PMID- 29508991
OWN - NLM
STAT- MEDLINE
DCOM- 20190611
LR  - 20190613
IS  - 1948-7193 (Electronic)
IS  - 1948-7193 (Linking)
VI  - 9
IP  - 6
DP  - 2018 Jun 20
TI  - Mass Spectrometry Imaging Shows Cocaine and Methylphenidate Have Opposite Effects 
      on Major Lipids in Drosophila Brain.
PG  - 1462-1468
LID - 10.1021/acschemneuro.8b00046 [doi]
AB  - Time-of-flight secondary ion mass spectrometry (ToF-SIMS) was used to study the 
      effects of cocaine versus methylphenidate administration on both the localization 
      and abundance of lipids in Drosophila melanogaster brain. A J105 ToF-SIMS with a 
      40 keV gas cluster primary ion source enabled us to probe molecular ions of 
      biomolecules on the fly with a spatial resolution of  approximately 3 mum, giving us unique 
      insights into the effect of these drugs on molecular lipids in the nervous 
      system. Significant changes in phospholipid composition were observed in the 
      central brain for both. Principal components image analysis revealed that changes 
      occurred mainly for phosphatidylcholines, phosphatidylethanolamines, and 
      phosphatidylinositols. When the lipid changes caused by cocaine were compared 
      with those induced by methylphenidate, it was shown that these drugs exert 
      opposite effects on the brain lipid structure. We speculate that this might 
      relate to the molecular mechanism of cognition and memory.
FAU - Philipsen, Mai H
AU  - Philipsen MH
AD  - Department of Chemistry and Chemical Engineering , Chalmers University of 
      Technology , Gothenburg 412 96 , Sweden.
AD  - Go:IMS , Chalmers University of Technology and University of Gothenburg , 
      Gothenburg 412 96 , Sweden.
FAU - Phan, Nhu T N
AU  - Phan NTN
AD  - Department of Chemistry and Molecular Biology , University of Gothenburg , 
      Gothenburg 412 96 , Sweden.
AD  - Go:IMS , Chalmers University of Technology and University of Gothenburg , 
      Gothenburg 412 96 , Sweden.
AD  - Institute of Neuro- and Sensory Physiology , Goettingen University Medical Center 
      , Goettingen 37073 , Germany.
FAU - Fletcher, John S
AU  - Fletcher JS
AUID- ORCID: 0000-0002-9418-8571
AD  - Department of Chemistry and Molecular Biology , University of Gothenburg , 
      Gothenburg 412 96 , Sweden.
AD  - Go:IMS , Chalmers University of Technology and University of Gothenburg , 
      Gothenburg 412 96 , Sweden.
FAU - Malmberg, Per
AU  - Malmberg P
AUID- ORCID: 0000-0002-6487-7851
AD  - Department of Chemistry and Chemical Engineering , Chalmers University of 
      Technology , Gothenburg 412 96 , Sweden.
AD  - Go:IMS , Chalmers University of Technology and University of Gothenburg , 
      Gothenburg 412 96 , Sweden.
FAU - Ewing, Andrew G
AU  - Ewing AG
AUID- ORCID: 0000-0002-2084-0133
AD  - Department of Chemistry and Chemical Engineering , Chalmers University of 
      Technology , Gothenburg 412 96 , Sweden.
AD  - Department of Chemistry and Molecular Biology , University of Gothenburg , 
      Gothenburg 412 96 , Sweden.
AD  - Go:IMS , Chalmers University of Technology and University of Gothenburg , 
      Gothenburg 412 96 , Sweden.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20180320
PL  - United States
TA  - ACS Chem Neurosci
JT  - ACS chemical neuroscience
JID - 101525337
RN  - 0 (Phosphatidylethanolamines)
RN  - 207ZZ9QZ49 (Methylphenidate)
RN  - I5Y540LHVR (Cocaine)
SB  - IM
MH  - Animals
MH  - Brain/*drug effects
MH  - Cocaine/*pharmacology
MH  - Drosophila
MH  - Drosophila melanogaster/metabolism
MH  - Lipid Metabolism/*drug effects
MH  - Methylphenidate/*pharmacology
MH  - Phosphatidylethanolamines/pharmacology
MH  - Principal Component Analysis/methods
MH  - *Spectrometry, Mass, Secondary Ion/methods
OTO - NOTNLM
OT  - Drosophila
OT  - Mass spectrometry imaging
OT  - cocaine
OT  - methylphenidate
OT  - phospholipids
EDAT- 2018/03/07 06:00
MHDA- 2019/06/14 06:00
CRDT- 2018/03/07 06:00
PHST- 2018/03/07 06:00 [pubmed]
PHST- 2019/06/14 06:00 [medline]
PHST- 2018/03/07 06:00 [entrez]
AID - 10.1021/acschemneuro.8b00046 [doi]
PST - ppublish
SO  - ACS Chem Neurosci. 2018 Jun 20;9(6):1462-1468. doi: 10.1021/acschemneuro.8b00046. 
      Epub 2018 Mar 20.