PMID- 29506764 OWN - NLM STAT- MEDLINE DCOM- 20190628 LR - 20190628 IS - 1873-5487 (Electronic) IS - 0188-4409 (Linking) VI - 48 IP - 7 DP - 2017 Oct TI - Association Between the Brain-derived Neurotrophic Factor Val66Met Polymorphism and Overweight/Obesity in Pediatric Population. PG - 599-608 LID - S0188-4409(18)30035-3 [pii] LID - 10.1016/j.arcmed.2018.02.005 [doi] AB - BACKGROUND: The brain-derived neurotrophic factor (BDNF) rs6265 (G196A; Val66Met) single nucleotide polymorphism has been associated with BMI and obesity in distinct populations, both adult and pediatric, with contradictory results involving either Val or Met as the risk variant. AIM OF THE STUDY: To determine the association between the BDNF Val66Met polymorphism and BMI in Mexican children and adolescents. METHODS: BDNF Val66Met genotyping by restriction fragment length polymorphism and nutritional status characterized by their BMI-for-age z-scores (BAZ) from pediatric volunteers (n = 498) were analyzed by Fisher's exact test association analysis. Standardized residuals (R) were used to determine which genotype/allele had the major influence on the significant Fisher's exact test statistic. Odds ratios were analyzed to measure the association between genotype and normal weight (>/=-2 SD < + 1 SD) and overweight (>/= + 1 SD, including obesity, Ow + Ob) status with 95% confidence intervals to estimate the precision of the effect as well as 95% credible intervals to obtain the most probable estimate. RESULTS: Comparisons between GG (Val/Val), GA (Val/Met) and AA (Met/Met) genotypes or Met homozygotes vs. Val carriers (combination of GG and GA genotypes) showed significant differences (p = 0.034 and p = 0.037, respectively) between normal weight and the combined overweight and obese pediatric subjects. Our data showed that children/adolescents homozygous for the A allele have increased risk of overweight compared to the Val carriers (Bayes OR = 4.2, 95% CI**[1.09-33.1]). CONCLUSION: This is the first study showing the significant association between the BDNF rs6265 AA (Met/Met) genotype and overweight/obesity in Mexican pediatric population. CI - Copyright (c) 2018 IMSS. Published by Elsevier Inc. All rights reserved. FAU - Martinez-Ezquerro, Jose Dario AU - Martinez-Ezquerro JD AD - Unidad de Investigacion Medica en Genetica Humana, Hospital de Pediatria, Centro Medico Nacional Siglo XXI, Instituto Mexicano del Seguro Social, Ciudad de Mexico, Mexico; Posgrado en Ciencias Biologicas, Universidad Nacional Autonoma de Mexico, Av. Ciudad Universitaria, Coyoacan, Ciudad de Mexico, Mexico. FAU - Rendon-Macias, Mario Enrique AU - Rendon-Macias ME AD - Unidad de Investigacion en Epidemiologia Clinica, Hospital de Pediatria, Centro Medico Nacional Siglo XXI, Instituto Mexicano del Seguro Social, Ciudad de Mexico, Mexico. FAU - Zamora-Mendoza, Gerardo AU - Zamora-Mendoza G AD - Unidad de Investigacion Medica en Genetica Humana, Hospital de Pediatria, Centro Medico Nacional Siglo XXI, Instituto Mexicano del Seguro Social, Ciudad de Mexico, Mexico; Posgrado en Ciencias Biologicas, Universidad Nacional Autonoma de Mexico, Av. Ciudad Universitaria, Coyoacan, Ciudad de Mexico, Mexico. FAU - Serrano-Meneses, Jacobo AU - Serrano-Meneses J AD - Unidad de Investigacion en Epidemiologia Clinica, Hospital de Pediatria, Centro Medico Nacional Siglo XXI, Instituto Mexicano del Seguro Social, Ciudad de Mexico, Mexico. FAU - Rosales-Rodriguez, Beatriz AU - Rosales-Rodriguez B AD - Unidad de Investigacion Medica en Genetica Humana, Hospital de Pediatria, Centro Medico Nacional Siglo XXI, Instituto Mexicano del Seguro Social, Ciudad de Mexico, Mexico; Posgrado en Ciencias Biologicas, Universidad Nacional Autonoma de Mexico, Av. Ciudad Universitaria, Coyoacan, Ciudad de Mexico, Mexico. FAU - Escalante-Bautista, Deyanira AU - Escalante-Bautista D AD - Unidad de Investigacion Medica en Genetica Humana, Hospital de Pediatria, Centro Medico Nacional Siglo XXI, Instituto Mexicano del Seguro Social, Ciudad de Mexico, Mexico. FAU - Rodriguez-Cruz, Maricela AU - Rodriguez-Cruz M AD - Unidad de Investigacion Medica en Nutricion, Hospital de Pediatria, Centro Medico Nacional Siglo XXI, Instituto Mexicano del Seguro Social, Ciudad de Mexico, Mexico. FAU - Sanchez-Gonzalez, Raul AU - Sanchez-Gonzalez R AD - Unidad de Investigacion Medica en Nutricion, Hospital de Pediatria, Centro Medico Nacional Siglo XXI, Instituto Mexicano del Seguro Social, Ciudad de Mexico, Mexico. FAU - Arellano-Pineda, Yessica AU - Arellano-Pineda Y AD - Unidad de Investigacion Medica en Nutricion, Hospital de Pediatria, Centro Medico Nacional Siglo XXI, Instituto Mexicano del Seguro Social, Ciudad de Mexico, Mexico. FAU - Lopez-Alarcon, Mardia AU - Lopez-Alarcon M AD - Unidad de Investigacion Medica en Nutricion, Hospital de Pediatria, Centro Medico Nacional Siglo XXI, Instituto Mexicano del Seguro Social, Ciudad de Mexico, Mexico. FAU - Zampedri, Maria Cecilia AU - Zampedri MC AD - Laboratorio de Genomica Funcional, Instituto Nacional de Medicina Genomica, Ciudad de Mexico, Mexico. FAU - Rosas-Vargas, Haydee AU - Rosas-Vargas H AD - Unidad de Investigacion Medica en Genetica Humana, Hospital de Pediatria, Centro Medico Nacional Siglo XXI, Instituto Mexicano del Seguro Social, Ciudad de Mexico, Mexico. Electronic address: hayrov@gmail.com. LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't DEP - 20180303 PL - United States TA - Arch Med Res JT - Archives of medical research JID - 9312706 RN - 0 (Brain-Derived Neurotrophic Factor) RN - 0 (Genetic Markers) RN - 7171WSG8A2 (BDNF protein, human) SB - IM MH - Adolescent MH - Bayes Theorem MH - Brain-Derived Neurotrophic Factor/*genetics MH - Case-Control Studies MH - Child MH - Child, Preschool MH - Female MH - Genetic Markers MH - *Genetic Predisposition to Disease MH - Genotype MH - Humans MH - Male MH - Mexico MH - Odds Ratio MH - Pediatric Obesity/*genetics MH - *Polymorphism, Single Nucleotide OTO - NOTNLM OT - BDNF OT - BMI z-score OT - Body weight OT - Obesity OT - Overweight EDAT- 2018/03/07 06:00 MHDA- 2019/06/30 06:00 CRDT- 2018/03/07 06:00 PHST- 2017/11/24 00:00 [received] PHST- 2018/02/22 00:00 [accepted] PHST- 2018/03/07 06:00 [pubmed] PHST- 2019/06/30 06:00 [medline] PHST- 2018/03/07 06:00 [entrez] AID - S0188-4409(18)30035-3 [pii] AID - 10.1016/j.arcmed.2018.02.005 [doi] PST - ppublish SO - Arch Med Res. 2017 Oct;48(7):599-608. doi: 10.1016/j.arcmed.2018.02.005. Epub 2018 Mar 3.