PMID- 29501197
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20180330
LR  - 20180330
IS  - 1873-3573 (Electronic)
IS  - 0039-9140 (Linking)
VI  - 182
DP  - 2018 May 15
TI  - Ammonium hydroxide enhancing electrospray response and boosting sensitivity of 
      bisphenol A and its analogs.
PG  - 590-594
LID - S0039-9140(18)30142-5 [pii]
LID - 10.1016/j.talanta.2018.02.033 [doi]
AB  - As one of the most important analytical techniques for accurate quantification of 
      bisphenol compounds, liquid chromatography coupled to online electrospray 
      ionization (ESI) tandem mass spectrometry exhibits relative weak ESI response in 
      negative mode, which greatly reduces their sensitivity and limits their detection 
      at trace levels, especially in complex samples such as blood. Based on the 
      facilitated deprotonation of bisphenol molecule under alkaline condition, 
      post-column injection of ammonium hydroxide (NH(3).H(2)O) to mass spectrometer 
      was explored to enhance the ionization efficiency of BPA and its eight analogs 
      and improve their analytical sensitivity. Parameters effecting response intensity 
      and stability were investigated, including mass concentration and flow rate of 
      NH(3).H(2)O. Under the optimal conditions with the addition of 2% (w/w) of 
      NH(3).H(2)O at 4 muL min(-1), the instrument detection limits for bisphenol 
      compounds were greatly lowered to 0.001-0.04 ng mL(-1), which were 2-28.6 times 
      lower than the result obtained without injecting NH(3).H(2)O, except TBBPA 
      (0.03 ng mL(-1) in either case). The relative standard deviations (RSDs) for 
      instrument repeatability of BPA and its analogs at three different concentration 
      levels were in a range of 1.2-20%. Furthermore, a decreased matrix effects 
      (90-111%) for bisphenols (except TBBPA) analysis in serum extracts were found 
      compared with the result obtained without NH(3).H(2)O injection (43-111%). The 
      results demonstrated that the improved instrumental method coupled with suitable 
      pretreatment techniques is more feasible to analyze bisphenol compounds in 
      complex bio-samples.
CI  - Copyright (c) 2018 Elsevier B.V. All rights reserved.
FAU - Tan, Dongqin
AU  - Tan D
AD  - CAS Key Laboratory of Separation Science for Analytical Chemistry, Dalian 
      Institute of Chemical Physics, Chinese Academy of Sciences, Dalian 116023, China; 
      University of Chinese Academy of Sciences, Beijing 100049, China.
FAU - Jin, Jing
AU  - Jin J
AD  - CAS Key Laboratory of Separation Science for Analytical Chemistry, Dalian 
      Institute of Chemical Physics, Chinese Academy of Sciences, Dalian 116023, China.
FAU - Wang, Longxing
AU  - Wang L
AD  - CAS Key Laboratory of Separation Science for Analytical Chemistry, Dalian 
      Institute of Chemical Physics, Chinese Academy of Sciences, Dalian 116023, China.
FAU - Zhao, Xueqin
AU  - Zhao X
AD  - Guangzhou women and children's medical center, Guangzhou Medical University, 
      Guangzhou 511436, China.
FAU - Guo, Cuicui
AU  - Guo C
AD  - CAS Key Laboratory of Separation Science for Analytical Chemistry, Dalian 
      Institute of Chemical Physics, Chinese Academy of Sciences, Dalian 116023, China; 
      University of Chinese Academy of Sciences, Beijing 100049, China.
FAU - Sun, Xiaoli
AU  - Sun X
AD  - Department of Chemistry, Lishui University, Lishui 32300, China.
FAU - Dhanjai
AU  - Dhanjai
AD  - CAS Key Laboratory of Separation Science for Analytical Chemistry, Dalian 
      Institute of Chemical Physics, Chinese Academy of Sciences, Dalian 116023, China.
FAU - Lu, Xianbo
AU  - Lu X
AD  - CAS Key Laboratory of Separation Science for Analytical Chemistry, Dalian 
      Institute of Chemical Physics, Chinese Academy of Sciences, Dalian 116023, China.
FAU - Chen, Jiping
AU  - Chen J
AD  - CAS Key Laboratory of Separation Science for Analytical Chemistry, Dalian 
      Institute of Chemical Physics, Chinese Academy of Sciences, Dalian 116023, China. 
      Electronic address: chenjp@dicp.ac.cn.
LA  - eng
PT  - Journal Article
DEP - 20180209
PL  - Netherlands
TA  - Talanta
JT  - Talanta
JID - 2984816R
OTO - NOTNLM
OT  - Ammonium hydroxide
OT  - Bisphenol
OT  - Electrospray ionization
OT  - Ionization efficiency
EDAT- 2018/03/05 06:00
MHDA- 2018/03/05 06:01
CRDT- 2018/03/05 06:00
PHST- 2017/10/24 00:00 [received]
PHST- 2018/02/05 00:00 [revised]
PHST- 2018/02/07 00:00 [accepted]
PHST- 2018/03/05 06:00 [entrez]
PHST- 2018/03/05 06:00 [pubmed]
PHST- 2018/03/05 06:01 [medline]
AID - S0039-9140(18)30142-5 [pii]
AID - 10.1016/j.talanta.2018.02.033 [doi]
PST - ppublish
SO  - Talanta. 2018 May 15;182:590-594. doi: 10.1016/j.talanta.2018.02.033. Epub 2018 
      Feb 9.