PMID- 29513933
OWN - NLM
STAT- MEDLINE
DCOM- 20190510
LR  - 20190510
IS  - 1615-9861 (Electronic)
IS  - 1615-9853 (Linking)
VI  - 18
IP  - 12
DP  - 2018 Jun
TI  - Gaining Insight Into Posttranslationally Modified HIV Antigens and Their 
      Underlying Characteristics.
PG  - e1800041
LID - 10.1002/pmic.201800041 [doi]
AB  - Mass spectrometry (MS)-based immunopeptidomics has developed as one of the 
      leading methodologies for comprehensive characterization of in vivo presented 
      human leukocyte antigen (HLA)-bound peptides. Unveiling the identity of HLA-bound 
      peptides derived from diseased cells is crucial to gain knowledge on the 
      constitution of efficient disease-specific T cell responses. The HLA-presented 
      peptidome reflects the status of the cellular proteome, hence disease-related 
      aberrations of posttranslational modifications (PTMs) might lead to presentation 
      of peptides harboring PTMs. Therefore, characterization of HLA-bound PTM peptides 
      could shed light on their relevance in immune and disease processes. In this 
      issue, Ramarathinam et al. investigate the presentation of HIV envelope (HIVenv) 
      peptides bound to the HLA-B*57:01 allele. Among these peptides, the authors 
      specifically focused on a kynurenine-modified peptide. To this end, they 
      characterize the possible origin of the kynurenine modification, its effect on 
      HLA binding affinity, stability, conformation within the complex, and its 
      immunogenicity compared to the native counterpart.
CI  - (c) 2018 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
FAU - Marino, Fabio
AU  - Marino F
AUID- ORCID: 0000-0003-4211-5685
AD  - Departement de Medecine-Oncology, Centre Hospitalier Universitaire Vaudois, 
      Switzerland.
LA  - eng
PT  - Comment
PT  - Journal Article
DEP - 20180414
PL  - Germany
TA  - Proteomics
JT  - Proteomics
JID - 101092707
RN  - 0 (Epitopes)
RN  - 0 (HIV Antigens)
RN  - 0 (HLA-B Antigens)
RN  - 0 (HLA-B57 antigen)
SB  - IM
CON - Proteomics. 2018 Jun;18(12):e1700253. PMID: 29437277
MH  - *Antigen Presentation
MH  - Epitopes
MH  - HIV
MH  - *HIV Antigens
MH  - HLA-B Antigens
MH  - Humans
OTO - NOTNLM
OT  - HIV
OT  - HLA-B*57:01
OT  - Immunopeptidomics
OT  - Kynurenine
EDAT- 2018/03/08 06:00
MHDA- 2019/05/11 06:00
CRDT- 2018/03/08 06:00
PHST- 2018/02/16 00:00 [received]
PHST- 2018/02/16 00:00 [revised]
PHST- 2018/03/08 06:00 [pubmed]
PHST- 2019/05/11 06:00 [medline]
PHST- 2018/03/08 06:00 [entrez]
AID - 10.1002/pmic.201800041 [doi]
PST - ppublish
SO  - Proteomics. 2018 Jun;18(12):e1800041. doi: 10.1002/pmic.201800041. Epub 2018 Apr 
      14.