PMID- 29513385
OWN - NLM
STAT- Publisher
LR  - 20240227
IS  - 1531-4995 (Electronic)
IS  - 0023-852X (Linking)
DP  - 2018 Mar 7
TI  - Quality-of-Life Metrics Correlate With Disease Severity in Idiopathic Subglottic 
      Stenosis.
LID - 10.1002/lary.26930 [doi]
AB  - OBJECTIVES: Idiopathic subglottic stenosis (ISGS) can have significant impacts on 
      quality of life (QOL), but it remains unclear how patients' subjective responses 
      correlate with objective measurement of disease severity. Peak expiratory flow 
      percentage (PEF%) has been shown to be an effective measure of disease severity 
      in subglottic stenosis. This study aims to identify the key QOL questions 
      correlated with PEF% and proposes a statistical model for prediction of disease 
      severity. METHODS: Patients with ISGS presenting to an academic laryngologist 
      were included retrospectively from 2012 to 2016. Peak expiratory flow percentage 
      (age, sex, and height adjusted) was recorded for each visit, along with four 
      validated QOL instruments (European QOL-Five Dimensions; RAND 36-Item Health 
      Survey; Clinical COPD [Chronic Obstructive Pulmonary Disease] Questionnaire; and 
      the Airway, Dyspnea, Voice, and Swallowing Summary Assessment). A stepwise 
      multiple linear regression was used to identify statistically significant 
      independent variables correlated with PEF%, and a model was built with these 
      variables. RESULTS: Thirty-two patients were included, with a total of 271 
      patient encounters. Overall scores from each of the four QOL instruments were 
      correlated with PEF% values recorded each visit (P < 0.05). Question responses 
      correlating most positively included overall breathlessness, difficulty catching 
      breath, cough within the past week, dyspnea with moderate activity, perception 
      that voice changes are restricting social life, and overall general health (all 
      P < 0.01). A model constructed using six nonoverlapping questions yielded an 
      adjusted R(2) of 0.58. CONCLUSION: Quality of life is correlated to PEF% in ISGS. 
      Using a limited number of QOL questions, clinicians can predict objective 
      worsening or improvement of disease severity, as measured by spirometry. LEVEL OF 
      EVIDENCE: 2b. Laryngoscope, 2017.
CI  - (c) 2017 The American Laryngological, Rhinological and Otological Society, Inc.
FAU - Naunheim, Matthew R
AU  - Naunheim MR
AUID- ORCID: 0000-0002-3927-3984
AD  - Department of Otolaryngology-Head and Neck Surgery, Massachusetts Eye and Ear 
      Infirmary, Boston, Massachusetts.
AD  - Department of Otolaryngology, Harvard Medical School, Boston, Massachusetts.
FAU - Paddle, Paul M
AU  - Paddle PM
AD  - Department of Otolaryngology-Head and Neck Surgery, Massachusetts Eye and Ear 
      Infirmary, Boston, Massachusetts.
AD  - Melbourne ENT Group, Melbourne, Australia.
FAU - Husain, Inna
AU  - Husain I
AD  - Department of Otorhinolaryngology, Rush Medical College, Chicago, Illinois, 
      U.S.A.
FAU - Wangchalabovorn, Patcharamanee
AU  - Wangchalabovorn P
AD  - Department of Otolaryngology, Harvard Medical School, Boston, Massachusetts.
FAU - Rosario, David
AU  - Rosario D
AD  - Department of Otolaryngology-Head and Neck Surgery, Massachusetts Eye and Ear 
      Infirmary, Boston, Massachusetts.
AD  - Department of Otolaryngology, Harvard Medical School, Boston, Massachusetts.
FAU - Franco, Ramon A Jr
AU  - Franco RA Jr
AUID- ORCID: 0000-0002-4549-6017
AD  - Department of Otolaryngology-Head and Neck Surgery, Massachusetts Eye and Ear 
      Infirmary, Boston, Massachusetts.
AD  - Department of Otolaryngology, Harvard Medical School, Boston, Massachusetts.
LA  - eng
PT  - Journal Article
DEP - 20180307
PL  - United States
TA  - Laryngoscope
JT  - The Laryngoscope
JID - 8607378
OTO - NOTNLM
OT  - Outcomes research
OT  - PFTs
OT  - PROMs
OT  - patient-reported outcomes measures
OT  - quality-of-life
OT  - subglottic stenosis
OT  - tracheal stenosis
EDAT- 2018/03/08 06:00
MHDA- 2018/03/08 06:00
CRDT- 2018/03/08 06:00
PHST- 2017/04/07 00:00 [received]
PHST- 2017/08/01 00:00 [revised]
PHST- 2017/08/22 00:00 [accepted]
PHST- 2018/03/08 06:00 [entrez]
PHST- 2018/03/08 06:00 [pubmed]
PHST- 2018/03/08 06:00 [medline]
AID - 10.1002/lary.26930 [doi]
PST - aheadofprint
SO  - Laryngoscope. 2018 Mar 7. doi: 10.1002/lary.26930.