PMID- 29506878
OWN - NLM
STAT- MEDLINE
DCOM- 20180928
LR  - 20220408
IS  - 1618-0631 (Electronic)
IS  - 0344-0338 (Linking)
VI  - 214
IP  - 5
DP  - 2018 May
TI  - Up-regulated expression of SNHG6 predicts poor prognosis in colorectal cancer.
PG  - 784-789
LID - S0344-0338(17)31036-1 [pii]
LID - 10.1016/j.prp.2017.12.014 [doi]
AB  - Long non-coding RNAs (lncRNAs) have been shown to play important roles in tumor 
      formation and development. Small nucleolar RNA host gene 6 (SNHG6) is a recently 
      identified cancer-related lncRNA, and its role in colorectal cancer (CRC) remains 
      to be explored. The aim of this study was to evaluate the expression and function 
      of SNHG6 in CRC. The expression of SNHG6 was detected by real time quantitative 
      RT-PCR (qRT-PCR) in 74 CRC tissues and matched noncancerous tissues (NCTs). 
      Relationships between the expression levels of SNHG6 and various 
      clinicopathological features were analyzed by Chi-square test. The Kaplan-Meier 
      method and log-rank test were applied to compare the survival distribution 
      between different groups. CCK8 assay and colony formation assay were used to 
      measure the effect of SNGH6 on cell proliferation. Flow cytometric analysis was 
      performed to measure the effect of SNHG6 on cell cycle and apoptosis. Our results 
      showed that SNHG6 was up-regulated more than 1.5-fold in 50.0% (37/74) of CRC 
      tissues compared with paired NCTs (P < 0.0001). High level of SNHG6 expression 
      was strongly associated with advanced tumor stage (P = 0.026) and predicted poor 
      prognosis of CRC (P = 0.0215). The Cox proportional hazards model demonstrated 
      that SNHG6 expression was an independent prognostic factor for CRC (HR, 2.568; 
      95% CI, 1.055-6.252; P = 0.038). Furthermore, SNHG6 knockdown by siRNA could 
      inhibit cell proliferation, cell cycle progression, and induce apoptosis. Taken 
      together, SNHG6 functions as an oncogene in CRC and appears as a novel 
      prognositic factor for CRC patients.
CI  - Copyright (c) 2018 Elsevier GmbH. All rights reserved.
FAU - Li, Min
AU  - Li M
AD  - Wuxi Cancer Institute, Affiliated Hospital of Jiangnan University, Wuxi, Jiangsu, 
      214062, China.
FAU - Bian, Zehua
AU  - Bian Z
AD  - Wuxi Cancer Institute, Affiliated Hospital of Jiangnan University, Wuxi, Jiangsu, 
      214062, China; Cancer Epigenetics Program, Wuxi Medical School, Jiangnan 
      University, Wuxi, Jiangsu 214122, China.
FAU - Yao, Surui
AU  - Yao S
AD  - Wuxi Cancer Institute, Affiliated Hospital of Jiangnan University, Wuxi, Jiangsu, 
      214062, China.
FAU - Zhang, Jia
AU  - Zhang J
AD  - Wuxi Cancer Institute, Affiliated Hospital of Jiangnan University, Wuxi, Jiangsu, 
      214062, China.
FAU - Jin, Guoying
AU  - Jin G
AD  - Wuxi Cancer Institute, Affiliated Hospital of Jiangnan University, Wuxi, Jiangsu, 
      214062, China.
FAU - Wang, Xue
AU  - Wang X
AD  - Cancer Epigenetics Program, Wuxi Medical School, Jiangnan University, Wuxi, 
      Jiangsu 214122, China.
FAU - Yin, Yuan
AU  - Yin Y
AD  - Wuxi Cancer Institute, Affiliated Hospital of Jiangnan University, Wuxi, Jiangsu, 
      214062, China; Cancer Epigenetics Program, Wuxi Medical School, Jiangnan 
      University, Wuxi, Jiangsu 214122, China.
FAU - Huang, Zhaohui
AU  - Huang Z
AD  - Wuxi Cancer Institute, Affiliated Hospital of Jiangnan University, Wuxi, Jiangsu, 
      214062, China; Cancer Epigenetics Program, Wuxi Medical School, Jiangnan 
      University, Wuxi, Jiangsu 214122, China. Electronic address: hzhwxsy@126.com.
LA  - eng
PT  - Journal Article
DEP - 20180103
PL  - Germany
TA  - Pathol Res Pract
JT  - Pathology, research and practice
JID - 7806109
RN  - 0 (Biomarkers, Tumor)
RN  - 0 (RNA, Long Noncoding)
RN  - 0 (long non-coding RNA SNHG6, human)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Apoptosis/genetics
MH  - Biomarkers, Tumor/metabolism
MH  - Cell Line, Tumor
MH  - Cell Proliferation/genetics
MH  - Colorectal Neoplasms/diagnosis/*pathology
MH  - Female
MH  - *Gene Expression Regulation, Neoplastic
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Prognosis
MH  - RNA, Long Noncoding/*genetics
MH  - Up-Regulation
OTO - NOTNLM
OT  - Colorectal cancer
OT  - Long non-coding RNA
OT  - Prognosis
OT  - Small nucleolar RNA host gene 6 (SNHG6)
EDAT- 2018/03/07 06:00
MHDA- 2018/10/03 06:00
CRDT- 2018/03/07 06:00
PHST- 2017/10/16 00:00 [received]
PHST- 2017/12/03 00:00 [revised]
PHST- 2017/12/31 00:00 [accepted]
PHST- 2018/03/07 06:00 [pubmed]
PHST- 2018/10/03 06:00 [medline]
PHST- 2018/03/07 06:00 [entrez]
AID - S0344-0338(17)31036-1 [pii]
AID - 10.1016/j.prp.2017.12.014 [doi]
PST - ppublish
SO  - Pathol Res Pract. 2018 May;214(5):784-789. doi: 10.1016/j.prp.2017.12.014. Epub 
      2018 Jan 3.