PMID- 29499226
OWN - NLM
STAT- MEDLINE
DCOM- 20180918
LR  - 20231213
IS  - 1879-1166 (Electronic)
IS  - 0198-8859 (Linking)
VI  - 79
IP  - 6
DP  - 2018 Jun
TI  - Clinicopathologic significance of HLA-G and HLA-E molecules in Tunisian patients 
      with ovarian carcinoma.
PG  - 463-470
LID - S0198-8859(18)30050-8 [pii]
LID - 10.1016/j.humimm.2018.02.012 [doi]
AB  - BACKGROUND: The human leukocyte antigen (HLA)-G and HLA-E, non classical HLA 
      class I molecules, have been highly implicated in immune tolerance. HLA-G and 
      HLA-E molecules were proposed as putative markers of several advanced cancers. As 
      a step towards a better understanding of ovarian carcinoma, we evaluated the 
      expression of both HLA-G and HLA-E molecules and explored their prognostic 
      implication. METHODS: HLA-G and HLA-E expression were studied by 
      immunohistochemistry on ovarian carcinoma tissues. This expression was 
      semi-quantitatively scored into four expression groups and correlated to 
      clinicopathological parameters and patients' survival. RESULTS: HLA-G and HLA-E 
      have been found to be highly expressed in ovarian carcinoma tissues 
      (Respectively, 72.4% and 96.8%). They are frequently co-expressed. Univariate and 
      multivariate analysis revealed that a positive HLA-G expression status in tumor 
      tissue is a promising candidate parameter to predict disease recurrence in 
      addition to the disease status in Tunisian patients with ovarian carcinoma. 
      Moreover, the elevated HLA-E expression was associated with serous ovarian 
      carcinoma subtype as well as with advanced stages of ovarian carcinoma. 
      CONCLUSION: HLA-G and HLA-E are highly represented in ovarian carcinoma 
      suggesting a potential association with progressive disease mechanism. HLA-G and 
      HLA-E molecules might be new candidates' markers for ovarian carcinoma 
      progression.
CI  - Copyright (c) 2018 American Society for Histocompatibility and Immunogenetics. 
      Published by Elsevier Inc. All rights reserved.
FAU - Babay, Wafa
AU  - Babay W
AD  - Laboratory Microorganisms and Active Biomolecules, Sciences Faculty of Tunis, 
      University of Tunis El Manar, Tunis, Tunisia.
FAU - Ben Yahia, Hamza
AU  - Ben Yahia H
AD  - Laboratory Microorganisms and Active Biomolecules, Sciences Faculty of Tunis, 
      University of Tunis El Manar, Tunis, Tunisia.
FAU - Boujelbene, Nadia
AU  - Boujelbene N
AD  - Laboratory Microorganisms and Active Biomolecules, Sciences Faculty of Tunis, 
      University of Tunis El Manar, Tunis, Tunisia; Department of Pathology, Salah 
      Azaiz Institute, Tunis, Tunisia.
FAU - Zidi, Nour
AU  - Zidi N
AD  - Department of Radiotherapy, Salah Azaiz Institute, Tunis, Tunisia.
FAU - Laaribi, Ahmed Baligh
AU  - Laaribi AB
AD  - Laboratory Microorganisms and Active Biomolecules, Sciences Faculty of Tunis, 
      University of Tunis El Manar, Tunis, Tunisia.
FAU - Kacem, Dhikra
AU  - Kacem D
AD  - Department of Pathology, Salah Azaiz Institute, Tunis, Tunisia.
FAU - Ben Ghorbel, Radhia
AU  - Ben Ghorbel R
AD  - Department of Pathology, Salah Azaiz Institute, Tunis, Tunisia.
FAU - Boudabous, Abdellatif
AU  - Boudabous A
AD  - Laboratory Microorganisms and Active Biomolecules, Sciences Faculty of Tunis, 
      University of Tunis El Manar, Tunis, Tunisia.
FAU - Ouzari, Hadda-Imene
AU  - Ouzari HI
AD  - Laboratory Microorganisms and Active Biomolecules, Sciences Faculty of Tunis, 
      University of Tunis El Manar, Tunis, Tunisia.
FAU - Rizzo, Roberta
AU  - Rizzo R
AD  - Department of Experimental and Diagnostic Medicine, Section Microbiology, 
      University of Ferrara, Ferrara, Italy.
FAU - Rebmann, Vera
AU  - Rebmann V
AD  - Institute for Transfusion Medicine, University Hospital Essen, Virchowstr. 179, 
      45147 Essen, Germany.
FAU - Mrad, Karima
AU  - Mrad K
AD  - Laboratory Microorganisms and Active Biomolecules, Sciences Faculty of Tunis, 
      University of Tunis El Manar, Tunis, Tunisia; Department of Pathology, Salah 
      Azaiz Institute, Tunis, Tunisia.
FAU - Zidi, Ines
AU  - Zidi I
AD  - Laboratory Microorganisms and Active Biomolecules, Sciences Faculty of Tunis, 
      University of Tunis El Manar, Tunis, Tunisia. Electronic address: 
      ines.zidi@istmt.utm.tn.
LA  - eng
PT  - Journal Article
DEP - 20180302
PL  - United States
TA  - Hum Immunol
JT  - Human immunology
JID - 8010936
RN  - 0 (Biomarkers, Tumor)
RN  - 0 (HLA-G Antigens)
RN  - 0 (Histocompatibility Antigens Class I)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Biomarkers, Tumor/metabolism
MH  - Carcinogenesis
MH  - Carcinoma, Ovarian Epithelial
MH  - Female
MH  - HLA-G Antigens/*metabolism
MH  - Histocompatibility Antigens Class I/*metabolism
MH  - Humans
MH  - Immunohistochemistry
MH  - Middle Aged
MH  - Neoplasm Metastasis
MH  - Neoplasm Staging
MH  - Neoplasms, Glandular and Epithelial/*immunology/pathology
MH  - Ovarian Neoplasms/*immunology/pathology
MH  - Tunisia
MH  - HLA-E Antigens
OTO - NOTNLM
OT  - HLA-E
OT  - HLA-G
OT  - Ovarian carcinoma
EDAT- 2018/03/03 06:00
MHDA- 2018/09/19 06:00
CRDT- 2018/03/03 06:00
PHST- 2017/08/14 00:00 [received]
PHST- 2018/02/22 00:00 [revised]
PHST- 2018/02/22 00:00 [accepted]
PHST- 2018/03/03 06:00 [pubmed]
PHST- 2018/09/19 06:00 [medline]
PHST- 2018/03/03 06:00 [entrez]
AID - S0198-8859(18)30050-8 [pii]
AID - 10.1016/j.humimm.2018.02.012 [doi]
PST - ppublish
SO  - Hum Immunol. 2018 Jun;79(6):463-470. doi: 10.1016/j.humimm.2018.02.012. Epub 2018 
      Mar 2.