PMID- 29504364
OWN - NLM
STAT- MEDLINE
DCOM- 20180417
LR  - 20190128
IS  - 0393-974X (Print)
IS  - 0393-974X (Linking)
VI  - 32
IP  - 1
DP  - 2018 Jan-Feb
TI  - Protective effects of Nano-elemental selenium against chromium-vi-induced 
      oxidative stress in broiler liver.
PG  - 47-54
AB  - The valuable role of selenium in mitigation of oxidative stress and heavy metal 
      toxicity is well-known. Thus, the aim of the current study on broiler chickens 
      was to examine whether nano elemental selenium (Nano-Se) supplementation can 
      reduce the effects of chromium VI (K2Cr2O7) toxicity. For this purpose, a total 
      of 150, one-day-old broiler chickens were allotted to five groups with three 
      replicates: control group (standard diet), poisoned group (K2Cr2O7 via drinking 
      water), protection group (K2Cr2O7 + Nano- Se), cure group (K2Cr2O7 for initial 2 
      weeks and then Nano-Se), and prevention group (opposite to the cure group). The 
      broilers were detected by the activities of marker enzymes and oxidative stress 
      markers including, aspartate aminotransferase (AST), alanine transaminase (ALT), 
      gamma-glutamyl transferase (GGT) and superoxide dismutase (SOD), glutathione 
      peroxidase (GSH-px), malondialdehyde (MDA), respectively. The (K2Cr2O7 
      administration caused histopathological damage in the liver of the chickens. 
      Moreover, changes in serum biochemical indicators and oxidative stress parameters 
      were also observed. Nano-Se supplementation increased the levels of GSH-px but 
      reduced the activities of SOD, MDA, GGT, ALT and AST in the experimental groups 
      (P less than 0.05). Our results showed that Nano-Se plays a protective role by 
      preventing the oxidative stress induced by the chromium VI in broiler chickens.
FAU - Xueting, L
AU  - Xueting L
AD  - College of Veterinary Medicine, Huazhong Agricultural University, Wuhan, P.R. 
      China.
FAU - Rehman, M U
AU  - Rehman MU
AD  - College of Veterinary Medicine, Huazhong Agricultural University, Wuhan, P.R. 
      China.
FAU - Zhang, H
AU  - Zhang H
AD  - College of Veterinary Medicine, Huazhong Agricultural University, Wuhan, P.R. 
      China.
FAU - Tian, X
AU  - Tian X
AD  - College of Veterinary Medicine, Huazhong Agricultural University, Wuhan, P.R. 
      China.
FAU - Wu, X
AU  - Wu X
AD  - College of Veterinary Medicine, Huazhong Agricultural University, Wuhan, P.R. 
      China.
FAU - Shixue
AU  - Shixue
AD  - College of Veterinary Medicine, Huazhong Agricultural University, Wuhan, P.R. 
      China.
FAU - Mehmood, K
AU  - Mehmood K
AD  - College of Veterinary Medicine, Huazhong Agricultural University, Wuhan, P.R. 
      China.
AD  - University College of Veterinary and Animal Sciences, Islamia University of 
      Bahawalpur, Punjab, Pakistan.
FAU - Zhou, D
AU  - Zhou D
AD  - College of Veterinary Medicine, Huazhong Agricultural University, Wuhan, P.R. 
      China.
LA  - eng
PT  - Letter
PL  - Italy
TA  - J Biol Regul Homeost Agents
JT  - Journal of biological regulators and homeostatic agents
JID - 8809253
RN  - 0 (Avian Proteins)
RN  - 0 (Biomarkers)
RN  - 0R0008Q3JB (Chromium)
RN  - 18540-29-9 (chromium hexavalent ion)
RN  - EC 1.- (Oxidoreductases)
RN  - EC 2.3.2.2 (gamma-Glutamyltransferase)
RN  - EC 2.6.1.1 (Aspartate Aminotransferases)
RN  - EC 2.6.1.2 (Alanine Transaminase)
RN  - H6241UJ22B (Selenium)
SB  - IM
MH  - Alanine Transaminase/metabolism
MH  - Animals
MH  - Aspartate Aminotransferases/metabolism
MH  - Avian Proteins/metabolism
MH  - Biomarkers/metabolism
MH  - Chickens
MH  - Chromium/*toxicity
MH  - Liver/*metabolism/pathology
MH  - Oxidative Stress/*drug effects
MH  - Oxidoreductases/metabolism
MH  - Selenium/*pharmacology
MH  - gamma-Glutamyltransferase/metabolism
EDAT- 2018/03/06 06:00
MHDA- 2018/04/18 06:00
CRDT- 2018/03/06 06:00
PHST- 2018/03/06 06:00 [entrez]
PHST- 2018/03/06 06:00 [pubmed]
PHST- 2018/04/18 06:00 [medline]
AID - 7 [pii]
PST - ppublish
SO  - J Biol Regul Homeost Agents. 2018 Jan-Feb;32(1):47-54.