU - Fukumitsu, Ken
AU  - Fukumitsu K
AD  - Hepato-Biliary-Pancreatic Surgery and Transplantation department, Kyoto 
      University, Kyoto, Japan.
FAU - Okajima, Hideaki
AU  - Okajima H
AD  - Hepato-Biliary-Pancreatic Surgery and Transplantation department, Kyoto 
      University, Kyoto, Japan.
FAU - Uemoto, Shinji
AU  - Uemoto S
AD  - Hepato-Biliary-Pancreatic Surgery and Transplantation department, Kyoto 
      University, Kyoto, Japan.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20180330
PL  - Denmark
TA  - Clin Transplant
JT  - Clinical transplantation
JID - 8710240
RN  - 0 (HLA Antigens)
MH  - Adult
MH  - Female
MH  - Follow-Up Studies
MH  - Graft Rejection/epidemiology/*immunology
MH  - Graft Survival/*immunology
MH  - HLA Antigens/*immunology
MH  - Histocompatibility Testing/*methods
MH  - Humans
MH  - Incidence
MH  - Japan/epidemiology
MH  - *Liver Transplantation
MH  - Living Donors
MH  - Lymphocytes/*immunology
MH  - Male
MH  - Middle Aged
MH  - Prognosis
MH  - Risk Factors
OTO - NOTNLM
OT  - *human leukocyte antigen compatibility
OT  - *liver transplantation
OT  - *lymphocyte cross-match
OT  - *outcome
EDAT- 2018/03/03 06:00
MHDA- 2019/08/14 06:00
CRDT- 2018/03/03 06:00
PHST- 2018/02/25 00:00 [accepted]
PHST- 2018/03/03 06:00 [pubmed]
PHST- 2019/08/14 06:00 [medline]
PHST- 2018/03/03 06:00 [entrez]
AID - 10.1111/ctr.13234 [doi]
PST - ppublish
SO  - Clin Transplant. 2018 Apr;32(4):e13234. doi: 10.1111/ctr.13234. Epub 2018 Mar 30.