PMID- 29514658
OWN - NLM
STAT- MEDLINE
DCOM- 20181213
LR  - 20240213
IS  - 1471-2350 (Electronic)
IS  - 1471-2350 (Linking)
VI  - 19
IP  - 1
DP  - 2018 Mar 7
TI  - Meta-analysis of association between TCF7L2 polymorphism rs7903146 and type 2 
      diabetes mellitus.
PG  - 38
LID - 10.1186/s12881-018-0553-5 [doi]
LID - 38
AB  - BACKGROUND: Large scale association studies have found a significant association 
      between type 2 diabetes mellitus (T2DM) and transcription factor 7-like 2 
      (TCF7L2) polymorphism rs7903146. However, the quality of data varies greatly, as 
      the studies report inconsistent results in different populations. Hence, we 
      perform this meta-analysis to give a more convincing result. METHODS: The 
      articles, published from January 1st, 2000 to April 1st, 2017, were identified by 
      searching in PubMed and Google Scholar. A total of 56628 participants (34232 
      cases and 22396 controls) were included in the meta-analysis. A total of 28 
      studies were divided into 4 subgroups: Caucasian (10 studies), East Asian (5 
      studies), South Asian (5 studies) and Others (8 studies). All the data analyses 
      were analyzed by the R package meta. RESULTS: The significant association was 
      observed by using the dominant model (OR = 1.41, CI = 1.36 - 1.47, p < 0.0001), 
      recessive model (OR = 1.58, CI = 1.48 - 1.69, p < 0.0001), additive model(CT vs 
      CC) (OR = 1.34, CI = 1.28-1.39, p < 0.0001), additive model(TT vs CC) (OR = 1.81, 
      CI = 1.69-1.94, p < 0.0001)and allele model (OR = 1.35, CI = 1.31-1.39, 
      p < 0.0001). CONCLUSION: The meta-analysis suggested that rs7903146 was 
      significantly associated with T2DM in Caucasian, East Asian, South Asian and 
      other ethnicities.
FAU - Ding, Weiyue
AU  - Ding W
AD  - College of Computer Science and Technology, Harbin Engineering University, No.145 
      Nantong Street, Nangang District, Harbin, 150001, China.
FAU - Xu, Li
AU  - Xu L
AD  - College of Computer Science and Technology, Harbin Engineering University, No.145 
      Nantong Street, Nangang District, Harbin, 150001, China. xuli@hrbeu.edu.cn.
FAU - Zhang, Lejun
AU  - Zhang L
AD  - School of Information Engineering, Yangzhou University, No.196, Huayang West 
      Road, Yangzhou, 225127, China.
FAU - Han, Zhijie
AU  - Han Z
AD  - School of Life Science and Technology, Harbin Institute of Technology, No.92 
      Xidazhi Street, Nangang District, Harbin, 150001, China.
FAU - Jiang, Qinghua
AU  - Jiang Q
AD  - School of Life Science and Technology, Harbin Institute of Technology, No.92 
      Xidazhi Street, Nangang District, Harbin, 150001, China.
FAU - Wang, Zhe
AU  - Wang Z
AD  - Key Laboratory of Symbolic Computation and Knowledge Engineering of Ministry of 
      Education, Jilin University, No.2699, Qianjin Avenue, Qianweinan District, 
      Changchun, 130012, China.
FAU - Jin, Shuilin
AU  - Jin S
AD  - Department of Mathematics, Harbin Institute of Technology, No.92, Xidazhi Street, 
      Nangang District, Harbin, 150001, China. jinsl@hit.edu.cn.
LA  - eng
GR  - R01 AA021505/AA/NIAAA NIH HHS/United States
GR  - R03 AA020101/AA/NIAAA NIH HHS/United States
PT  - Journal Article
PT  - Meta-Analysis
PT  - Research Support, Non-U.S. Gov't
DEP - 20180307
PL  - England
TA  - BMC Med Genet
JT  - BMC medical genetics
JID - 100968552
RN  - 0 (TCF7L2 protein, human)
RN  - 0 (Transcription Factor 7-Like 2 Protein)
SB  - IM
MH  - Alleles
MH  - Asian People/genetics
MH  - Databases, Factual
MH  - Diabetes Mellitus, Type 2/*diagnosis/*genetics
MH  - Genetic Predisposition to Disease
MH  - Humans
MH  - *Polymorphism, Single Nucleotide
MH  - Publication Bias
MH  - Transcription Factor 7-Like 2 Protein/*genetics
MH  - White People/genetics
PMC - PMC5842570
OTO - NOTNLM
OT  - Meta-analysis
OT  - Polymorphism
OT  - T2DM
OT  - rs7903146
COIS- ETHICS APPROVAL AND CONSENT TO PARTICIPATE: Not applicable. CONSENT FOR 
      PUBLICATION: Not applicable. COMPETING INTERESTS: The authors declared that they 
      had no competing interests. PUBLISHER'S NOTE: Springer Nature remains neutral 
      with regard to jurisdictional claims in published maps and institutional 
      affiliations.
EDAT- 2018/03/09 06:00
MHDA- 2018/12/14 06:00
PMCR- 2018/03/07
CRDT- 2018/03/09 06:00
PHST- 2017/05/01 00:00 [received]
PHST- 2018/02/23 00:00 [accepted]
PHST- 2018/03/09 06:00 [entrez]
PHST- 2018/03/09 06:00 [pubmed]
PHST- 2018/12/14 06:00 [medline]
PHST- 2018/03/07 00:00 [pmc-release]
AID - 10.1186/s12881-018-0553-5 [pii]
AID - 553 [pii]
AID - 10.1186/s12881-018-0553-5 [doi]
PST - epublish
SO  - BMC Med Genet. 2018 Mar 7;19(1):38. doi: 10.1186/s12881-018-0553-5.