PMID- 29499288
OWN - NLM
STAT- MEDLINE
DCOM- 20191106
LR  - 20191106
IS  - 1522-9653 (Electronic)
IS  - 1063-4584 (Linking)
VI  - 26
IP  - 5
DP  - 2018 May
TI  - NLRP3 as a potentially novel biomarker for the management of osteoarthritis.
PG  - 612-619
LID - S1063-4584(18)31060-4 [pii]
LID - 10.1016/j.joca.2018.02.901 [doi]
AB  - Osteoarthritis (OA) was previously thought of as 'wear and tear' as humans age, 
      however there is increasing evidence to support an inflammatory theory. The 
      nucleotide-binding and oligomerization domain-like receptor containing protein 3 
      (NLRP3) inflammasome has been implicated in the pathogenesis of a number of 
      arthritic disorders, producing proinflammatory cytokines and degradative enzymes 
      such as Interleukin-1 beta (IL-1beta), Tumour necrosis factor alpha (TNF-alpha) and 
      Matrix metalloproteinase-3 (MMP-3) which drive cartilage degeneration and 
      synovial inflammation. This review aims to summarise the evidence of NLRP3 
      involvement in OA. Currently, treatment options focus on management of the 
      disease and to date there is no cure. The development of novel biomarkers for OA 
      could improve diagnosis, treatment and management. Importantly, this review 
      provides detail on the involvement of the NLRP3 inflammasome in OA pathology and 
      how its members could act as potential biomarkers to assist clinical decisions.
CI  - Copyright (c) 2018 Osteoarthritis Research Society International. Published by 
      Elsevier Ltd. All rights reserved.
FAU - McAllister, M J
AU  - McAllister MJ
AD  - Northern Ireland Centre for Stratified Medicine, Ulster University, Altnagelvin 
      Hospital, Glenshane Road, Londonderry, United Kingdom. Electronic address: 
      mcallister-m16@email.ulster.ac.uk.
FAU - Chemaly, M
AU  - Chemaly M
AD  - Northern Ireland Centre for Stratified Medicine, Ulster University, Altnagelvin 
      Hospital, Glenshane Road, Londonderry, United Kingdom.
FAU - Eakin, A J
AU  - Eakin AJ
AD  - Northern Ireland Centre for Stratified Medicine, Ulster University, Altnagelvin 
      Hospital, Glenshane Road, Londonderry, United Kingdom.
FAU - Gibson, D S
AU  - Gibson DS
AD  - Northern Ireland Centre for Stratified Medicine, Ulster University, Altnagelvin 
      Hospital, Glenshane Road, Londonderry, United Kingdom. Electronic address: 
      d.gibson@ulster.ac.uk.
FAU - McGilligan, V E
AU  - McGilligan VE
AD  - Northern Ireland Centre for Stratified Medicine, Ulster University, Altnagelvin 
      Hospital, Glenshane Road, Londonderry, United Kingdom.
LA  - eng
GR  - 206952/Z/17/Z/WT_/Wellcome Trust/United Kingdom
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20180302
PL  - England
TA  - Osteoarthritis Cartilage
JT  - Osteoarthritis and cartilage
JID - 9305697
RN  - 0 (Biomarkers)
RN  - 0 (NLR Family, Pyrin Domain-Containing 3 Protein)
RN  - 0 (NLRP3 protein, human)
SB  - IM
MH  - Biomarkers/metabolism
MH  - *Disease Management
MH  - Humans
MH  - NLR Family, Pyrin Domain-Containing 3 Protein/*metabolism
MH  - Osteoarthritis/diagnosis/*metabolism/therapy
OTO - NOTNLM
OT  - Biomarker
OT  - Inflammasome
OT  - Inflammation
OT  - NLRP3
OT  - Osteoarthritis
EDAT- 2018/03/03 06:00
MHDA- 2019/11/07 06:00
CRDT- 2018/03/03 06:00
PHST- 2017/07/17 00:00 [received]
PHST- 2018/02/09 00:00 [revised]
PHST- 2018/02/20 00:00 [accepted]
PHST- 2018/03/03 06:00 [pubmed]
PHST- 2019/11/07 06:00 [medline]
PHST- 2018/03/03 06:00 [entrez]
AID - S1063-4584(18)31060-4 [pii]
AID - 10.1016/j.joca.2018.02.901 [doi]
PST - ppublish
SO  - Osteoarthritis Cartilage. 2018 May;26(5):612-619. doi: 
      10.1016/j.joca.2018.02.901. Epub 2018 Mar 2.