PMID- 29506382
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20180608
LR  - 20180608
IS  - 1520-5126 (Electronic)
IS  - 0002-7863 (Linking)
VI  - 140
IP  - 11
DP  - 2018 Mar 21
TI  - Solution Self-Assemblies of Sequence-Defined Ionic Peptoid Block Copolymers.
PG  - 4100-4109
LID - 10.1021/jacs.8b00461 [doi]
AB  - A series of amphiphilic ionic peptoid block copolymers where the total number (1 
      or 3) and position of ionic monomers along the polymer chain are precisely 
      controlled have been synthesized by the submonomer method. Upon dissolution in 
      water at pH = 9, the amphiphilic peptoids self-assemble into small spherical 
      micelles having hydrodynamic radius in  approximately 5-10 nm range and critical micellar 
      concentration (CMC) in the 0.034-0.094 mg/mL range. Small-angle neutron 
      scattering (SANS) analysis of the micellar solutions revealed unprecedented 
      dependence of the micellar structure on the number and position of ionic monomers 
      along the chain. It was found that the micellar aggregation number ( N(agg)) and 
      the micellar radius ( R(m)) both increase as the ionic monomer is positioned 
      progressively away from the junction of the hydrophilic and hydrophobic segments 
      along the polymer chain. By defining an ionic monomer position number ( n) as the 
      number of monomers between the junction and the ionic monomer, N(agg) exhibited a 
      power law dependence on n with an exponent of  approximately 1/3 and  approximately 3/10 for the respective 
      singly and triply charged series. By contrast, R(m) exhibited a weaker dependence 
      on the ionic monomer position by a power law relationship with an exponent of 
       approximately 1/10 and  approximately 1/20 for the respective singly and triply charged series. Furthermore, 
      R(m) was found to scale with N(agg) in a power-law relationship with an exponent 
      of 0.32 for the singly charged series, consistent with a weakly charged ionic 
      star-like polymer model in the unscreened regime. This study demonstrated a 
      unique method to precisely tailor the structure of small spherical micelles based 
      on ionic block copolymers by controlling the sequence and position of the ionic 
      monomer.
FAU - Sternhagen, Garrett L
AU  - Sternhagen GL
AD  - Department of Chemistry and Macromolecular Studies Group , Louisiana State 
      University , Baton Rouge , Louisiana 70803 , United States.
FAU - Gupta, Sudipta
AU  - Gupta S
AUID- ORCID: 0000-0001-6642-3776
AD  - Department of Chemistry and Macromolecular Studies Group , Louisiana State 
      University , Baton Rouge , Louisiana 70803 , United States.
FAU - Zhang, Yueheng
AU  - Zhang Y
AD  - Department of Chemical and Biomolecular Engineering , Tulane University , New 
      Orleans , Louisiana 70118 , United States.
FAU - John, Vijay
AU  - John V
AUID- ORCID: 0000-0001-5426-7585
AD  - Department of Chemical and Biomolecular Engineering , Tulane University , New 
      Orleans , Louisiana 70118 , United States.
FAU - Schneider, Gerald J
AU  - Schneider GJ
AD  - Department of Chemistry and Macromolecular Studies Group , Louisiana State 
      University , Baton Rouge , Louisiana 70803 , United States.
AD  - Department of Physics , Louisiana State University , Baton Rouge , Louisiana 
      70803 , United States.
FAU - Zhang, Donghui
AU  - Zhang D
AUID- ORCID: 0000-0003-0779-6438
AD  - Department of Chemistry and Macromolecular Studies Group , Louisiana State 
      University , Baton Rouge , Louisiana 70803 , United States.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, Non-P.H.S.
DEP - 20180313
PL  - United States
TA  - J Am Chem Soc
JT  - Journal of the American Chemical Society
JID - 7503056
EDAT- 2018/03/07 06:00
MHDA- 2018/03/07 06:01
CRDT- 2018/03/07 06:00
PHST- 2018/03/07 06:00 [pubmed]
PHST- 2018/03/07 06:01 [medline]
PHST- 2018/03/07 06:00 [entrez]
AID - 10.1021/jacs.8b00461 [doi]
PST - ppublish
SO  - J Am Chem Soc. 2018 Mar 21;140(11):4100-4109. doi: 10.1021/jacs.8b00461. Epub 
      2018 Mar 13.