PMID- 29507375
OWN - NLM
STAT- MEDLINE
DCOM- 20191028
LR  - 20191028
IS  - 2045-2322 (Electronic)
IS  - 2045-2322 (Linking)
VI  - 8
IP  - 1
DP  - 2018 Mar 5
TI  - Low intensity repetitive transcranial magnetic stimulation modulates skilled 
      motor learning in adult mice.
PG  - 4016
LID - 10.1038/s41598-018-22385-8 [doi]
LID - 4016
AB  - Repetitive transcranial magnetic stimulation (rTMS) is commonly used to modulate 
      cortical plasticity in clinical and non-clinical populations. Clinically, rTMS is 
      delivered to targeted regions of the cortex at high intensities (>1 T). We have 
      previously shown that even at low intensities, rTMS induces structural and 
      molecular plasticity in the rodent cortex. To determine whether low intensity 
      rTMS (LI-rTMS) alters behavioural performance, daily intermittent theta burst 
      LI-rTMS (120 mT) or sham was delivered as a priming or consolidating stimulus to 
      mice completing 10 consecutive days of skilled reaching training. Relative to 
      sham, priming LI-rTMS (before each training session), increased skill accuracy 
      (~9%) but did not alter the rate of learning over time. In contrast, 
      consolidating LI-rTMS (after each training session), resulted in a small increase 
      in the rate of learning (an additional ~1.6% each day) but did not alter the 
      daily skill accuracy. Changes in behaviour with LI-rTMS were not accompanied with 
      long lasting changes in brain-derived neurotrophic factor (BDNF) expression or in 
      the expression of plasticity markers at excitatory and inhibitory synapses for 
      either priming or consolidation groups. These results suggest that LI-rTMS can 
      alter specific aspects of skilled motor learning in a manner dependent on the 
      timing of intervention.
FAU - Tang, Alexander D
AU  - Tang AD
AUID- ORCID: 0000-0002-3832-847X
AD  - Experimental and Regenerative Neurosciences, School of Animal Biology, University 
      of Western Australia, Perth, Australia. adtang.research@gmail.com.
AD  - Neuronal Rhythms in Movement Unit, Okinawa Institute of Science and Technology 
      Graduate University, Okinawa, Japan. adtang.research@gmail.com.
FAU - Bennett, William
AU  - Bennett W
AUID- ORCID: 0000-0002-1559-3027
AD  - Wicking Dementia Research and Education Centre, University of Tasmania, Hobart, 
      Australia. bill.bennett@utas.edu.au.
FAU - Hadrill, Claire
AU  - Hadrill C
AD  - Wicking Dementia Research and Education Centre, University of Tasmania, Hobart, 
      Australia.
FAU - Collins, Jessica
AU  - Collins J
AD  - Wicking Dementia Research and Education Centre, University of Tasmania, Hobart, 
      Australia.
FAU - Fulopova, Barbora
AU  - Fulopova B
AD  - Wicking Dementia Research and Education Centre, University of Tasmania, Hobart, 
      Australia.
FAU - Wills, Karen
AU  - Wills K
AD  - Menzies Institute for Medical Research, University of Tasmania, Hobart, 
      Australia.
FAU - Bindoff, Aidan
AU  - Bindoff A
AUID- ORCID: 0000-0002-0943-2702
AD  - Wicking Dementia Research and Education Centre, University of Tasmania, Hobart, 
      Australia.
FAU - Puri, Rohan
AU  - Puri R
AD  - Human Motor Control Laboratory, School of Medicine, University of Tasmania, 
      Hobart, Australia.
FAU - Garry, Michael I
AU  - Garry MI
AD  - Human Motor Control Laboratory, School of Medicine, University of Tasmania, 
      Hobart, Australia.
FAU - Hinder, Mark R
AU  - Hinder MR
AD  - Human Motor Control Laboratory, School of Medicine, University of Tasmania, 
      Hobart, Australia.
FAU - Summers, Jeffery J
AU  - Summers JJ
AD  - Human Motor Control Laboratory, School of Medicine, University of Tasmania, 
      Hobart, Australia.
AD  - Research Institute for Sport and Exercise Sciences, Liverpool John Moores 
      University, Liverpool, United Kingdom.
FAU - Rodger, Jennifer
AU  - Rodger J
AUID- ORCID: 0000-0003-3413-4229
AD  - Experimental and Regenerative Neurosciences, School of Animal Biology, University 
      of Western Australia, Perth, Australia.
FAU - Canty, Alison J
AU  - Canty AJ
AD  - Wicking Dementia Research and Education Centre, University of Tasmania, Hobart, 
      Australia.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20180305
PL  - England
TA  - Sci Rep
JT  - Scientific reports
JID - 101563288
RN  - 0 (Bdnf protein, mouse)
RN  - 0 (Brain-Derived Neurotrophic Factor)
SB  - IM
MH  - Animals
MH  - Brain-Derived Neurotrophic Factor/metabolism
MH  - *Learning
MH  - Male
MH  - Mice
MH  - Mice, Inbred C57BL
MH  - *Motor Activity
MH  - Transcranial Magnetic Stimulation/*methods
PMC - PMC5838100
COIS- The authors declare no competing interests.
EDAT- 2018/03/07 06:00
MHDA- 2019/10/29 06:00
PMCR- 2018/03/05
CRDT- 2018/03/07 06:00
PHST- 2017/11/13 00:00 [received]
PHST- 2018/02/22 00:00 [accepted]
PHST- 2018/03/07 06:00 [entrez]
PHST- 2018/03/07 06:00 [pubmed]
PHST- 2019/10/29 06:00 [medline]
PHST- 2018/03/05 00:00 [pmc-release]
AID - 10.1038/s41598-018-22385-8 [pii]
AID - 22385 [pii]
AID - 10.1038/s41598-018-22385-8 [doi]
PST - epublish
SO  - Sci Rep. 2018 Mar 5;8(1):4016. doi: 10.1038/s41598-018-22385-8.