PMID- 29507866 OWN - NLM STAT- PubMed-not-MEDLINE LR - 20201001 IS - 2328-8957 (Print) IS - 2328-8957 (Electronic) IS - 2328-8957 (Linking) VI - 5 IP - 2 DP - 2018 Feb TI - Adalimumab for Corticosteroid and Infliximab-Resistant Immune Reconstitution Inflammatory Syndrome in the Setting of TB/HIV Coinfection. PG - ofy027 LID - 10.1093/ofid/ofy027 [doi] LID - ofy027 AB - Corticosteroids are the mainstay of therapy for immune reconstitution inflammatory syndrome (IRIS). However, little is known about how to treat IRIS unresponsive to steroids. We report a patient with HIV-TB coinfection who was unresponsive to first prednisolone and then infliximab but whose IRIS resolved with adalimumab. FAU - Lwin, Nilar AU - Lwin N AD - Department of Immunology and Infectious Diseases, John Hunter Hospital, Newcastle, NSW, Australia. FAU - Boyle, Michael AU - Boyle M AD - Department of Immunology and Infectious Diseases, John Hunter Hospital, Newcastle, NSW, Australia. AD - School of Medicine and Public Health, University of Newcastle, Newcastle, NSW, Australia. FAU - Davis, Joshua S AU - Davis JS AD - Department of Immunology and Infectious Diseases, John Hunter Hospital, Newcastle, NSW, Australia. AD - School of Medicine and Public Health, University of Newcastle, Newcastle, NSW, Australia. AD - Global and Tropical Health Division, Menzies School of Health Research, Darwin, NT, Australia. LA - eng PT - Journal Article DEP - 20180130 PL - United States TA - Open Forum Infect Dis JT - Open forum infectious diseases JID - 101637045 PMC - PMC5825900 OTO - NOTNLM OT - HIV OT - adalimumab OT - immune reconstitution OT - steroid OT - tuberculosis EDAT- 2018/03/07 06:00 MHDA- 2018/03/07 06:01 PMCR- 2018/01/30 CRDT- 2018/03/07 06:00 PHST- 2017/10/10 00:00 [received] PHST- 2018/01/24 00:00 [accepted] PHST- 2018/03/07 06:00 [entrez] PHST- 2018/03/07 06:00 [pubmed] PHST- 2018/03/07 06:01 [medline] PHST- 2018/01/30 00:00 [pmc-release] AID - ofy027 [pii] AID - 10.1093/ofid/ofy027 [doi] PST - epublish SO - Open Forum Infect Dis. 2018 Jan 30;5(2):ofy027. doi: 10.1093/ofid/ofy027. eCollection 2018 Feb.