PMID- 29504283
OWN - NLM
STAT- MEDLINE
DCOM- 20191021
LR  - 20191022
IS  - 2192-2659 (Electronic)
IS  - 2192-2640 (Linking)
VI  - 7
IP  - 13
DP  - 2018 Jul
TI  - Graphene Materials in Antimicrobial Nanomedicine: Current Status and Future 
      Perspectives.
PG  - e1701406
LID - 10.1002/adhm.201701406 [doi]
AB  - Graphene materials (GMs), such as graphene, graphene oxide (GO), reduced GO 
      (rGO), and graphene quantum dots (GQDs), are rapidly emerging as a new class of 
      broad-spectrum antimicrobial agents. This report describes their state-of-the-art 
      and potential future covering both fundamental aspects and biomedical 
      applications. First, the current understanding of the antimicrobial mechanisms of 
      GMs is illustrated, and the complex picture of underlying 
      structure-property-activity relationships is sketched. Next, the different modes 
      of utilization of antimicrobial GMs are explained, which include their use as 
      colloidal dispersions, surface coatings, and photothermal/photodynamic therapy 
      agents. Due to their practical relevance, the examples where GMs function as 
      synergistic agents or release platforms for metal ions and/or antibiotic drugs 
      are also discussed. Later, the applicability of GMs in the design of wound 
      dressings, infection-protective coatings, and antibiotic-like formulations 
      ("nanoantibiotics") is assessed. Notably, to support our assessments, the 
      existing clinical applications of conventional carbon materials are also 
      evaluated. Finally, the key hurdles of the field are highlighted, and several 
      possible directions for future investigations are proposed. We hope that the 
      roadmap provided here will encourage researchers to tackle remaining challenges 
      toward clinical translation of promising research findings and help realize the 
      potential of GMs in antimicrobial nanomedicine.
CI  - (c) 2018 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
FAU - Karahan, Huseyin Enis
AU  - Karahan HE
AD  - School of Chemical and Biomolecular Engineering, The University of Sydney, NSW, 
      2006, Australia.
AD  - School of Chemical and Biomedical Engineering, Nanyang Technological University, 
      Singapore, 637459, Singapore.
AD  - Singapore Institute of Manufacturing Technology, Singapore, 638075, Singapore.
FAU - Wiraja, Christian
AU  - Wiraja C
AD  - School of Chemical and Biomedical Engineering, Nanyang Technological University, 
      Singapore, 637459, Singapore.
FAU - Xu, Chenjie
AU  - Xu C
AD  - School of Chemical and Biomedical Engineering, Nanyang Technological University, 
      Singapore, 637459, Singapore.
AD  - NTU-Northwestern Institute of Nanomedicine, Nanyang Technological University, 50 
      Nanyang Avenue, Singapore, 639798, Singapore.
FAU - Wei, Jun
AU  - Wei J
AD  - Singapore Institute of Manufacturing Technology, Singapore, 638075, Singapore.
FAU - Wang, Yilei
AU  - Wang Y
AD  - School of Chemistry & Chemical Engineering, Tianjin University of Technology, 391 
      Binshui, Xidao, Xiqing District, Tianjin, 300384, China.
FAU - Wang, Liang
AU  - Wang L
AD  - School of Chemistry & Chemical Engineering, Tianjin University of Technology, 391 
      Binshui, Xidao, Xiqing District, Tianjin, 300384, China.
FAU - Liu, Fei
AU  - Liu F
AD  - State Key Laboratory of Applied Microbiology Southern China, Guangdong Provincial 
      Key, Laboratory of Microbial Culture Collection and Application, Guangdong 
      Institute of Microbiology, 100 Central Xianlie Road, Guangzhou, 510070, China.
FAU - Chen, Yuan
AU  - Chen Y
AUID- ORCID: 0000-0001-9059-3839
AD  - School of Chemical and Biomolecular Engineering, The University of Sydney, NSW, 
      2006, Australia.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20180305
PL  - Germany
TA  - Adv Healthc Mater
JT  - Advanced healthcare materials
JID - 101581613
RN  - 0 (Anti-Infective Agents)
RN  - 7782-42-5 (Graphite)
SB  - IM
MH  - Animals
MH  - Anti-Infective Agents/*chemistry/*pharmacology
MH  - *Bandages
MH  - Graphite/*chemistry
MH  - Humans
MH  - Nanomedicine/*methods
MH  - Structure-Activity Relationship
MH  - Wound Healing
OTO - NOTNLM
OT  - antibacterial
OT  - clinical translation
OT  - graphene
OT  - implant coating
OT  - nanocarbon
OT  - wound dressing
EDAT- 2018/03/06 06:00
MHDA- 2019/10/23 06:00
CRDT- 2018/03/06 06:00
PHST- 2017/12/01 00:00 [received]
PHST- 2018/01/16 00:00 [revised]
PHST- 2018/03/06 06:00 [pubmed]
PHST- 2019/10/23 06:00 [medline]
PHST- 2018/03/06 06:00 [entrez]
AID - 10.1002/adhm.201701406 [doi]
PST - ppublish
SO  - Adv Healthc Mater. 2018 Jul;7(13):e1701406. doi: 10.1002/adhm.201701406. Epub 
      2018 Mar 5.