PMID- 29511593 OWN - NLM STAT- PubMed-not-MEDLINE LR - 20240313 IS - 2156-6976 (Print) IS - 2156-6976 (Electronic) IS - 2156-6976 (Linking) VI - 8 IP - 2 DP - 2018 TI - Next generation sequencing-based emerging trends in molecular biology of gastric cancer. PG - 207-225 AB - Gastric cancer (GC) is one of the leading causes of cancer related mortality in the world. Being asymptomatic in nature till advanced stage, diagnosis of gastric cancer becomes difficult in early stages of the disease. The onset and progression of gastric cancer has been attributed to multiple factors including genetic alterations, epigenetic modifications, Helicobacter pylori and Epstein-Barr Virus (EBV) infection, and dietary habits. Next Generation Sequencing (NGS) based approaches viz. Whole Genome Sequencing (WGS), Whole Exome Sequencing (WES), RNA-Seq, and targeted sequencing have expanded the knowledge base of molecular pathogenesis of gastric cancer. In this review, we highlight recent NGS-based advances covering various genetic alterations (Microsatellite Instability, Single Nucleotide Variations, and Copy Number Variations), epigenetic changes (DNA methylation, histone modification, microRNAs) and differential gene expression during gastric tumorigenesis. We also briefly discuss the current and future potential biomarkers, drugs and therapeutic approaches available for the management of gastric cancer. FAU - Verma, Renu AU - Verma R AD - University School of Biotechnology, Guru Gobind Singh Indraprastha UniversityNew Delhi 110078, India. FAU - Sharma, Prakash C AU - Sharma PC AD - University School of Biotechnology, Guru Gobind Singh Indraprastha UniversityNew Delhi 110078, India. LA - eng PT - Journal Article PT - Review DEP - 20180201 PL - United States TA - Am J Cancer Res JT - American journal of cancer research JID - 101549944 PMC - PMC5835690 OTO - NOTNLM OT - Gastric cancer OT - differential gene expression OT - epigenetic modifications OT - microsatellite instability (MSI) OT - next generation sequencing (NGS) OT - single nucleotide variations (SNVs) COIS- None. EDAT- 2018/03/08 06:00 MHDA- 2018/03/08 06:01 PMCR- 2018/02/01 CRDT- 2018/03/08 06:00 PHST- 2017/11/21 00:00 [received] PHST- 2017/11/29 00:00 [accepted] PHST- 2018/03/08 06:00 [entrez] PHST- 2018/03/08 06:00 [pubmed] PHST- 2018/03/08 06:01 [medline] PHST- 2018/02/01 00:00 [pmc-release] PST - epublish SO - Am J Cancer Res. 2018 Feb 1;8(2):207-225. eCollection 2018.