PMID- 29510000
OWN - NLM
STAT- MEDLINE
DCOM- 20181026
LR  - 20221207
IS  - 1742-7843 (Electronic)
IS  - 1742-7835 (Linking)
VI  - 123
IP  - 3
DP  - 2018 Sep
TI  - Genetic Variations, Exposure to Persistent Organic Pollutants and Breast Cancer 
      Risk - A Greenlandic Case-Control Study.
PG  - 335-346
LID - 10.1111/bcpt.13002 [doi]
AB  - This study investigated the effects of single nucleotide polymorphisms (SNPs) in 
      xenobiotic and steroid hormone-metabolizing genes in relation to breast cancer 
      risk and explored possible effect modifications on persistent organic pollutants 
      (POPs) and breast cancer associations. The study also assessed effects of 
      Greenlandic BRCA1 founder mutations. Greenlandic Inuit women (77 cases and 84 
      controls) were included. We determined two founder mutations in BRCA1: Cys39Gly 
      (rs80357164) and 4684delCC, and five SNPs in xenobiotic and 
      oestrogen-metabolizing genes: CYP17A1 -34T>C (rs743572), CYP19A1 *19C>T 
      (rs10046), CYP1A1 Ile462Val (rs1048943), CYP1B Leu432Val (rs1056836) and COMT 
      Val158Met (rs4680). We used chi-square test for comparison of categorical 
      variables between groups. Odds ratio (OR) estimates with 95% confidence interval 
      (95%CI) were obtained using logistic regression models. The variant allele of 
      BRCA1 Cys39Gly increased breast cancer risk (Gly/Cys versus Cys/Cys, OR: 12.2, 
      95%CI: 1.53; 98.1), and carriers of the variant allele of CYP17A1 -34T>C had 
      reduced risk (CT+CC versus TT, OR: 0.44, 95%CI: 0.21; 0.93). CYP17A1 -34T>C was 
      an effect modifier on the association between perfluoroalkyl acids (PFAAs) and 
      breast cancer risk ( summation operatorPFAA, ratio of OR: 0.18, 95%CI: 0.03; 0.97). Non-significant 
      modifying tendencies were seen for the other SNPs on the effect of 
      polychlorinated biphenyls, organochlorine pesticides and PFAAs. In summary, the 
      BRCA1 Cys39Gly and CYP17A1 -34T>C genetic variations were associated with breast 
      cancer risk. Our results indicate that the evaluated genetic variants modify the 
      effects of POP exposure on breast cancer risk; however, further studies are 
      needed to document the data from the relatively small sample size.
CI  - (c) 2018 Nordic Association for the Publication of BCPT (former Nordic 
      Pharmacological Society).
FAU - Wielsoe, Maria
AU  - Wielsoe M
AD  - Centre for Arctic Health & Molecular Epidemiology, Aarhus University, Aarhus C, 
      Denmark.
FAU - Eiberg, Hans
AU  - Eiberg H
AD  - Department of Cellular and Molecular Medicine, University of Copenhagen, 
      Copenhagen, Denmark.
FAU - Ghisari, Mandana
AU  - Ghisari M
AD  - Centre for Arctic Health & Molecular Epidemiology, Aarhus University, Aarhus C, 
      Denmark.
FAU - Kern, Peder
AU  - Kern P
AD  - Department of Gynecology and Obstetrics, Dronning Ingrid's Hospital, Nuuk, 
      Greenland.
FAU - Lind, Ole
AU  - Lind O
AD  - Department of Gynecology and Obstetrics, Dronning Ingrid's Hospital, Nuuk, 
      Greenland.
FAU - Bonefeld-Jorgensen, Eva Cecilie
AU  - Bonefeld-Jorgensen EC
AD  - Centre for Arctic Health & Molecular Epidemiology, Aarhus University, Aarhus C, 
      Denmark.
AD  - Institute for Nursing and Health Science, Greenland's Center of Health Research, 
      University of Greenland, Nuuk, Greenland.
LA  - eng
SI  - GENBANK/NM_000102.3
SI  - GENBANK/NM_000103.3
SI  - GENBANK/NM_000499.4
SI  - GENBANK/NM_000104.3
SI  - GENBANK/NM_000754.3
SI  - GENBANK/NM_007294.3
PT  - Journal Article
DEP - 20180423
PL  - England
TA  - Basic Clin Pharmacol Toxicol
JT  - Basic & clinical pharmacology & toxicology
JID - 101208422
RN  - 0 (BRCA1 Protein)
RN  - 0 (BRCA1 protein, human)
RN  - 0 (Environmental Pollutants)
RN  - 9035-51-2 (Cytochrome P-450 Enzyme System)
SB  - IM
MH  - Adult
MH  - Aged
MH  - BRCA1 Protein/*genetics
MH  - Breast Neoplasms/*epidemiology/etiology/genetics
MH  - Case-Control Studies
MH  - Cytochrome P-450 Enzyme System/genetics
MH  - Environmental Exposure/*adverse effects
MH  - Environmental Pollutants/*toxicity
MH  - Female
MH  - Founder Effect
MH  - Genetic Predisposition to Disease
MH  - Genetic Variation
MH  - Greenland/epidemiology
MH  - Humans
MH  - Inuit
MH  - Logistic Models
MH  - Middle Aged
MH  - Mutation
MH  - Polymorphism, Single Nucleotide
MH  - Risk
EDAT- 2018/03/07 06:00
MHDA- 2018/10/27 06:00
CRDT- 2018/03/07 06:00
PHST- 2017/12/22 00:00 [received]
PHST- 2018/02/27 00:00 [accepted]
PHST- 2018/03/07 06:00 [pubmed]
PHST- 2018/10/27 06:00 [medline]
PHST- 2018/03/07 06:00 [entrez]
AID - 10.1111/bcpt.13002 [doi]
PST - ppublish
SO  - Basic Clin Pharmacol Toxicol. 2018 Sep;123(3):335-346. doi: 10.1111/bcpt.13002. 
      Epub 2018 Apr 23.