PMID- 29499519
OWN - NLM
STAT- MEDLINE
DCOM- 20180724
LR  - 20181202
IS  - 1879-1298 (Electronic)
IS  - 0045-6535 (Linking)
VI  - 200
DP  - 2018 Jun
TI  - The challenging use and interpretation of circulating biomarkers of exposure to 
      persistent organic pollutants in environmental health: Comparison of lipid 
      adjustment approaches in a case study related to endometriosis.
PG  - 388-396
LID - S0045-6535(18)30332-1 [pii]
LID - 10.1016/j.chemosphere.2018.02.120 [doi]
AB  - The gold-standard matrix for measuring the internal levels of persistent organic 
      pollutants (POPs) is the adipose tissue, however in epidemiological studies the 
      use of serum is preferred due to the low cost and higher accessibility. The 
      interpretation of serum biomarkers is tightly related to the understanding of the 
      underlying causal structure relating the POPs, serum lipids and the disease. 
      Considering the extended benefits of using serum biomarkers we aimed to further 
      examine if through statistical modelling we would be able to improve the use and 
      interpretation of serum biomarkers in the study of endometriosis. Hence, we have 
      conducted a systematic comparison of statistical approaches commonly used to 
      lipid-adjust the circulating biomarkers of POPs based on existing methods, using 
      data from a pilot case-control study focused on severe deep infiltrating 
      endometriosis. The odds ratios (ORs) obtained from unconditional regression for 
      those models with serum biomarkers were further compared to those obtained from 
      adipose tissue. The results of this exploratory study did not support the use of 
      blood biomarkers as proxy estimates of POPs in adipose tissue to implement in 
      risk models for endometriosis with the available statistical approaches to 
      correct for lipids. The current statistical approaches commonly used to 
      lipid-adjust circulating POPs, do not fully represent the underlying biological 
      complexity between POPs, lipids and disease (especially those directly or 
      indirectly affecting or affected by lipid metabolism). Hence, further 
      investigations are warranted to improve the use and interpretation of blood 
      biomarkers under complex scenarios of lipid dynamics.
CI  - Copyright (c) 2018 Elsevier Ltd. All rights reserved.
FAU - Cano-Sancho, German
AU  - Cano-Sancho G
AD  - LABERCA, Oniris, INRA, Universite Bretagne-Loire, 44307, Nantes, France. 
      Electronic address: laberca@oniris-nantes.fr.
FAU - Labrune, Lea
AU  - Labrune L
AD  - LABERCA, Oniris, INRA, Universite Bretagne-Loire, 44307, Nantes, France.
FAU - Ploteau, Stephane
AU  - Ploteau S
AD  - LABERCA, Oniris, INRA, Universite Bretagne-Loire, 44307, Nantes, France; Service 
      de Gynecologie-Obstetrique, CIC FEA, Hopital Mere Enfant, CHU Hotel Dieu, Nantes, 
      France.
FAU - Marchand, Philippe
AU  - Marchand P
AD  - LABERCA, Oniris, INRA, Universite Bretagne-Loire, 44307, Nantes, France.
FAU - Le Bizec, Bruno
AU  - Le Bizec B
AD  - LABERCA, Oniris, INRA, Universite Bretagne-Loire, 44307, Nantes, France.
FAU - Antignac, Jean-Philippe
AU  - Antignac JP
AD  - LABERCA, Oniris, INRA, Universite Bretagne-Loire, 44307, Nantes, France.
LA  - eng
PT  - Journal Article
DEP - 20180221
PL  - England
TA  - Chemosphere
JT  - Chemosphere
JID - 0320657
RN  - 0 (Biomarkers)
RN  - 0 (Environmental Pollutants)
RN  - 0 (Lipids)
SB  - IM
MH  - Adipose Tissue/*metabolism
MH  - Adolescent
MH  - Adult
MH  - Biomarkers/*blood
MH  - Case-Control Studies
MH  - Endometriosis/*blood/chemically induced/*pathology
MH  - Environmental Exposure/adverse effects/*analysis
MH  - Environmental Health
MH  - Environmental Pollutants/adverse effects/*blood
MH  - Female
MH  - Humans
MH  - Lipids/*chemistry
MH  - Middle Aged
MH  - Pilot Projects
MH  - Prospective Studies
MH  - Young Adult
OTO - NOTNLM
OT  - Biomarkers
OT  - Endocrine-disrupting chemicals
OT  - Endometriosis
OT  - Lipid adjustment
OT  - Polychlorinated biphenyls
OT  - Polychlorinated dibenzodioxins
EDAT- 2018/03/03 06:00
MHDA- 2018/07/25 06:00
CRDT- 2018/03/03 06:00
PHST- 2018/01/03 00:00 [received]
PHST- 2018/02/16 00:00 [revised]
PHST- 2018/02/19 00:00 [accepted]
PHST- 2018/03/03 06:00 [pubmed]
PHST- 2018/07/25 06:00 [medline]
PHST- 2018/03/03 06:00 [entrez]
AID - S0045-6535(18)30332-1 [pii]
AID - 10.1016/j.chemosphere.2018.02.120 [doi]
PST - ppublish
SO  - Chemosphere. 2018 Jun;200:388-396. doi: 10.1016/j.chemosphere.2018.02.120. Epub 
      2018 Feb 21.