PMID- 29501631
OWN - NLM
STAT- MEDLINE
DCOM- 20190321
LR  - 20190321
IS  - 1872-9711 (Electronic)
IS  - 0161-813X (Linking)
VI  - 66
DP  - 2018 May
TI  - Methamphetamine binge administration during late adolescence induced enduring 
      hippocampal cell damage following prolonged withdrawal in rats.
PG  - 1-9
LID - S0161-813X(18)30057-3 [pii]
LID - 10.1016/j.neuro.2018.02.016 [doi]
AB  - A recent study from our laboratory demonstrated that binge methamphetamine 
      induced hippocampal cell damage (i.e., impaired cell genesis) in rats when 
      administered specifically during late adolescence (postnatal day, PND 54-57) and 
      evaluated 24 h later (PND 58). The results also suggested a possible role for 
      brain-derived neurotrophic factor (BDNF) regulating cell genesis and survival. 
      This subsequent study evaluated whether these effects persisted in time as 
      measured following prolonged withdrawal. Male Sprague-Dawley rats were treated 
      (i.p.) with BrdU (2 x 50 mg/kg, 3 days, PND 48-50) followed by a binge paradigm 
      (3 pulses/day, every 3 h, 4 days, PND 54-57) of methamphetamine (5 mg/kg, n = 14, 
      M) or saline (0.9% NaCl, 1 ml/kg, n = 12, C). Following 34 days of forced 
      withdrawal (PND 91), rats were killed 45 min after a challenge dose of saline 
      (Sal: C-Sal, n = 6; M-Sal, n = 7) or methamphetamine (Meth: C-Meth, n = 6; 
      M-Meth, n = 7). Neurogenesis markers (Ki-67: cell proliferation; NeuroD: early 
      neuronal survival; BrdU: prolonged cell survival, 41-43 days old cells) were 
      evaluated by immunohistochemistry while neuroplasticity markers (BDNF and Fos 
      forms) were evaluated by Western blot. The main results showed that a history of 
      methamphetamine administration (PND 54-57) induced enduring hippocampal cell 
      damage (i.e., observed on PND 91) by decreasing cell survival (BrdU + cells) and 
      mature-BDNF (m-BDNF) protein content, associated with neuronal survival, growth 
      and differentiation. Interestingly, m-BDNF regulation paralleled hippocampal 
      c-Fos protein content, indicating decreased neuronal activity, and thus 
      reinforcing the persisting negative effects induced by methamphetamine in rat 
      hippocampus following prolonged withdrawal.
CI  - Copyright (c) 2018 Elsevier B.V. All rights reserved.
FAU - Garcia-Cabrerizo, Ruben
AU  - Garcia-Cabrerizo R
AD  - IUNICS, University of the Balearic Islands, Palma, Spain; Balearic Islands Health 
      Research Institute (IdISBa), Palma, Spain.
FAU - Bis-Humbert, Cristian
AU  - Bis-Humbert C
AD  - IUNICS, University of the Balearic Islands, Palma, Spain; Balearic Islands Health 
      Research Institute (IdISBa), Palma, Spain.
FAU - Garcia-Fuster, M Julia
AU  - Garcia-Fuster MJ
AD  - IUNICS, University of the Balearic Islands, Palma, Spain; Balearic Islands Health 
      Research Institute (IdISBa), Palma, Spain. Electronic address: j.garcia@uib.es.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20180306
PL  - Netherlands
TA  - Neurotoxicology
JT  - Neurotoxicology
JID - 7905589
RN  - 0 (Bdnf protein, rat)
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 44RAL3456C (Methamphetamine)
SB  - IM
MH  - Animals
MH  - Brain-Derived Neurotrophic Factor/metabolism
MH  - Hippocampus/*drug effects/*physiology
MH  - Male
MH  - Methamphetamine/*administration & dosage
MH  - Neurogenesis/*drug effects
MH  - Neuronal Plasticity/drug effects
MH  - Neurons/drug effects/physiology
MH  - Rats, Sprague-Dawley
OTO - NOTNLM
OT  - Age
OT  - Methamphetamine
OT  - Neurogenesis
OT  - Neuroplasticity
OT  - Neurotoxicity
OT  - Withdrawal
EDAT- 2018/03/05 06:00
MHDA- 2019/03/22 06:00
CRDT- 2018/03/05 06:00
PHST- 2017/11/13 00:00 [received]
PHST- 2018/01/22 00:00 [revised]
PHST- 2018/02/26 00:00 [accepted]
PHST- 2018/03/05 06:00 [pubmed]
PHST- 2019/03/22 06:00 [medline]
PHST- 2018/03/05 06:00 [entrez]
AID - S0161-813X(18)30057-3 [pii]
AID - 10.1016/j.neuro.2018.02.016 [doi]
PST - ppublish
SO  - Neurotoxicology. 2018 May;66:1-9. doi: 10.1016/j.neuro.2018.02.016. Epub 2018 Mar 
      6.