PMID- 29511452
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20201001
IS  - 1943-8141 (Print)
IS  - 1943-8141 (Electronic)
IS  - 1943-8141 (Linking)
VI  - 10
IP  - 2
DP  - 2018
TI  - Expression of long non-coding RNA HOXA11-AS is correlated with progression of 
      laryngeal squamous cell carcinoma.
PG  - 573-580
AB  - Long noncoding RNA HOXA11 antisense RNA (HOXA11-AS) is involved in tumorigenesis 
      and development of some human cancers. However, the role of HOXA11-AS in human 
      laryngeal squamous cell cancer (LSCC) is yet unclear. In this study, we firstly 
      investigated the expression of HOXA11-AS in LSCC. Microarray and qRT-PCR showed 
      that the level of HOXA11-AS was significantly higher in LSCC than that in the 
      corresponding adjacent non-neoplastic tissues. ISH revealed that HOXA11-AS was 
      strongly expressed in the nucleus and closely related to the T grade, neck nodal 
      metastasis, and clinical stage. Patients with T3-4 grade, neck nodal metastasis, 
      or advanced clinical stage presented a high HOXA11-AS expression. Kaplan-Meier 
      analysis showed that high HOXA11-AS expression could predict a poor prognosis in 
      LSCC patients. Furthermore, HOXA11-AS knockdown significantly inhibited the 
      growth, migration, and invasion of LSCC cells. Taken together, the current data 
      indicated that HOXA11-AS plays an oncogenic role in the cellular processes of 
      LSCC and serve as a novel marker and a potential therapeutic target in LSCC 
      patients.
FAU - Qu, Lingmei
AU  - Qu L
AD  - Department of Otorhinolaryngology, Head and Neck Surgery, The Fifth Affiliated 
      Hospital, Harbin Medical UniversityDaqing 163316, China.
AD  - Department of Otorhinolaryngology, Head and Neck Surgery, The Second Affiliated 
      Hospital, Harbin Medical UniversityHarbin 150086, China.
FAU - Jin, Meng
AU  - Jin M
AD  - Department of Otorhinolaryngology, Head and Neck Surgery, The Second Affiliated 
      Hospital, Harbin Medical UniversityHarbin 150086, China.
FAU - Yang, Like
AU  - Yang L
AD  - Department of Otorhinolaryngology, Head and Neck Surgery, The Second Affiliated 
      Hospital, Harbin Medical UniversityHarbin 150086, China.
FAU - Sun, Chuanhui
AU  - Sun C
AD  - Department of Otorhinolaryngology, Head and Neck Surgery, The Second Affiliated 
      Hospital, Harbin Medical UniversityHarbin 150086, China.
FAU - Wang, Peng
AU  - Wang P
AD  - Department of Otorhinolaryngology, Head and Neck Surgery, The Second Affiliated 
      Hospital, Harbin Medical UniversityHarbin 150086, China.
FAU - Li, Yushan
AU  - Li Y
AD  - Department of Otorhinolaryngology, Head and Neck Surgery, The Second Affiliated 
      Hospital, Harbin Medical UniversityHarbin 150086, China.
FAU - Tian, Linli
AU  - Tian L
AD  - Department of Otorhinolaryngology, Head and Neck Surgery, The Second Affiliated 
      Hospital, Harbin Medical UniversityHarbin 150086, China.
FAU - Liu, Ming
AU  - Liu M
AD  - Department of Otorhinolaryngology, Head and Neck Surgery, The Second Affiliated 
      Hospital, Harbin Medical UniversityHarbin 150086, China.
FAU - Sun, Yanan
AU  - Sun Y
AD  - Department of Otorhinolaryngology, Head and Neck Surgery, The Second Affiliated 
      Hospital, Harbin Medical UniversityHarbin 150086, China.
LA  - eng
PT  - Journal Article
DEP - 20180215
PL  - United States
TA  - Am J Transl Res
JT  - American journal of translational research
JID - 101493030
PMC - PMC5835823
OTO - NOTNLM
OT  - HOXA11-AS
OT  - Laryngeal squamous cell cancer (LSCC)
OT  - long noncoding RNA
OT  - prognosis
COIS- None.
EDAT- 2018/03/08 06:00
MHDA- 2018/03/08 06:01
PMCR- 2018/02/15
CRDT- 2018/03/08 06:00
PHST- 2017/11/12 00:00 [received]
PHST- 2018/01/22 00:00 [accepted]
PHST- 2018/03/08 06:00 [entrez]
PHST- 2018/03/08 06:00 [pubmed]
PHST- 2018/03/08 06:01 [medline]
PHST- 2018/02/15 00:00 [pmc-release]
PST - epublish
SO  - Am J Transl Res. 2018 Feb 15;10(2):573-580. eCollection 2018.