PMID- 29509714
OWN - NLM
STAT- MEDLINE
DCOM- 20180813
LR  - 20181207
IS  - 1420-3049 (Electronic)
IS  - 1420-3049 (Linking)
VI  - 23
IP  - 3
DP  - 2018 Mar 6
TI  - Forsythoside A Modulates Zymosan-Induced Peritonitis in Mice.
LID - 10.3390/molecules23030593 [doi]
LID - 593
AB  - Acute inflammation is a protective response of the host to physical injury and 
      invading infection. Timely treatment of acute inflammatory reactions is essential 
      to prevent damage to organisms that can eventually lead to chronic inflammation. 
      Forsythoside A (FTA), an active constituent of Forsythia suspensa, has been 
      reported to have anti-inflammatory, antioxidant, and antibacterial properties. 
      Despite increasing knowledge of its anti-inflammatory effects, the mechanism and 
      the effects on acute inflammation are poorly understood. This study is aimed at 
      exploring the pro-resolving effects of FTA on zymosan-induced acute peritonitis. 
      FTA significantly alleviated peritonitis as evidenced by the decreased number of 
      neutrophils and levels of tumor necrosis factor alpha (TNF-alpha), interleukin-6 
      (IL-6), and monocyte chemoattractant protein-1 (MCP-1) in the peritoneal cavity, 
      without interfering with interleukin-10 (IL-10). FTA showed marked regulation of 
      inflammatory cytokines and chemokine levels in zymosan-stimulated RAW 264.7 
      macrophages. Moreover, FTA could suppress the activation of NF-kappaB. In conclusion, 
      FTA alleviated zymosan-induced acute peritonitis through inhibition of NF-kappaB 
      activation.
FAU - Zhang, Xiao-Tian
AU  - Zhang XT
AD  - School of Pharmacy, Shanghai University of Traditional Chinese Medicine, Shanghai 
      201203, China. zhangxt92@163.com.
FAU - Ding, Yue
AU  - Ding Y
AD  - School of Pharmacy, Shanghai University of Traditional Chinese Medicine, Shanghai 
      201203, China. dingyue-2001@hotmail.com.
FAU - Kang, Ping
AU  - Kang P
AD  - Headmaster's office, Shanghai University of Traditional Chinese Medicine, 
      Shanghai 201203, China. konnie1984@hotmail.com.
FAU - Zhang, Xin-Yu
AU  - Zhang XY
AD  - Experiment Center of Teaching & Learning, Shanghai University of Traditional 
      Chinese Medicine, Shanghai 201203, China. zhangxinyu319@hotmail.com.
FAU - Zhang, Tong
AU  - Zhang T
AD  - School of Pharmacy, Shanghai University of Traditional Chinese Medicine, Shanghai 
      201203, China. zhangtongshutcm@hotmail.com.
LA  - eng
PT  - Journal Article
DEP - 20180306
PL  - Switzerland
TA  - Molecules
JT  - Molecules (Basel, Switzerland)
JID - 100964009
RN  - 0 (Anti-Inflammatory Agents)
RN  - 0 (Cytokines)
RN  - 0 (Glycosides)
RN  - 0 (Inflammation Mediators)
RN  - 0 (NF-kappa B)
RN  - 9010-72-4 (Zymosan)
RN  - OUH5BQ893P (forsythiaside)
SB  - IM
MH  - Animals
MH  - Anti-Inflammatory Agents/pharmacology/*therapeutic use
MH  - Cytokines/metabolism
MH  - Glycosides/pharmacology/*therapeutic use
MH  - Inflammation Mediators/metabolism
MH  - Mice
MH  - NF-kappa B/metabolism
MH  - Neutrophils/drug effects
MH  - Peritoneal Cavity
MH  - Peritonitis/chemically induced/*drug therapy/immunology
MH  - RAW 264.7 Cells
MH  - Zymosan
PMC - PMC6017337
OTO - NOTNLM
OT  - forsythoside A
OT  - inflammation
OT  - peritonitis
OT  - zymosan
COIS- The authors declare no conflict of interest.
EDAT- 2018/03/07 06:00
MHDA- 2018/08/14 06:00
PMCR- 2018/03/06
CRDT- 2018/03/07 06:00
PHST- 2018/01/16 00:00 [received]
PHST- 2018/02/18 00:00 [revised]
PHST- 2018/02/19 00:00 [accepted]
PHST- 2018/03/07 06:00 [entrez]
PHST- 2018/03/07 06:00 [pubmed]
PHST- 2018/08/14 06:00 [medline]
PHST- 2018/03/06 00:00 [pmc-release]
AID - molecules23030593 [pii]
AID - molecules-23-00593 [pii]
AID - 10.3390/molecules23030593 [doi]
PST - epublish
SO  - Molecules. 2018 Mar 6;23(3):593. doi: 10.3390/molecules23030593.