PMID- 29499216
OWN - NLM
STAT- MEDLINE
DCOM- 20190327
LR  - 20190327
IS  - 1872-9711 (Electronic)
IS  - 0161-813X (Linking)
VI  - 65
DP  - 2018 Mar
TI  - Brain derived neurotrophic factor (BDNF), its tyrosine kinase receptor B (TrkB) 
      and nicotine.
PG  - 186-195
LID - S0161-813X(18)30055-X [pii]
LID - 10.1016/j.neuro.2018.02.014 [doi]
AB  - Nicotine is the major neurotoxicant in cigarettes that affects many transmitter 
      systems within the brain as well as other factors, including the growth factors. 
      Brain derived neurotrophic factor (BDNF), is the most abundant growth factor in 
      the brain and plays a critical role in early new neuron differentiation, 
      development and synapsis growth, and the survival of fully developed neurons and 
      synaptic activity. Over the past 3 decades, data has emerged on the effects of 
      nicotine and cigarette smoke exposure on the expression of BDNF and its primary 
      specific receptor tyrosine kinase receptor B (TrkB). This review summarizes data 
      regarding the changes in brain BDNF expression after nicotine or cigarette smoke 
      exposure, and discusses their implications considering BDNF's functional roles.
CI  - Copyright (c) 2018 Elsevier B.V. All rights reserved.
FAU - Machaalani, Rita
AU  - Machaalani R
AD  - SIDS and Sleep Apnea Laboratory, Sydney Medical School, Medical Foundation 
      Building K25, University of Sydney, NSW 2006, Australia. Electronic address: 
      rita.machaalani@sydney.edu.au.
FAU - Chen, Hui
AU  - Chen H
AD  - School of Life Sciences, Faculty of Science, University of Technology Sydney, 
      Broadway, NSW 2007, Australia.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20180302
PL  - Netherlands
TA  - Neurotoxicology
JT  - Neurotoxicology
JID - 7905589
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Tobacco Smoke Pollution)
RN  - 6M3C89ZY6R (Nicotine)
RN  - EC 2.7.10.1 (Receptor, trkB)
SB  - IM
MH  - Animals
MH  - Brain/*drug effects/metabolism
MH  - Brain-Derived Neurotrophic Factor/*metabolism
MH  - Humans
MH  - Nicotine/*toxicity
MH  - Receptor, trkB/*metabolism
MH  - Tobacco Smoke Pollution/*adverse effects
OTO - NOTNLM
OT  - Animal models
OT  - Cigarette smoke exposure
OT  - Infant
OT  - NTRK2
OT  - Neurotrophic factor
OT  - Nicotine
EDAT- 2018/03/03 06:00
MHDA- 2019/03/28 06:00
CRDT- 2018/03/03 06:00
PHST- 2018/01/15 00:00 [received]
PHST- 2018/02/21 00:00 [revised]
PHST- 2018/02/25 00:00 [accepted]
PHST- 2018/03/03 06:00 [pubmed]
PHST- 2019/03/28 06:00 [medline]
PHST- 2018/03/03 06:00 [entrez]
AID - S0161-813X(18)30055-X [pii]
AID - 10.1016/j.neuro.2018.02.014 [doi]
PST - ppublish
SO  - Neurotoxicology. 2018 Mar;65:186-195. doi: 10.1016/j.neuro.2018.02.014. Epub 2018 
      Mar 2.