PMID- 29501829
OWN - NLM
STAT- MEDLINE
DCOM- 20180615
LR  - 20221207
IS  - 1872-8227 (Electronic)
IS  - 0168-8227 (Linking)
VI  - 139
DP  - 2018 May
TI  - Improvements of ambient hyperglycemia and glycemic variability are associated 
      with reduction in oxidative stress for patients with type 2 diabetes.
PG  - 253-261
LID - S0168-8227(17)31645-5 [pii]
LID - 10.1016/j.diabres.2018.02.017 [doi]
AB  - AIMS: We aimed to evaluate which parameters of improvement in glucose metabolism 
      reduce oxidative stress for patients with Type 2 diabetes mellitus (T2DM). 
      METHODS: Sixty-seven outpatients with T2DM underwent 72 h of continuous glucose 
      monitoring (CGM) and were measured for oxidative stress before and after a 
      24-week intervention with the following targets: fasting plasma glucose (FPG), 
      <130 mg/dl; postprandial plasma glucose (PPG), <180 mg/dl; and glycated 
      hemoglobin (HbA1c), <7% (53 mmol/mol). The mean glucose level (MGL), mean 
      amplitude of glycemic excursions (MAGE), mean of daily differences (MODD), 
      percentage coefficient of variation for glucose (%CV) and area under the 
      postprandial plasma glucose curve (AUC(PP)) were calculated from the CGM data. 
      Oxidative stress was estimated using the diacron-reactive oxygen metabolites 
      (d-ROMs) test. Finally, the association between the improvements in glucose 
      metabolism and oxidative stress was evaluated. RESULTS: FPG, MGL, HbA1c, MAGE, 
      MODD, %CV, AUC(PP), and d-ROMs significantly improved after 24 weeks of 
      intervention. The change in d-ROMs was significantly correlated with that in FPG 
      (r = 0.414), MGL (r = 0.402), HbA1c (r = 0.271), MAGE (r = 0.457), MODD 
      (r = 0.371), and AUC(PP) (r = 0.352). The correlation of the change in d-ROMs 
      with that in FPG, MAGE, and MODD and the use of glucose-like peptide 1 receptor 
      agonists and statins remained significant after adjustment for other markers of 
      diabetes control (multiple R(2) = 0.406). CONCLUSIONS: Improvements in glucose 
      metabolism, including FPG and daily and day-to-day glucose variability, were all 
      correlated with reduced oxidative stress for patients with T2DM.
CI  - Published by Elsevier B.V.
FAU - Ohara, Makoto
AU  - Ohara M
AD  - Department of Medicine, Division of Diabetes, Metabolism, and Endocrinology, 
      Showa University School of Medicine, Tokyo, Japan. Electronic address: 
      s6018@nms.ac.jp.
FAU - Nagaike, Hiroe
AU  - Nagaike H
AD  - Department of Medicine, Division of Diabetes, Metabolism, and Endocrinology, 
      Showa University School of Medicine, Tokyo, Japan.
FAU - Goto, Satoshi
AU  - Goto S
AD  - Department of Medicine, Division of Diabetes, Metabolism, and Endocrinology, 
      Showa University School of Medicine, Tokyo, Japan.
FAU - Fukase, Ayako
AU  - Fukase A
AD  - Department of Medicine, Division of Diabetes, Metabolism, and Endocrinology, 
      Showa University School of Medicine, Tokyo, Japan.
FAU - Tanabe, Yuki
AU  - Tanabe Y
AD  - Department of Medicine, Division of Diabetes, Metabolism, and Endocrinology, 
      Showa University School of Medicine, Tokyo, Japan.
FAU - Tomoyasu, Masako
AU  - Tomoyasu M
AD  - Department of Medicine, Division of Diabetes, Metabolism, and Endocrinology, 
      Showa University School of Medicine, Tokyo, Japan.
FAU - Yamamoto, Takeshi
AU  - Yamamoto T
AD  - Department of Medicine, Division of Diabetes, Metabolism, and Endocrinology, 
      Showa University School of Medicine, Tokyo, Japan.
FAU - Hayashi, Toshiyuki
AU  - Hayashi T
AD  - Department of Medicine, Division of Diabetes, Metabolism, and Endocrinology, 
      Showa University School of Medicine, Tokyo, Japan.
FAU - Fukui, Tomoyasu
AU  - Fukui T
AD  - Department of Medicine, Division of Diabetes, Metabolism, and Endocrinology, 
      Showa University School of Medicine, Tokyo, Japan.
FAU - Hirano, Tsutomu
AU  - Hirano T
AD  - Department of Medicine, Division of Diabetes, Metabolism, and Endocrinology, 
      Showa University School of Medicine, Tokyo, Japan.
LA  - eng
PT  - Journal Article
DEP - 20180301
PL  - Ireland
TA  - Diabetes Res Clin Pract
JT  - Diabetes research and clinical practice
JID - 8508335
RN  - 0 (Blood Glucose)
RN  - 0 (Glycated Hemoglobin A)
SB  - IM
MH  - Blood Glucose/*metabolism
MH  - Diabetes Mellitus, Type 2/*blood
MH  - Female
MH  - Glycated Hemoglobin/*metabolism
MH  - Humans
MH  - Hyperglycemia/*drug therapy
MH  - Male
MH  - Middle Aged
MH  - Oxidative Stress/*drug effects
OTO - NOTNLM
OT  - Diacron-reactive oxygen metabolites
OT  - Glucose monitoring
OT  - Glucose variability
OT  - Oxidative stress
OT  - Type 2 diabetes mellitus
EDAT- 2018/03/05 06:00
MHDA- 2018/06/16 06:00
CRDT- 2018/03/05 06:00
PHST- 2017/11/01 00:00 [received]
PHST- 2018/01/31 00:00 [revised]
PHST- 2018/02/13 00:00 [accepted]
PHST- 2018/03/05 06:00 [pubmed]
PHST- 2018/06/16 06:00 [medline]
PHST- 2018/03/05 06:00 [entrez]
AID - S0168-8227(17)31645-5 [pii]
AID - 10.1016/j.diabres.2018.02.017 [doi]
PST - ppublish
SO  - Diabetes Res Clin Pract. 2018 May;139:253-261. doi: 
      10.1016/j.diabres.2018.02.017. Epub 2018 Mar 1.