PMID- 29509296
OWN - NLM
STAT- MEDLINE
DCOM- 20190916
LR  - 20190916
IS  - 1440-1681 (Electronic)
IS  - 0305-1870 (Linking)
VI  - 45
IP  - 7
DP  - 2018 Jul
TI  - Vitamin B complex mitigates cardiac dysfunction in high-methionine diet-induced 
      hyperhomocysteinemia.
PG  - 683-693
LID - 10.1111/1440-1681.12930 [doi]
AB  - This research is designed to test the hypothesis that elevated homocysteine (Hcy) 
      levels in vivo, caused by a deficit in vitamin B complex, promote changes in 
      cardiac function and redox status that lead to heart failure. In order to conduct 
      the study, we used adult male Wistar albino rats (n = 30; 4 weeks old; 100 +/- 15 g 
      body weight). Hyperhomocysteinaemia (HHcy) in these animals was achieved by 
      dietary manipulation. For 4 weeks, the animals were fed with a standard rodent 
      chow (control, CF), a diet enriched in methionine with no deficiency in B 
      vitamins (i.e., folic acid, B6 and B12) (HMNV) or a diet enriched in methionine 
      and deficient in B vitamins (HMLV). After 28 days of dietary manipulation, all 
      animals were killed. The rat hearts were isolated and retrogradely perfused 
      according to the Langendorff technique at a gradually increasing perfusion 
      pressure. We found a negative correlation between elevated serum Hcy and total 
      body and heart weight. The maximum rate of left ventricular pressure development 
      was significantly increased in the HMNV group compared with in the other groups. 
      Systolic left ventricular pressure was significantly changed in all groups. HHcy 
      induces remodelling of the cardiac tissues, as moderate HHcy is associated with 
      more prominent interstitial and perivascular fibrosis. Our results suggest that a 
      high methionine diet without vitamin B complex causes profound negative effects 
      associated with HHcy.
CI  - (c) 2018 John Wiley & Sons Australia, Ltd.
FAU - Jeremic, Jovana
AU  - Jeremic J
AD  - Department of Pharmacy, Faculty of Medical Sciences, University of Kragujevac, 
      Kragujevac, Serbia.
FAU - Nikolic Turnic, Tamara
AU  - Nikolic Turnic T
AD  - Department of Pharmacy, Faculty of Medical Sciences, University of Kragujevac, 
      Kragujevac, Serbia.
FAU - Zivkovic, Vladimir
AU  - Zivkovic V
AD  - Department of Physiology, Faculty of Medical Sciences, University of Kragujevac, 
      Kragujevac, Serbia.
FAU - Jeremic, Nevena
AU  - Jeremic N
AD  - Department of Pharmacy, Faculty of Medical Sciences, University of Kragujevac, 
      Kragujevac, Serbia.
FAU - Milosavljevic, Isidora
AU  - Milosavljevic I
AD  - Department of Pharmacy, Faculty of Medical Sciences, University of Kragujevac, 
      Kragujevac, Serbia.
FAU - Srejovic, Ivan
AU  - Srejovic I
AD  - Department of Physiology, Faculty of Medical Sciences, University of Kragujevac, 
      Kragujevac, Serbia.
FAU - Obrenovic, Radmila
AU  - Obrenovic R
AD  - Institute for Medical Biochemistry, Clinical Centre of Serbia, Belgrade, Serbia.
FAU - Jancic, Snezana
AU  - Jancic S
AD  - Department of Pathology, Faculty of Medical Sciences, University of Kragujevac, 
      Kragujevac, Serbia.
FAU - Rakocevic, Milena
AU  - Rakocevic M
AD  - Department of Pathology, Faculty of Medical Sciences, University of Kragujevac, 
      Kragujevac, Serbia.
FAU - Matic, Stevan
AU  - Matic S
AD  - Department of Pathology, Faculty of Medical Sciences, University of Kragujevac, 
      Kragujevac, Serbia.
FAU - Djuric, Dragan
AU  - Djuric D
AD  - Institute of Medical Physiology "Richard Burian", School of Medicine, University 
      of Belgrade, Belgrade, Serbia.
FAU - Jakovljevic, Vladimir
AU  - Jakovljevic V
AUID- ORCID: 0000-0002-0071-8376
AD  - Department of Physiology, Faculty of Medical Sciences, University of Kragujevac, 
      Kragujevac, Serbia.
AD  - Department of Human Pathology, 1st Moscow State Medical, University IM Sechenov, 
      Moscow, Russian Federation.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20180406
PL  - Australia
TA  - Clin Exp Pharmacol Physiol
JT  - Clinical and experimental pharmacology & physiology
JID - 0425076
RN  - 0 (Reactive Oxygen Species)
RN  - 0LVT1QZ0BA (Homocysteine)
RN  - 12001-76-2 (Vitamin B Complex)
RN  - AE28F7PNPL (Methionine)
RN  - EC 1.11.1.6 (Catalase)
RN  - EC 1.15.1.1 (Superoxide Dismutase)
RN  - GAN16C9B8O (Glutathione)
SB  - IM
MH  - Animals
MH  - Catalase/metabolism
MH  - *Diet
MH  - Glutathione/metabolism
MH  - Heart/*drug effects/*physiopathology
MH  - Homocysteine/metabolism
MH  - Hyperhomocysteinemia/chemically induced/metabolism/pathology/*physiopathology
MH  - Male
MH  - Methionine/*adverse effects
MH  - Rats
MH  - Rats, Wistar
MH  - Reactive Oxygen Species/metabolism
MH  - Superoxide Dismutase/metabolism
MH  - Vitamin B Complex/*pharmacology
OTO - NOTNLM
OT  - cardiac function
OT  - fibrosis
OT  - hyperhomocysteinaemia
OT  - oxidative stress
OT  - vitamin B complex
EDAT- 2018/03/07 06:00
MHDA- 2019/09/17 06:00
CRDT- 2018/03/07 06:00
PHST- 2017/11/21 00:00 [received]
PHST- 2018/02/20 00:00 [revised]
PHST- 2018/02/22 00:00 [accepted]
PHST- 2018/03/07 06:00 [pubmed]
PHST- 2019/09/17 06:00 [medline]
PHST- 2018/03/07 06:00 [entrez]
AID - 10.1111/1440-1681.12930 [doi]
PST - ppublish
SO  - Clin Exp Pharmacol Physiol. 2018 Jul;45(7):683-693. doi: 10.1111/1440-1681.12930. 
      Epub 2018 Apr 6.