PMID- 29507906
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20201001
IS  - 2471-254X (Electronic)
IS  - 2471-254X (Linking)
VI  - 2
IP  - 3
DP  - 2018 Mar
TI  - Interleukins-17 and 27 promote liver regeneration by sequentially inducing 
      progenitor cell expansion and differentiation.
PG  - 329-343
LID - 10.1002/hep4.1145 [doi]
AB  - Liver progenitor cells (LPCs)/ductular reactions (DRs) are associated with 
      inflammation and implicated in the pathogenesis of chronic liver diseases. 
      However, how inflammation regulates LPCs/DRs remains largely unknown. 
      Identification of inflammatory processes that involve LPC activation and 
      expansion represent a key step in understanding the pathogenesis of liver 
      diseases. In the current study, we found that diverse types of chronic liver 
      diseases are associated with elevation of infiltrated interleukin 
      (IL)-17-positive (+) cells and cytokeratin 19 (CK19)(+) LPCs, and both cell types 
      colocalized and their numbers positively correlated with each other. The role of 
      IL-17 in the induction of LPCs was examined in a mouse model fed a 
      choline-deficient and ethionine-supplemented (CDE) diet. Feeding of wild-type 
      mice with the CDE diet markedly elevated CK19(+)Ki67(+) proliferating LPCs and 
      hepatic inflammation. Disruption of the IL-17 gene or IL-27 receptor, alpha 
      subunit (WSX-1) gene abolished CDE diet-induced LPC expansion and inflammation. 
      In vitro treatment with IL-17 promoted proliferation of bipotential murine oval 
      liver cells (a liver progenitor cell line) and markedly up-regulated IL-27 
      expression in macrophages. Treatment with IL-27 favored the differentiation of 
      bipotential murine oval liver cells and freshly isolated LPCs into hepatocytes. 
      Conclusion: The current data provide evidence for a collaborative role between 
      IL-17 and IL-27 in promoting LPC expansion and differentiation, respectively, 
      thereby contributing to liver regeneration. (Hepatology Communications 
      2018;2:329-343).
FAU - Guillot, Adrien
AU  - Guillot A
AD  - Universite Paris-Est, UMR-S955 Creteil France.
AD  - Institut National de la Sante et de la Recherche Medicale (INSERM) U955, Institut 
      Mondor de Recherche Biomedicale Creteil France.
AD  - Laboratory of Liver Diseases, National Institute on Alcohol Abuse and Alcoholism, 
      National Institutes of Health Bethesda MD.
FAU - Gasmi, Imene
AU  - Gasmi I
AD  - Universite Paris-Est, UMR-S955 Creteil France.
AD  - Institut National de la Sante et de la Recherche Medicale (INSERM) U955, Institut 
      Mondor de Recherche Biomedicale Creteil France.
FAU - Brouillet, Arthur
AU  - Brouillet A
AD  - Universite Paris-Est, UMR-S955 Creteil France.
AD  - Institut National de la Sante et de la Recherche Medicale (INSERM) U955, Institut 
      Mondor de Recherche Biomedicale Creteil France.
FAU - Ait-Ahmed, Yeni
AU  - Ait-Ahmed Y
AD  - Universite Paris-Est, UMR-S955 Creteil France.
AD  - Institut National de la Sante et de la Recherche Medicale (INSERM) U955, Institut 
      Mondor de Recherche Biomedicale Creteil France.
FAU - Calderaro, Julien
AU  - Calderaro J
AUID- ORCID: 0000-0002-5370-0807
AD  - Universite Paris-Est, UMR-S955 Creteil France.
AD  - Institut National de la Sante et de la Recherche Medicale (INSERM) U955, Institut 
      Mondor de Recherche Biomedicale Creteil France.
AD  - Departement de Pathologie, Hopital Henri Mondor Universite Paris-Est Creteil 
      France.
FAU - Ruiz, Isaac
AU  - Ruiz I
AD  - Universite Paris-Est, UMR-S955 Creteil France.
AD  - Institut National de la Sante et de la Recherche Medicale (INSERM) U955, Institut 
      Mondor de Recherche Biomedicale Creteil France.
AD  - Departement d'Hepatologie, Universite Paris-Est Creteil France.
FAU - Gao, Bin
AU  - Gao B
AD  - Laboratory of Liver Diseases, National Institute on Alcohol Abuse and Alcoholism, 
      National Institutes of Health Bethesda MD.
FAU - Lotersztajn, Sophie
AU  - Lotersztajn S
AD  - Universite Paris-Est, UMR-S955 Creteil France.
AD  - Institut National de la Sante et de la Recherche Medicale (INSERM) U955, Institut 
      Mondor de Recherche Biomedicale Creteil France.
AD  - Present address: Present address for Sophie Lotersztajn is INSERM-U1149, 
      CNRS-ERL8252, Centre de Recherche sur l'Inflammation, Paris, France, and Sorbonne 
      Paris Cite, Laboratoire d'Excellence Inflamex, Faculte de Medecine, Site Xavier 
      Bichat Universite Paris Diderot Paris France.
FAU - Pawlotsky, Jean-Michel
AU  - Pawlotsky JM
AD  - Universite Paris-Est, UMR-S955 Creteil France.
AD  - Institut National de la Sante et de la Recherche Medicale (INSERM) U955, Institut 
      Mondor de Recherche Biomedicale Creteil France.
FAU - Lafdil, Fouad
AU  - Lafdil F
AD  - Universite Paris-Est, UMR-S955 Creteil France.
AD  - Institut National de la Sante et de la Recherche Medicale (INSERM) U955, Institut 
      Mondor de Recherche Biomedicale Creteil France.
AD  - Institut Universitaire de France Paris France.
LA  - eng
PT  - Journal Article
DEP - 20180130
PL  - United States
TA  - Hepatol Commun
JT  - Hepatology communications
JID - 101695860
PMC - PMC5831061
EDAT- 2018/03/07 06:00
MHDA- 2018/03/07 06:01
PMCR- 2018/01/30
CRDT- 2018/03/07 06:00
PHST- 2017/07/24 00:00 [received]
PHST- 2017/12/06 00:00 [revised]
PHST- 2017/12/06 00:00 [accepted]
PHST- 2018/03/07 06:00 [entrez]
PHST- 2018/03/07 06:00 [pubmed]
PHST- 2018/03/07 06:01 [medline]
PHST- 2018/01/30 00:00 [pmc-release]
AID - HEP41145 [pii]
AID - 10.1002/hep4.1145 [doi]
PST - epublish
SO  - Hepatol Commun. 2018 Jan 30;2(3):329-343. doi: 10.1002/hep4.1145. eCollection 
      2018 Mar.