PMID- 29512923
OWN - NLM
STAT- MEDLINE
DCOM- 20191023
LR  - 20210109
IS  - 1582-4934 (Electronic)
IS  - 1582-1838 (Print)
IS  - 1582-1838 (Linking)
VI  - 22
IP  - 5
DP  - 2018 May
TI  - Modulation of the oxidative plasmatic state in gastroesophageal reflux disease 
      with the addition of rich water molecular hydrogen: A new biological vision.
PG  - 2750-2759
LID - 10.1111/jcmm.13569 [doi]
AB  - Gastroesophageal reflux disease (GERD), a clinical condition characterized by 
      reflux of gastroduodenal contents in the oesophagus, has proved to demonstrate a 
      strong link between oxidative stress and the development of GERD. Proton pump 
      inhibitors (PPIs) have been universally accepted as first-line therapy for 
      management of GERD. The potential benefits of electrolysed reduced water (ERW), 
      rich in molecular hydrogen, in improving symptoms and systemic oxidative stress 
      associated with GERD was assessed. The study was performed on 84 GERD patients 
      undergoing control treatment (PPI + tap water) or experimental treatment (PPI + 
      ERW) for 3 months. These patients were subjected to the GERD-Health Related 
      Quality of Life Questionnaire as well as derivatives reactive oxigen metabolites 
      (d-ROMs) test, biological antioxidant potential (BAP) test, superoxide anion, 
      nitric oxide and malondialdehyde assays, which were all performed as a proxy for 
      the oxidative/nitrosative stress and the antioxidant potential status. Spearman's 
      correlation coefficient was used to evaluate the correlation between scores and 
      laboratory parameters. Overall results demonstrated that an optimal oxidative 
      balance can be restored and GERD symptoms can be reduced rapidly via the 
      integration of ERW in GERD patients. The relative variation of heartburn and 
      regurgitation score was significantly correlated with laboratory parameters. 
      Thus, in the selected patients, combination treatment with PPI and ERW improves 
      the cellular redox state leading to the improvement of the quality of life as 
      demonstrated by the correlation analysis between laboratory parameters and GERD 
      symptoms.
CI  - (c) 2018 The Authors. Journal of Cellular and Molecular Medicine published by John 
      Wiley & Sons Ltd and Foundation for Cellular and Molecular Medicine.
FAU - Franceschelli, Sara
AU  - Franceschelli S
AD  - Department of Medicine and Science of Aging, University "G. D' Annunzio", Chieti, 
      Italy.
FAU - Gatta, Daniela Maria Pia
AU  - Gatta DMP
AD  - Department of Medicine and Science of Aging, University "G. D' Annunzio", Chieti, 
      Italy.
FAU - Pesce, Mirko
AU  - Pesce M
AD  - Department of Psychological, Health and Territorial Sciences, University "G. D' 
      Annunzio", Chieti, Italy.
FAU - Ferrone, Alessio
AU  - Ferrone A
AD  - Department of Medicine and Science of Aging, University "G. D' Annunzio", Chieti, 
      Italy.
FAU - Di Martino, Giuseppe
AU  - Di Martino G
AD  - Laboratory of Biostatistics, Department of Medical, Oral and Biotechnological 
      Sciences, University "G. D' Annunzio", Chieti, Italy.
FAU - Di Nicola, Marta
AU  - Di Nicola M
AD  - Laboratory of Biostatistics, Department of Medical, Oral and Biotechnological 
      Sciences, University "G. D' Annunzio", Chieti, Italy.
FAU - De Lutiis, Maria Anna
AU  - De Lutiis MA
AD  - Department of Medicine and Science of Aging, University "G. D' Annunzio", Chieti, 
      Italy.
FAU - Vitacolonna, Ester
AU  - Vitacolonna E
AD  - Department of Medicine and Science of Aging, University "G. D' Annunzio", Chieti, 
      Italy.
FAU - Patruno, Antonia
AU  - Patruno A
AD  - Department of Medicine and Science of Aging, University "G. D' Annunzio", Chieti, 
      Italy.
FAU - Grilli, Alfredo
AU  - Grilli A
AD  - Department of Psychological, Health and Territorial Sciences, University "G. D' 
      Annunzio", Chieti, Italy.
FAU - Felaco, Mario
AU  - Felaco M
AD  - Department of Medicine and Science of Aging, University "G. D' Annunzio", Chieti, 
      Italy.
FAU - Speranza, Lorenza
AU  - Speranza L
AUID- ORCID: 0000-0002-7024-3257
AD  - Department of Medicine and Science of Aging, University "G. D' Annunzio", Chieti, 
      Italy.
LA  - eng
PT  - Clinical Trial
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20180307
PL  - England
TA  - J Cell Mol Med
JT  - Journal of cellular and molecular medicine
JID - 101083777
RN  - 0 (Antioxidants)
RN  - 0 (Proton Pump Inhibitors)
RN  - 059QF0KO0R (Water)
RN  - 7YNJ3PO35Z (Hydrogen)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Antioxidants/metabolism
MH  - Gastroesophageal Reflux/*blood/*therapy
MH  - Humans
MH  - Hydrogen/*therapeutic use
MH  - Middle Aged
MH  - Oxidation-Reduction
MH  - Oxidative Stress/drug effects
MH  - Proton Pump Inhibitors/therapeutic use
MH  - Quality of Life
MH  - Water/*pharmacology
MH  - Young Adult
PMC - PMC5908129
OTO - NOTNLM
OT  - electrolysed reduced water
OT  - gastroesophageal reflux disease
OT  - molecular hydrogen
OT  - nitric oxide
OT  - oxidative stress
OT  - proton pump inhibitors
EDAT- 2018/03/08 06:00
MHDA- 2019/10/24 06:00
PMCR- 2018/05/01
CRDT- 2018/03/08 06:00
PHST- 2017/08/31 00:00 [received]
PHST- 2017/12/22 00:00 [accepted]
PHST- 2018/03/08 06:00 [pubmed]
PHST- 2019/10/24 06:00 [medline]
PHST- 2018/03/08 06:00 [entrez]
PHST- 2018/05/01 00:00 [pmc-release]
AID - JCMM13569 [pii]
AID - 10.1111/jcmm.13569 [doi]
PST - ppublish
SO  - J Cell Mol Med. 2018 May;22(5):2750-2759. doi: 10.1111/jcmm.13569. Epub 2018 Mar 
      7.