PMID- 29511378
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20201001
IS  - 1687-8760 (Print)
IS  - 1687-8779 (Electronic)
IS  - 1687-8760 (Linking)
VI  - 2018
DP  - 2018
TI  - Simultaneous Determination of Nitroimidazoles and Quinolones in Honey by Modified 
      QuEChERS and LC-MS/MS Analysis.
PG  - 4271385
LID - 10.1155/2018/4271385 [doi]
LID - 4271385
AB  - This study reports an analytical method for the determination of nitroimidazole 
      and quinolones in honey using liquid chromatography-tandem mass spectrometry 
      (LC-MS/MS). A modified QuEChERS methodology was used to extract the analytes and 
      determine veterinary drugs in honey by LC-MS/MS. The linear regression was 
      excellent at the concentration levels of 1-100 ng/mL in the solution standard 
      curve and the matrix standard curve. The recovery rates of nitroimidazole and 
      quinolones were 4.4% to 59.1% and 9.8% to 46.2% with relative standard deviations 
      (RSDs) below 5.2% and the recovery rates of nitroimidazole and quinolones by the 
      matrix standard curve ranged from 82.0% to 117.8% and 79% to 115.9% with relative 
      standard deviations (RSDs) lower than 6.3% in acacia and jujube honey. The acacia 
      and jujube honeys have stronger matrix inhibition effect to nitroimidazole and 
      quinolones residue; the matrix inhibition effect of jujube honey is stronger than 
      acacia honey. The matrix standard curve can calibrate matrix effect effectively. 
      In this study, the detection method of antibiotics in honey can be applied to the 
      actual sample. The results demonstrated that the modified QuEChERS method 
      combined with LC-MS/MS is a rapid, high, sensitive method for the analysis of 
      nitroimidazoles and quinolones residues in honey.
FAU - Lei, Haiyan
AU  - Lei H
AD  - Department of Food Science and Engineering, School of Chemical Engineering, 
      Northwest University, Xi'an, Shaanxi 710069, China.
FAU - Guo, Jianbo
AU  - Guo J
AD  - Shaanxi Institute for Food and Drug Control, Xi'an, Shaanxi 710069, China.
FAU - Lv, Zhuo
AU  - Lv Z
AD  - Shaanxi Institute for Food and Drug Control, Xi'an, Shaanxi 710069, China.
FAU - Zhu, Xiaohong
AU  - Zhu X
AD  - Shaanxi Institute for Food and Drug Control, Xi'an, Shaanxi 710069, China.
FAU - Xue, Xiaofeng
AU  - Xue X
AD  - Institute of Apiculture Research, Chinese Academy of Agricultural Sciences, 
      Beijing 100093, China.
FAU - Wu, Liming
AU  - Wu L
AD  - Institute of Apiculture Research, Chinese Academy of Agricultural Sciences, 
      Beijing 100093, China.
FAU - Cao, Wei
AU  - Cao W
AUID- ORCID: 0000-0001-9615-3754
AD  - Department of Food Science and Engineering, School of Chemical Engineering, 
      Northwest University, Xi'an, Shaanxi 710069, China.
LA  - eng
PT  - Journal Article
DEP - 20180101
PL  - Egypt
TA  - Int J Anal Chem
JT  - International journal of analytical chemistry
JID - 101519424
PMC - PMC5817847
EDAT- 2018/03/08 06:00
MHDA- 2018/03/08 06:01
PMCR- 2018/01/01
CRDT- 2018/03/08 06:00
PHST- 2017/09/02 00:00 [received]
PHST- 2017/10/25 00:00 [revised]
PHST- 2017/11/20 00:00 [accepted]
PHST- 2018/03/08 06:00 [entrez]
PHST- 2018/03/08 06:00 [pubmed]
PHST- 2018/03/08 06:01 [medline]
PHST- 2018/01/01 00:00 [pmc-release]
AID - 10.1155/2018/4271385 [doi]
PST - epublish
SO  - Int J Anal Chem. 2018 Jan 1;2018:4271385. doi: 10.1155/2018/4271385. eCollection 
      2018.