PMID- 29511890
OWN - NLM
STAT- MEDLINE
DCOM- 20191002
LR  - 20191002
IS  - 1432-198X (Electronic)
IS  - 0931-041X (Linking)
VI  - 33
IP  - 7
DP  - 2018 Jul
TI  - Urinary clusterin-a novel urinary biomarker associated with pediatric lupus renal 
      histopathologic features and renal survival.
PG  - 1189-1198
LID - 10.1007/s00467-018-3924-4 [doi]
AB  - BACKGROUND: Lupus nephritis (LN) is a major risk factor for systemic lupus 
      erythematous (SLE)-related morbidity and mortality. With the aim of bypassing 
      renal biopsy, we analyzed urinary biomarkers for their ability to predict renal 
      histopathologic features and end-stage kidney disease (ESKD). METHODS: Urinary 
      albumin, ss2-microglobulin (B2M), cystatin C, kidney injury molecule-1 (KIM-1), 
      monocyte chemoattractant protein 1 (MCP-1), clusterin, calbindin, interleukin-18 
      (IL-18), neutrophil gelatinase-associated lipocalin (NGAL), trefoil factor 3 
      (TFF3), osteopontin, and glutathione S-transferase pi (GST-pi) levels were measured 
      at time of renal biopsy. Renal histopathologies were carefully reviewed. RESULTS: 
      Urine from 60 pediatric SLE cases with LN, 29 without and 22 healthy controls 
      were collected. Median age at SLE diagnosis was 12.92 years 
      (range = 4.27-17.30 years) and 10 cases progressed to ESKD during a period of 
      4.12 +/- 2.17 years. Urinary albumin and clusterin were significantly elevated 
      (p = 0.035 and 0.048, respectively) in patients with tubulointerstitial renal 
      lesions. Urinary clusterin among all urinary markers, performed best at 
      predicting ESKD with cutoff of 0.61 x 10(-4) (AUC = 0.804; p = 0.002). 
      Interestingly, elevation of urinary clusterin likely resulted from local 
      over-expression in tubulointerstitial tissue since the level of serum clusterin 
      was not concomitantly higher (p = 0.424). CONCLUSION: Urinary biomarkers are 
      emerging as non-invasive indicators for lupus-related renal histopathology and 
      renal outcome prediction in pediatric SLE patients. Urinary clusterin, a newly 
      identified biomarker, is an indicator that shows an association with 
      tubulointerstitial renal lesions and demonstrates the best ability to predict 
      ESKD.
FAU - Wu, Chao-Yi
AU  - Wu CY
AD  - Division of Allergy, Asthma, and Rheumatology, Department of Pediatrics, Chang 
      Gung Memorial Hospital Linko branch, Taoyuan, Taiwan.
AD  - Chang Gung University, College of Medicine, Taoyuan, Taiwan.
FAU - Yang, Huang-Yu
AU  - Yang HY
AD  - Chang Gung University, College of Medicine, Taoyuan, Taiwan.
AD  - Department of Nephrology, Chang Gung Memorial Hospital Linko branch, Taoyuan, 
      Taiwan.
FAU - Chien, Hui-Ping
AU  - Chien HP
AD  - Chang Gung University, College of Medicine, Taoyuan, Taiwan.
AD  - Department of Pathology, Chang Gung Memorial Hospital Linko branch, Taoyuan, 
      Taiwan.
FAU - Tseng, Min-Hua
AU  - Tseng MH
AD  - Chang Gung University, College of Medicine, Taoyuan, Taiwan.
AD  - Division of Pediatric Nephrology, Department of Pediatrics, Chang Gung Memorial 
      Hospital Linko branch, Taoyuan, Taiwan.
FAU - Huang, Jing-Long
AU  - Huang JL
AD  - Division of Allergy, Asthma, and Rheumatology, Department of Pediatrics, Chang 
      Gung Memorial Hospital Linko branch, Taoyuan, Taiwan. long@adm.cgmh.org.tw.
AD  - Chang Gung University, College of Medicine, Taoyuan, Taiwan. 
      long@adm.cgmh.org.tw.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20180306
PL  - Germany
TA  - Pediatr Nephrol
JT  - Pediatric nephrology (Berlin, Germany)
JID - 8708728
RN  - 0 (Biomarkers)
RN  - 0 (CLU protein, human)
RN  - 0 (Clusterin)
SB  - IM
MH  - Adolescent
MH  - Biomarkers/urine
MH  - Biopsy
MH  - Child
MH  - Child, Preschool
MH  - Clusterin/blood/metabolism/*urine
MH  - Disease Progression
MH  - Female
MH  - Follow-Up Studies
MH  - Humans
MH  - Kidney Failure, Chronic/blood/*diagnosis/pathology
MH  - Kidney Tubules/metabolism/*pathology
MH  - Lupus Nephritis/blood/*complications/urine
MH  - Male
MH  - Nephritis, Interstitial/blood/etiology/pathology/*urine
MH  - Predictive Value of Tests
MH  - Prognosis
MH  - Retrospective Studies
OTO - NOTNLM
OT  - Clusterin
OT  - End-stage kidney disease
OT  - Lupus nephritis
OT  - Pediatric onset systemic lupus erythematosus
OT  - Tubulointerstitial renal lesion
OT  - Urinary biomarkers
EDAT- 2018/03/08 06:00
MHDA- 2019/10/03 06:00
CRDT- 2018/03/08 06:00
PHST- 2017/09/25 00:00 [received]
PHST- 2018/01/30 00:00 [accepted]
PHST- 2018/01/29 00:00 [revised]
PHST- 2018/03/08 06:00 [pubmed]
PHST- 2019/10/03 06:00 [medline]
PHST- 2018/03/08 06:00 [entrez]
AID - 10.1007/s00467-018-3924-4 [pii]
AID - 10.1007/s00467-018-3924-4 [doi]
PST - ppublish
SO  - Pediatr Nephrol. 2018 Jul;33(7):1189-1198. doi: 10.1007/s00467-018-3924-4. Epub 
      2018 Mar 6.