PMID- 29511802
OWN - NLM
STAT- MEDLINE
DCOM- 20190319
LR  - 20190319
IS  - 1433-8726 (Electronic)
IS  - 0724-4983 (Linking)
VI  - 36
IP  - 8
DP  - 2018 Aug
TI  - Effects of testosterone supplement treatment in hypogonadal adult males with 
      T2DM: a meta-analysis and systematic review.
PG  - 1315-1326
LID - 10.1007/s00345-018-2256-0 [doi]
AB  - PURPOSE: Testosterone supplement treatment (TST) is a classic therapy for 
      hypogonadal men with type 2 diabetes mellitus (T2DM), but the effects of TST in 
      different studies are inconsistent. We conducted this meta-analysis to evaluate 
      the precise role of TST in hypogonadal men with T2DM. METHODS: PubMed, Embase, 
      Cochrane Library and Web of Science were searched to identify qualified 
      randomized controlled trials (RCTs). Pooled mean differences (MDs) with 95% 
      confidence intervals (CIs) were calculated to measure the specific effects of 
      TST. Trial sequential analysis was performed to verify the pooled results. 
      RESULTS: A total of eight RCTs were enrolled in our meta-analysis, including 596 
      hypogonadal participants with T2DM. Compared with comparators, TST can 
      significantly improve glycemic control by reducing homeostatic model assessment 
      of insulin resistance (MD - 0.79, 95% CI - 1.23 to - 0.34), fasting glucose (MD - 
      0.98, 95% CI - 1.13 to - 0.54), fasting insulin (MD - 2.47, 95% CI - 3.99 to - 
      0.95) and HbA1c% (MD - 0.45, 95% CI - 0.73 to - 0.16). In addition, TST can 
      result in a decline in cholesterol (MD - 0.29, 95% CI - 0.38 to - 0.19) and 
      triglyceride (MD - 0.37, 95% CI - 0.59 to - 0.15). CONCLUSION: Our results 
      indicated that TST can improve glycemic control and decrease TC and TG in 
      hypogonadal patients with T2DM. We recommend TST during the anti-diabetic therapy 
      in these patients.
FAU - Zhang, Jianzhong
AU  - Zhang J
AD  - Department of Urology, Peking Union Medical College Hospital, Peking Union 
      Medical College, Chinese Academy of Medical Sciences, Beijing, 100730, China.
FAU - Yang, Bin
AU  - Yang B
AD  - Department of Urology, Peking Union Medical College Hospital, Peking Union 
      Medical College, Chinese Academy of Medical Sciences, Beijing, 100730, China.
FAU - Xiao, Wenhui
AU  - Xiao W
AD  - The Fourth Clinical Medical College, Institute of Medicine and Nursing Hubei 
      University of Medicine, Shiyan, 442000, China.
FAU - Li, Xiao
AU  - Li X
AD  - Department of Urology, The Affiliated Cancer Hospital of Jiangsu Province of 
      Nanjing Medical University, Nanjing, 210009, China.
FAU - Li, Hongjun
AU  - Li H
AUID- ORCID: 0000-0001-6040-5251
AD  - Department of Urology, Peking Union Medical College Hospital, Peking Union 
      Medical College, Chinese Academy of Medical Sciences, Beijing, 100730, China. 
      lihongjun@pumch.cn.
LA  - eng
GR  - 81370698/National Natural Science Foundation of China/
GR  - 81671488/National Natural Science Foundation of China/
GR  - 7162152/Beijing Municipal Natural Science Foundation/
PT  - Journal Article
PT  - Meta-Analysis
PT  - Systematic Review
DEP - 20180306
PL  - Germany
TA  - World J Urol
JT  - World journal of urology
JID - 8307716
RN  - 0 (Androgens)
RN  - 0 (Blood Glucose)
RN  - 0 (Insulin)
RN  - 3XMK78S47O (Testosterone)
SB  - IM
MH  - Adult
MH  - Androgens/*therapeutic use
MH  - Blood Glucose/metabolism
MH  - Confidence Intervals
MH  - Diabetes Mellitus, Type 2/*complications/metabolism
MH  - Humans
MH  - Hypogonadism/complications/*drug therapy/metabolism
MH  - Insulin
MH  - Male
MH  - Middle Aged
MH  - Randomized Controlled Trials as Topic
MH  - Testosterone/*therapeutic use
OTO - NOTNLM
OT  - Glucose
OT  - Lipid
OT  - Metabolism
OT  - T2DM
OT  - TST
EDAT- 2018/03/08 06:00
MHDA- 2019/03/20 06:00
CRDT- 2018/03/08 06:00
PHST- 2018/01/27 00:00 [received]
PHST- 2018/02/28 00:00 [accepted]
PHST- 2018/03/08 06:00 [pubmed]
PHST- 2019/03/20 06:00 [medline]
PHST- 2018/03/08 06:00 [entrez]
AID - 10.1007/s00345-018-2256-0 [pii]
AID - 10.1007/s00345-018-2256-0 [doi]
PST - ppublish
SO  - World J Urol. 2018 Aug;36(8):1315-1326. doi: 10.1007/s00345-018-2256-0. Epub 2018 
      Mar 6.